Publications

2025

• Subgroup of meningiomas involving FOS and FOSB gene fusions

  Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima D, Youngblood M, Hjerthen M, Brooks A, Samuel Lopez N, O’Brien J, Chavez M, Dincer A, Wu H, Omay S, Yasuno K, Bilguvar K, Ercan-Sencicek A, Mishra-Gorur K, McGuone D, Moliterno J, Gunel M, Erson-Omay E. Subgroup of meningiomas involving FOS and FOSB gene fusions. Nature Communications 2025, 16: 10532. PMID: 41298363, PMCID: PMC12657970, DOI: 10.1038/s41467-025-65549-7.

  Peer-Reviewed Original Research

  Altmetric

  MeSH Keywords

• The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice

  Srivastava S, Kato H, von Kroge S, Weise K, Stabach P, Lopez S, O’Brien K, Lester E, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema K, Carpenter T, Sabbagh Y, Tommasini S, Ito N, Oheim R, Braddock D. The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice. Journal Of Bone And Mineral Research 2025, zjaf168. PMID: 41251406, DOI: 10.1093/jbmr/zjaf168.

  Peer-Reviewed Original Research

  Concepts

• Plasmacytoid dendritic cell clusters are associated with poor prognosis in chronic myelomonocytic leukemia.

  Kumar D, Cheng W, Lin L, Raess PW, Xie W, Wong J, Daneshpajouhnejad P, Fathalla LA, Morgan EA, Bagg A, Hasserjian R, Katz SG, Xu ML. Plasmacytoid dendritic cell clusters are associated with poor prognosis in chronic myelomonocytic leukemia. Virchows Arch 2025 PMID: 41247506, DOI: 10.1007/s00428-025-04333-w.

  Peer-Reviewed Original Research

• Sequential class switching generates antigen-specific gut IgA from IgG1 B cells

  Siniscalco E, Meng H, Gabernet G, Pacheco G, Saghaei S, Ramirez S, Hills L, Faraji F, Chen S, Yin X, Dien C, Hoyt L, Liu E, Barrett A, Briggs N, Williams A, Shukla V, Crotty S, Wesemann D, Kleinstein S, Craft J, Eisenbarth S. Sequential class switching generates antigen-specific gut IgA from IgG1 B cells. Immunity 2025 PMID: 41253159, DOI: 10.1016/j.immuni.2025.10.022.

  Peer-Reviewed Original Research

  This study investigates how gut-specific IgA antibodies are generated from IgG1 B cells through sequential class switching, highlighting a crucial mechanism for designing effective mucosal vaccines.

  Full Summary

• Mixed Molecular Subtypes Coexist in Estrogen Receptor Heterogeneous Primary Breast Cancers

  Foldi J, Xiong K, Liu M, Robbins C, Chen F, Zhan H, Burela S, Dai J, Karn P, Dugo M, Bianchini G, Lee A, Oesterreich S, Rimm D, Pusztai L. Mixed Molecular Subtypes Coexist in Estrogen Receptor Heterogeneous Primary Breast Cancers. JCO Precision Oncology 2025, 9: e2500529. PMID: 41237360, DOI: 10.1200/po-25-00529.

  Peer-Reviewed Original Research

  Altmetric

  MeSH Keywords and Concepts

• 907 Midkine suppresses interferon-driven antigen presentation and dendritic-cell activation in neuroendocrine tumors

  Wang J, Perry C, Frey A, Fei Y, Costa P, Ghadermarzi S, Levine D, Ishizuka J. 907 Midkine suppresses interferon-driven antigen presentation and dendritic-cell activation in neuroendocrine tumors. 2025, a1027-a1027. DOI: 10.1136/jitc-2025-sitc2025.0907.

  Peer-Reviewed Original Research

  Concepts

• Development of ex vivo patient-derived models to uncover the role of the tumor immune microenvironment in renal cell carcinoma 4463

  Gupta R, Kashima S, Moritz V, Sadak K, Ng M, Adeniran A, Humphrey P, Bosenberg M, Hurwitz M, Kenney P, Braun D. Development of ex vivo patient-derived models to uncover the role of the tumor immune microenvironment in renal cell carcinoma 4463. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2144.

  Peer-Reviewed Original Research

  Concepts

• Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547

  Doherty E, Par-Young J, Osmani L, Filler R, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Unutmaz D, Wilen C, Geall A, Kang I, Bucala R. Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2218.

  Peer-Reviewed Original Research

• Increased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225

  Par-Young J, Osmani L, Doherty E, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Geall A, Kang I, Bucala R. Increased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2654.

  Peer-Reviewed Original Research

• Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma

  Bi K, Kashima S, Camp S, Meli K, Saad E, Titchen B, Labaki C, Bakouny Z, Pimenta E, Park J, Shannon E, Fu J, Xirenayi S, Horst J, Lum L, Ishizuka J, Choueiri T, Braun D, Van Allen E. Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma. Immunity 2025, 58: 2814-2829.e9. PMID: 41175876, PMCID: PMC12616721, DOI: 10.1016/j.immuni.2025.10.013.

  Peer-Reviewed Original Research

  Citations

  Altmetric

  MeSH Keywords and Concepts

• Nivolumab and Cabozantinib Combination Therapy Demonstrates Sustained Efficacy in Metastatic Renal Cell Carcinoma

  Yochum Z, Braun D. Nivolumab and Cabozantinib Combination Therapy Demonstrates Sustained Efficacy in Metastatic Renal Cell Carcinoma. Annals Of Oncology 2025 PMID: 41176229, DOI: 10.1016/j.annonc.2025.10.1238.

  Peer-Reviewed Original Research

  Concepts

• Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice.

  Mafra K, de Oliveira M, Nakagaki B, Porto Pedrosa M, Lanser T, da Silva P, Antunes M, da Silva Júnior W, Mattos M, Lopes M, da Rocha Fernandes G, Cunha T, Pinto de Paula C, David B, Rastogi T, Yang Z, Babar M, Konnikava L, Caetano A, Vale A, Kubes P, Libreros S, Rezende R, Menezes G. Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice. The Journal Of Immunology 2025 PMID: 41138221, DOI: 10.1093/jimmun/vkaf264.

  Peer-Reviewed Original Research

  Altmetric

  Concepts

• Invasive breast carcinoma in a patient with PHTS: a case report

  Zhan H, Fischbach N, Lynch M, Liang Y, Krishnamurti U, Cohen P. Invasive breast carcinoma in a patient with PHTS: a case report. Diagnostic Pathology 2025, 20: 120. PMID: 41107919, PMCID: PMC12532417, DOI: 10.1186/s13000-025-01715-1.

  Peer-Reviewed Original Research

  MeSH Keywords and Concepts

• Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

  Aung T, Monkman J, Warrell J, Vathiotis I, Bates K, Gavrielatou N, Trontzas I, Tan C, Fernandez A, Moutafi M, O’ Byrne K, Schalper K, Syrigos K, Herbst R, Kulasinghe A, Rimm D. Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer. Nature Genetics 2025, 57: 2482-2493. PMID: 41073787, PMCID: PMC12513832, DOI: 10.1038/s41588-025-02351-7.

  Peer-Reviewed Original Research

  Citations

  Altmetric

  MeSH Keywords and Concepts

• Pathomic Immune Biomarkers Define Recurrence Risk in Early-Stage Melanoma.

  Aung TN, Singh A, Espinoza G, Zhang C, Jiang T, Kenchappa D, Bracero Y, Rakhade S, Sultana S, Shukla S, Nghiem E, Abbruzzese M, Kuang C, Geskin L, Entenberg D, Gartrell R, Ferringer T, Leung L, Moon JY, Horst B, Nastiuk K, Rimm D, Chang R, Saenger Y. Pathomic Immune Biomarkers Define Recurrence Risk in Early-Stage Melanoma. Oncologist 2025 PMID: 41052286, DOI: 10.1093/oncolo/oyaf327.

  Peer-Reviewed Original Research

• Codanin-1, defective in congenital dyserythropoietic anemia I (CDA-I), regulates erythroid differentiation

  Bosques L, Modepalli S, Nagarajan A, Tang C, Martínez-Morilla S, Rahman N, Mehta S, Krause D, Tamary H, Gallagher P, Hattangadi S, Kupfer G. Codanin-1, defective in congenital dyserythropoietic anemia I (CDA-I), regulates erythroid differentiation. Annals Of Hematology 2025, 1-15. PMID: 41028447, DOI: 10.1007/s00277-025-06540-6.

  Peer-Reviewed Original Research

  Concepts

• Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma

  Frey A, Clulo K, Fei Y, Dumit T, Scallo F, Williams J, Chang E, Perry C, Wirth L, Jacobs D, Braun D, Bosenberg M, Tran T, Clune J, Kluger H, Olino K, Ishizuka J. Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma. Cell Reports 2025, 44: 116359. PMID: 41042672, DOI: 10.1016/j.celrep.2025.116359.

  Peer-Reviewed Original Research

  Altmetric

  Concepts

• 24TGF-Beta alters CD8+ T cell phenotype and drives resistance to immune checkpoint inhibitors (ICI) in renal cell carcinoma (RCC)

  Rout R, Kashima S, Hugaboom M, Ye Z, Schindler N, Dighe A, Sun M, Lee G, Xu W, Signoretti S, McGregor B, McKay R, Choueri T, Braun D. 24TGF-Beta alters CD8+ T cell phenotype and drives resistance to immune checkpoint inhibitors (ICI) in renal cell carcinoma (RCC). The Oncologist 2025, 30: oyaf276.025. PMCID: PMC12509635, DOI: 10.1093/oncolo/oyaf276.025.

  Peer-Reviewed Original Research

  Concepts

• 31Lymphocyte heat shock signature predicts response to immune checkpoint blockade in renal cell carcinoma

  Burns E, Kashima S, Rout R, Hugaboom M, Ye Z, Schindler N, Dighe A, Sun M, Lee G, Xu W, Atkins M, Signoretti S, McGregor B, McKay R, Choueri T, Braun D. 31Lymphocyte heat shock signature predicts response to immune checkpoint blockade in renal cell carcinoma. The Oncologist 2025, 30: oyaf276.032. PMCID: PMC12509613, DOI: 10.1093/oncolo/oyaf276.032.

  Peer-Reviewed Original Research

  Concepts

• 41Single-cell dissection of immunosuppressive myeloid subclusters driving resistance to immune checkpoint therapy in renal cell carcinoma (RCC)

  Kashima S, Rout R, Hugaboom M, Ye Z, Schindler N, Dighe A, Sun M, Lee G, Xu W, Signoretti S, McGregor B, McKay R, Choueri T, Braun D. 41Single-cell dissection of immunosuppressive myeloid subclusters driving resistance to immune checkpoint therapy in renal cell carcinoma (RCC). The Oncologist 2025, 30: oyaf276.042. PMCID: PMC12509592, DOI: 10.1093/oncolo/oyaf276.042.

  Peer-Reviewed Original Research

  Concepts

• Interobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study

  Korie U, Ai D, Podany P, Zhang H, Zhan H, Kahila M, Colon-Cartagena L, Wei S, Sun H, Du J, Krishnamurti U, Liang Y. Interobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study. American Journal Of Clinical Pathology 2025, 164: 704-711. PMID: 40994034, DOI: 10.1093/ajcp/aqaf088.

  Peer-Reviewed Original Research

  MeSH Keywords and Concepts

• Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration

  Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.

  Peer-Reviewed Original Research

  Citations

  Altmetric

  MeSH Keywords and Concepts

• Weekly dosing schedule of brentuximab vedotin is well tolerated in mycosis fungoides/Sézary syndrome

  Lee M, Schiffer M, Isufi I, Huntington S, Xu M, Sethi T, Kothari S, Girardi M, Foss F. Weekly dosing schedule of brentuximab vedotin is well tolerated in mycosis fungoides/Sézary syndrome. British Journal Of Haematology 2025 PMID: 40968584, DOI: 10.1111/bjh.70147.

  Peer-Reviewed Original Research

  Altmetric

  Concepts

• Margin clearance and post‐procedure ablation decrease recurrence risk in endoscopic mucosal resections for Barrett's‐related neoplasia

  Bell P, Kaul V, Bittner K, Chen I, Huber A, Sagan O, Chen W, Nalbantoglu I, Gonzalez R. Margin clearance and post‐procedure ablation decrease recurrence risk in endoscopic mucosal resections for Barrett's‐related neoplasia. Histopathology 2025 PMID: 40964766, DOI: 10.1111/his.15554.

  Peer-Reviewed Original Research

  Citations

  Altmetric

  Concepts

• Dermatologist prescribing patterns for androgenetic alopecia therapies among Medicare beneficiaries

  Sun Q, Damsky W, Cohen J. Dermatologist prescribing patterns for androgenetic alopecia therapies among Medicare beneficiaries. Archives Of Dermatological Research 2025, 317: 872. DOI: 10.1007/s00403-025-04374-w.

  Peer-Reviewed Original Research