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Stephania Libreros, PhD

Assistant Professor
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Contact Info

Vascular Biology and Therapeutics Program

Vascular Biology & Transplantation, PO BOX 208089

New Haven, Connecticut 06520-8089

United States

About

Titles

Assistant Professor

Biography

Dr. Stephania Libreros' lab focuses on uncovering the biochemical, immunological, and molecular mechanisms that restore organ-specific and systemic homeostasis following pathological challenges, and understanding why these mechanisms sometimes fail, leading to chronic inflammation. Her goal is to identify novel pro-resolving mediators and circuits that enhance host protection, promote microbial clearance, and facilitate tissue regeneration in humans.

Dr. Libreros earned her Ph.D. in Immunology, where she studied how pre-existing inflammation drives tumor metastasis and myeloid-induced inflammation. She then completed her postdoctoral fellowship at Harvard University with Professor Charles N. Serhan, working on the structural elucidation of novel molecules and networks that control the resolution of inflammation. Her research explored how these pathways could lead to a new class of therapeutics by harnessing the body's natural ability to resolve inflammation. She has received multiple scientific awards, including the the Eicosanoid Research Foundation Santosh Nigam Outstanding Young Scientist Award, the Early Career Investigator Award from the Society for Leukocyte Biology, and the NIH Pathway to Independence Award (K99/R00).

Dr. Libreros is constant advocator for Diversity, Equity, and Inclusion (DEI) in biomedical Science, where she fosters an inclusive environment and promotes equity as a key driver for innovation and scientific progression.

Appointments

Education & Training

Instructor
Harvard Medical School
Postdoctoral Fellow
Harvard Medical School
PhD
Florida Atlantic University , Integrative Biology/Immunology
BS
Florida Atlantic University , Microbiology - Molecular Cell Biology and Biotechnology (2008)

Research

Overview

We aim to elucidate the biochemical, immunological, and molecular mechanisms that restore organ-specific and systemic homeostasis after pathological challenges, and why these mechanisms occasionally fail, leading to chronic inflammation.

Our research centers in a a key scientific challenge in human pathophysiology: how to harness endogenous resolution mechanisms of inflammation when initial resolution fails. From birth, our bodies are continuously exposed to a myriad of environmental factors, pathogens, and injuries that trigger acute inflammatory responses. These responses are crucial for combating infections, healing wounds, and safeguarding overall health. Ideally, these inflammatory reactions are self-limited, leading to complete resolution of leukocyte infiltration and clearance of cellular debris by macrophages , thereby restoring and maintaining tissue homeostasis. The mechanisms involved in resolution of inflammation are essential for preventing excessive tissue damage, autoimmunity, and progression to chronic inflammation. Without effective resolution mechanisms, our ability to recover from even minor injuries or infections would be severely compromised, leading to serious health issues.

Public Health Interests

Aging; Immunology; Infectious Diseases; Metabolism

Research at a Glance

Yale Co-Authors

Frequent collaborators of Stephania Libreros's published research.

Publications

Featured Publications

2024

2023

Academic Achievements & Community Involvement

  • honor

    Early Investigator Career Award

  • honor

    Santosh Nigam “Outstanding Young Scientist” Award

Get In Touch

Contacts

Academic Office Number
Mailing Address

Vascular Biology and Therapeutics Program

Vascular Biology & Transplantation, PO BOX 208089

New Haven, Connecticut 06520-8089

United States

Administrative Support

Locations

  • Amistad Street Building

    Lab

    10 Amistad Street

    New Haven, CT 06519

  • Amistad Street Building

    Academic Office

    10 Amistad Street, Fl 4, Rm 401A

    New Haven, CT 06519