Kirstin Meyer
Assistant Professor in Molecular, Cellular & Developmental BiologyCards
About
Research
Publications
2025
YAP charge patterning mediates signal integration through transcriptional co-condensates
Meyer K, Yserentant K, Cheloor-Kovilakam R, Ruff K, Chung C, Shu X, Huang B, Weiner O. YAP charge patterning mediates signal integration through transcriptional co-condensates. Nature Communications 2025, 16: 7454. PMID: 40796733, PMCID: PMC12343768, DOI: 10.1038/s41467-025-62157-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsGene Expression RegulationHumansIntrinsically Disordered ProteinsMicePhosphoproteinsProtein EngineeringSignal TransductionSingle Molecule ImagingStatic ElectricityTranscription FactorsTranscription, GeneticYAP-Signaling ProteinsConceptsSignaling specificityMolecular basisGene regulatory programsTranscription factor dynamicsTranscriptional regulators YAPAdaptive transcriptional responseTranscriptional condensatesRegulators YAPSequence analysisProtein engineeringTranscriptional responseBiomolecular condensatesRegulatory programsTranscriptionSignal modulationYAPPositively charged blockSynthetic condensatesGenesFactor dynamicsCondensate formationRegulatory behaviorMolecular frameworkSignal integrityCo-condensationWAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation
Wu M, Sadhu R, Meyer K, Tang Z, Marchando P, Woolfson D, Gov N, Weiner O. WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation. Journal Of Cell Biology 2025, 224: e202410098. PMID: 40668190, PMCID: PMC12266138, DOI: 10.1083/jcb.202410098.Peer-Reviewed Original ResearchConceptsNucleation-promoting factorsNegative membrane curvatureLamellipodia formationActin nucleation-promoting factorMembrane curvatureIn vivo biochemical approachesSheet-like lamellipodiaActin-based protrusionsCell morphogenesisMembrane associationCell protrusionsBiochemical approachesUpstream activatorPlasma membraneLamellipodiaProtein arraysMechanistic basesLinear organizationWave complexesComplex patternsABI2WAVE2ActinLinear arrayMorphogenesisEmerging roles of transcriptional condensates as temporal signal integrators
Meyer K, Huang B, Weiner O. Emerging roles of transcriptional condensates as temporal signal integrators. Nature Reviews Genetics 2025, 26: 559-570. PMID: 40240649, PMCID: PMC12277013, DOI: 10.1038/s41576-025-00837-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGene regulatory networksTranscriptional condensatesRegulatory networksControl cell physiologyTemporal signal integrationMethod to probeSignaling networksSignaling specificityCell physiologyGene activationTranscription factorsSignaling DynamicsBiophysical frameworkSignal adaptationTranscriptionGenesSignalDecoding mechanismSignal integrityFrequency of signalsPhysiologyMechanism
2023
Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation
Meyer K, Lammers N, Bugaj L, Garcia H, Weiner O. Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation. Nature Communications 2023, 14: 6929. PMID: 37903793, PMCID: PMC10616176, DOI: 10.1038/s41467-023-42643-2.Peer-Reviewed Original ResearchConceptsCell fateYAP levelsControlling gene activityCell fate analysisPluripotency regulators Oct4Stem cell fateEffector genesTranscriptional regulationGene activationControl pluripotencyYAP activityNative dynamicsCellular differentiationRegulators Oct4Developmental decision-makingControl proliferationMolecular logicCell behaviorYAPFate analysisDynamic decoderOptogenetic controlOct4 expressionCellsFateCell protrusions and contractions generate long-range membrane tension propagation
De Belly H, Yan S, Borja da Rocha H, Ichbiah S, Town J, Zager P, Estrada D, Meyer K, Turlier H, Bustamante C, Weiner O. Cell protrusions and contractions generate long-range membrane tension propagation. Cell 2023, 186: 3049-3061.e15. PMID: 37311454, PMCID: PMC10330871, DOI: 10.1016/j.cell.2023.05.014.Peer-Reviewed Original ResearchConceptsActomyosin contractionPropagation of membrane tensionDual-trap optical tweezersMembrane tensionActin-driven protrusionsActin-based protrusionsCell membraneOptical tweezersActin cortexCell protrusionsCell polarityMembrane flowCell physiologyTension propagationActomyosinTension transmissionCellsMembraneMechanical forcesPropagationProtrusionTweezersActinPolarization
2021
Correction: Quantification of nematic cell polarity in three-dimensional tissues
Scholich A, Syga S, Morales-Navarrete H, Segovia-Miranda F, Nonaka H, Meyer K, de Back W, Brusch L, Kalaidzidis Y, Zerial M, Jülicher F, Friedrich B. Correction: Quantification of nematic cell polarity in three-dimensional tissues. PLOS Computational Biology 2021, 17: e1009349. PMID: 34449770, PMCID: PMC8396746, DOI: 10.1371/journal.pcbi.1009349.Commentaries, Editorials and Letters
2020
Quantification of nematic cell polarity in three-dimensional tissues
Scholich A, Syga S, Morales-Navarrete H, Segovia-Miranda F, Nonaka H, Meyer K, de Back W, Brusch L, Kalaidzidis Y, Zerial M, Jülicher F, Friedrich B. Quantification of nematic cell polarity in three-dimensional tissues. PLOS Computational Biology 2020, 16: e1008412. PMID: 33301446, PMCID: PMC7755288, DOI: 10.1371/journal.pcbi.1008412.Peer-Reviewed Original ResearchBile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration
Meyer K, Morales‐Navarrete H, Seifert S, Wilsch‐Braeuninger M, Dahmen U, Tanaka E, Brusch L, Kalaidzidis Y, Zerial M. Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 2020, 16: msb198985. PMID: 32090478, PMCID: PMC7036714, DOI: 10.15252/msb.20198985.Peer-Reviewed Original ResearchConceptsActin cytoskeletonActive YAPMechanisms of organ size controlF-actin-rich regionsTranscriptional co-activator YAPSurface of hepatocytesOrgan size controlCo-activator YAPApical surface of hepatocytesApical surfaceF-actinAcid fluctuationsHippo signalingTissue homeostasisBile acidsMouse liver regenerationBile acid overloadYAPMechano-sensory systemsCytoskeletonAcid overloadActinBile canalicular networkLevels of bile acidsCanalicular network
2019
Liquid-crystal organization of liver tissue
Morales-Navarrete H, Nonaka H, Scholich A, Segovia-Miranda F, de Back W, Meyer K, Bogorad R, Koteliansky V, Brusch L, Kalaidzidis Y, Jülicher F, Friedrich B, Zerial M. Liquid-crystal organization of liver tissue. ELife 2019, 8: e44860. PMID: 31204997, PMCID: PMC6598764, DOI: 10.7554/elife.44860.Peer-Reviewed Original Research
2018
Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice
Tanaka H, Imasato M, Yamazaki Y, Matsumoto K, Kunimoto K, Delpierre J, Meyer K, Zerial M, Kitamura N, Watanabe M, Tamura A, Tsukita S. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. Journal Of Hepatology 2018, 69: 1308-1316. PMID: 30213590, DOI: 10.1016/j.jhep.2018.08.025.Peer-Reviewed Original ResearchConceptsHepatic tight junctionsCholesterol gallstone diseaseGallstone diseaseAge-related riskParacellular barrierClaudin-3Cholesterol gallstonesParacellular permeability of ionsTight junctionsFormation of cholesterol gallstonesTight junction proteinsHepatobiliary epitheliaIn vivo evidenceParacellular permeabilityCholesterol gallstone formationJunction proteinsGallstonesHepatobiliary systemGallstone formationMiceCholesterolDiseaseCLDN3Ion metabolismMouse liver