Josien C. van Wolfswinkel, PhD, MSc
Associate Professor in Molecular, Cellular & Developmental BiologyDownloadHi-Res Photo
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Molecular, Cellular, and Developmental Biology
260 Whitney Avenue
New Haven, CT 06511
United States
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Associate Professor in Molecular, Cellular & Developmental Biology
Biography
Josien van Wolfswinkel received her M.Sc. in Cell Biology from Utrecht University, Netherlands. For her graduate research she worked in the laboratories of Ronald Plasterk, Albert Heck, and Rene Ketting at Utrecht University and the Hubrecht Institute for Developmental Biology to study the molecular mechanism of RNA interference in the nematode C. elegans. She did her postdoctoral research in the lab of Peter Reddien at the Whitehead Institute for Biomedical Research / MIT, working on the RNA biology of stem cells using the flatworm Schmidtea mediterranea as a model system. She now continues this work in her own lab in the Department of Molecular Cellular and Developmental Biology.
Last Updated on January 09, 2025.
Departments & Organizations
Education & Training
- PhD
- Utrecht University, Hubrecht Institute, Chemistry (2009)
- MSc
- Utrecht University, Molecular Cell Biology (2002)
Research
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Overview
Medical Research Interests
Cell Lineage; Cellular Microenvironment; Developmental Biology; Epigenomics; Genomics; Germ Cells; Inheritance Patterns; Molecular Biology; Pluripotent Stem Cells; Regeneration; Regulatory Sequences, Ribonucleic Acid
ORCID
0000-0003-4221-3218- View Lab Website
Van Wolfswinkel Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Josien C. van Wolfswinkel's published research.
Publications Timeline
A big-picture view of Josien C. van Wolfswinkel's research output by year.
Research Interests
Research topics Josien C. van Wolfswinkel is interested in exploring.
Sudheesh A P, PhD
Geoffrey Thomson, PhD
John Carlson, PhD
Yannick Jacob, PhD
26Publications
1,958Citations
Regeneration
Pluripotent Stem Cells
Germ Cells
Cell Lineage
Genomics
Publications
2026
The Sensory Basis of Planarian Behavior
Ascunce K, Lopez S, Carlson J, van Wolfswinkel J. The Sensory Basis of Planarian Behavior. Journal Of Neuroscience 2026, 46: e1158252025. PMID: 41922186, PMCID: PMC13064805, DOI: 10.1523/jneurosci.1158-25.2025.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAltmetricHost-transposon mutualism supports regeneration in planarians
Lee H, Poulet A, Parambil S, van Wolfswinkel J. Host-transposon mutualism supports regeneration in planarians. Developmental Cell 2026, 61: 1061-1075.e7. PMID: 41916287, PMCID: PMC13047482, DOI: 10.1016/j.devcel.2026.03.001.Peer-Reviewed Original ResearchThis study reveals how the Burro1 transposon supports its planarian host by improving its regenerative abilities, showing that transposons can have mutually beneficial interactions with their host.Drift of positional identity drives reproductive aging in a long-lived regenerative animal
Verdesca A, Poulet A, Bales M, van Wolfswinkel J. Drift of positional identity drives reproductive aging in a long-lived regenerative animal. Current Biology 2026, 36: 1737-1747.e4. PMID: 41875878, PMCID: PMC13020644, DOI: 10.1016/j.cub.2026.02.050.Peer-Reviewed Original ResearchThis study investigates how age-related shifts in positional identity impair fertility in planarians and demonstrates that regeneration or Wnt signaling modulation can restore reproductive function by resetting positional information.
2025
Enhanced RNA quality control maintains long-term regenerative ability in planarians
Zelko M, Li D, Parambil S, Poulet A, Verdesca A, Mazeika K, Dasgupta K, van Wolfswinkel J. Enhanced RNA quality control maintains long-term regenerative ability in planarians. Development 2025, 152: dev204762. PMID: 40955864, PMCID: PMC12579931, DOI: 10.1242/dev.204762.Peer-Reviewed Original ResearchCitationsAltmetricH3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability
Yuan W, Huang Y, LeBlanc C, Poulet A, De Luna Vitorino F, Valsakumar D, Dean R, Garcia B, van Wolfswinkel J, Voigt P, Jacob Y. H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability. Nature Communications 2025, 16: 3547. PMID: 40229276, PMCID: PMC11997104, DOI: 10.1038/s41467-025-58892-2.Peer-Reviewed Original ResearchCitationsAltmetric
2024
PIWI-interacting RNAs: who, what, when, where, why, and how
Haase A, Ketting R, Lai E, van Rij R, Siomi M, Svoboda P, van Wolfswinkel J, Wu P. PIWI-interacting RNAs: who, what, when, where, why, and how. The EMBO Journal 2024, 43: 5335-5339. PMID: 39327528, PMCID: PMC11574264, DOI: 10.1038/s44318-024-00253-8.Peer-Reviewed Original ResearchCitationsAltmetricA comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals
Konstantinidou P, Loubalova Z, Ahrend F, Friman A, Almeida M, Poulet A, Horvat F, Wang Y, Losert W, Lorenzi H, Svoboda P, Miska E, van Wolfswinkel J, Haase A. A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals. Cell Reports 2024, 43: 114777. PMID: 39302833, PMCID: PMC11615739, DOI: 10.1016/j.celrep.2024.114777.Peer-Reviewed Original ResearchCitationsAltmetricGene-edited Mtsoc1 triple mutant Medicago plants do not flower
Poulet A, Zhao M, Peng Y, Tham F, Jaudal M, Zhang L, van Wolfswinkel J, Putterill J. Gene-edited Mtsoc1 triple mutant Medicago plants do not flower. Frontiers In Plant Science 2024, 15: 1357924. PMID: 38469328, PMCID: PMC10926907, DOI: 10.3389/fpls.2024.1357924.Peer-Reviewed Original ResearchCitationsAltmetric
2023
piRNA generation is associated with the pioneer round of translation in stem cells
Parambil S, Li D, Zelko M, Poulet A, van Wolfswinkel J. piRNA generation is associated with the pioneer round of translation in stem cells. Nucleic Acids Research 2023, 52: 2590-2608. PMID: 38142432, PMCID: PMC10954484, DOI: 10.1093/nar/gkad1212.Peer-Reviewed Original ResearchCitationsAltmetricChromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy
Poulet A, Kratkiewicz A, Li D, van Wolfswinkel J. Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy. Science Advances 2023, 9: eadh4887. PMID: 37801496, PMCID: PMC10558129, DOI: 10.1126/sciadv.adh4887.Peer-Reviewed Original ResearchCitationsAltmetric
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Molecular, Cellular, and Developmental Biology
260 Whitney Avenue
New Haven, CT 06511
United States
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Yale Science Building
260 Whitney Avenue
New Haven, CT 06511