Mei Zhong, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2025
Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes
Zhao Q, Hu W, Xia Y, Dai S, Wu X, Chen J, Yuan X, Zhong T, Xi X, Wang Q. Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes. Scientific Reports 2025, 15: 17386. PMID: 40389469, PMCID: PMC12089500, DOI: 10.1038/s41598-025-00179-z.Peer-Reviewed Original ResearchConceptsGene signatureLow-risk score groupIncreased metastasis riskLow-risk patientsSensitive to immunotherapyUnivariate Cox regression analysisReduced immune infiltrationCox regression analysisPersonalized therapeutic strategiesAggressive bone malignancyOsteosarcoma outcomesPersonalized treatment strategiesHigh-risk scoreOverall survivalHigher mortality rateProlonged survivalMetastasis riskMulticenter cohortImmune infiltrationPoor prognosisRisk stratificationC-indexDrug sensitivityClinical managementPrognostic toolNanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy
Xia P, Qu C, Xu X, Tian M, Li Z, Ma J, Hou R, Li H, Rückert F, Zhong T, Zhao L, Yuan Y, Wang J, Li Z. Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy. Journal Of Extracellular Vesicles 2025, 14: e70069. PMID: 40240911, PMCID: PMC12003094, DOI: 10.1002/jev2.70069.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesStimulator of interferon genesOuter membrane vesiclesStimulator of interferon genes agonistsSTING activationCyclic GMP-AMP synthase (cGAS)-STING pathwayNatural stimulationBacterial outer membrane vesiclesInnate immune systemCD47 blockadeAntitumour immunityTumor immunotherapyImmunotherapeutic strategiesMetastatic tumorsTumor selectivityTumor inhibitionImmune memoryCadherin-17TumorCancer cellsCancer treatmentImmune systemInterferon genesCancerClinical application
2024
Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing
Ye Y, Niu C, Mao A, Qin L, Zhan J, Chen W, Liu Z, Xie T, Zhang Q, Li J, Huang L, Meng W, Liu Y, Liao L, Cai J, Liu R, Zhang X, Zeng L, Li Y, Lin B, Li K, Hua X, Huang B, Qin H, Huang Y, Huang Z, Lao J, Qu X, Chen J, Feng X, Liu Q, Lin W, Zhou X, Liang Y, Long X, Qin J, Yan L, Zhu W, Yu L, Fan C, Tang D, Zhong T, Tan J, Ren Z, Xu X. Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing. Advanced Science 2024, 12: 2410992. PMID: 39737841, PMCID: PMC11884621, DOI: 10.1002/advs.202410992.Peer-Reviewed Original ResearchConceptsLong-read sequencingSingle nucleotide variantsGene clusterGlobin gene clusterT-LRSHomologous regionsStructural variantsB-thalassemia patientsTargeted long-read sequencingRare structural variantsB-thalassemiaErythroid transcription factorsHaplotype phasingNucleotide variantsAssociation analysisTranscription factorsGenetic variantsRare mutationsHaplotypesMutation spectrumExpression of fetal hemoglobinMutationsReduce transfusion dependencePatients to dateGenes/lociApplication of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy
Huang D, Xie F, Xiao S, Cai M, Hu D, Ling B, Wang F, Lin X, Song F, Wang Q, Zhong T. Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy. Scientific Reports 2024, 14: 31639. PMID: 39738187, PMCID: PMC11686395, DOI: 10.1038/s41598-024-80639-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsCytochrome P-450 CYP2C9Cytochrome P450 Family 4FemaleGene FrequencyGenotypeGenotyping TechniquesHumansMaleMiddle AgedPharmacogeneticsPharmacogenomic VariantsPolymerase Chain ReactionPolymorphism, Single NucleotidePrecision MedicineVitamin K Epoxide ReductasesWarfarinConceptsVitamin K epoxide reductase complex 1Single-nucleotide polymorphismsAssociated with warfarin dose requirementsSingle-nucleotide polymorphism sitesDirect amplificationGenotyped single-nucleotide polymorphismsPolymorphic SNP sitesCYP2C9*2Polymerase chain reactionWarfarin dose requirementsCYP2C9*3CYP4F2*3Fluorescence melting curve analysisCytochrome P450 2C9Melting curve analysisNested polymerase chain reactionPolymorphic lociSNP sitesAccurate genotypingPharmacogenetic variantsCytochrome P450 4F2Gene sequencesPolymorphism detectionAllele frequenciesP450 2C9Guben Kechuan granule attenuates bronchial asthma by inhibiting NF-κB/STAT3 signaling pathway-mediated apoptosis
Dai C, Liu D, Qin C, Fang J, Cheng G, Xu C, Wang Q, Lu T, Guo Z, Wang J, Zhong T, Guo Q. Guben Kechuan granule attenuates bronchial asthma by inhibiting NF-κB/STAT3 signaling pathway-mediated apoptosis. Journal Of Ethnopharmacology 2024, 340: 119124. PMID: 39694430, DOI: 10.1016/j.jep.2024.119124.Peer-Reviewed Original ResearchConceptsTranscription factor STAT3Bcl-2 expressionAlveolar lavage samplesNF-kBBronchial asthmaBcl-2Caspase-3 expressionProteomic analysisProteomic resultsCaspase-3Rat model of bronchial asthmaRat modelSignaling pathwayAsthma-induced airway inflammationOxidative-stress damageApoptosisModel of bronchial asthmaInflammatory cell infiltrationTranscriptionSTAT3Oxidative-stressCytokines TNF-aOxidative stress damageAirway inflammationIL-5Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure
Qian Y, Hong X, Yu Y, Du C, Li J, Yu J, Xiao W, Chen C, Huang D, Zhong T, Li J, Xiang X, Li Z. Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure. Clinical And Translational Medicine 2024, 14: e70059. PMID: 39406484, PMCID: PMC11479749, DOI: 10.1002/ctm2.70059.Peer-Reviewed Original ResearchWhole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia
Wang X, Zhang Q, Chen X, Huang Y, Zhang W, Liao L, Zhang X, Huang B, Huang Y, Ye Y, Song M, Lao J, Chen J, Feng X, Long X, Liu Z, Zhu W, Yu L, Fan C, Tang D, Zhong T, Fang M, Li C, Niu C, Huang L, Lin B, Hua X, Jin X, Li Z, Xu X. Whole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia. Genomics Proteomics & Bioinformatics 2024, 23: qzae065. PMID: 39331630, PMCID: PMC12373638, DOI: 10.1093/gpbjnl/qzae065.Peer-Reviewed Original ResearchPlatelet traitsAnalysis of whole-genome sequencing dataWhole-genome sequencing dataFunctional annotation dataGenotype-phenotype association studiesRare variantsLack of genetic studiesMean platelet volumeNoncoding genomeWhole genomeSequence dataAssociation studiesMultiple genesGenetic studiesB-thalassemia patientsB-thalassemiaPhenotypic heterogeneityIntegrated analysisTraitsMissenseGenesPotential targetVariantsRV analysisGenome
2023
Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway
Huang D, Zhang W, Chen J, Jiao Z, Wang X, Rao D, Li W, Hu D, Xie F, Wang X, Li Z, Yi X, Wu J, Jiang Y, Wang Q, Zhong T. Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway. Extracellular Vesicles And Circulating Nucleic Acids 2023, 4: 532-547. PMID: 40357132, PMCID: PMC12066417, DOI: 10.20517/evcna.2023.30.Peer-Reviewed Original ResearchVascular endothelial growth factor AHepatocellular carcinomaHealthy donorsSmall extracellular vesiclesNano-flow cytometerEndothelial cell angiogenesisDiagnostic markerLiver cirrhosisPI3K/Akt pathwayCD147 expressionMatrigel plug angiogenesis assayPlasma of HCC patientsPromote angiogenesisHepatocellular carcinoma patientsCell angiogenesisEndothelial growth factor AExtracellular vesiclesGrowth factor AScratch wound healing assayHuman umbilical vein endothelial cellsProcess of HCC developmentHepatocellular carcinoma tissue samplesUmbilical vein endothelial cellsWound healing assayCell proliferation assayGeneration of ventralized human thalamic organoids with thalamic reticular nucleus
Kiral F, Cakir B, Tanaka Y, Kim J, Yang W, Wehbe F, Kang Y, Zhong M, Sancer G, Lee S, Xiang Y, Park I. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell 2023, 30: 677-688.e5. PMID: 37019105, PMCID: PMC10329908, DOI: 10.1016/j.stem.2023.03.007.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsSingle-cell RNA sequencingReceptor tyrosine protein kinaseTyrosine protein kinaseEmbryonic stem cellsDisease-associated genesLineage developmentRNA sequencingHuman brain developmentOrganoid systemsStem cellsHuman brain organoidsNeuronal functionBrain organoidsOrganoidsBrain organoid systemsDistinct nucleiBrain developmentThalamic developmentPTCHD1NucleusKinaseGenesSequencing
2022
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. Nature Communications 2022, 13: 430. PMID: 35058453, PMCID: PMC8776770, DOI: 10.1038/s41467-022-28043-y.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsHuman cortical organoidsTranscription factor PUSingle-cell RNA sequencingMicroglia-like cellsSingle-cell transcriptomicsEmbryonic stem cellsDisease stage IIIRole of microgliaAD-associated genesExpression of genesCortical organoidsNeurodegenerative disordersRNA sequencingMolecular damageIntact complementStem cellsDysfunction of microgliaFunctional microgliaReduced expressionGenesCell clustersExpressionChemokine systemHuman microglia
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