2010
Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection
Mason W, Liu C, Aldrich C, Litwin S, Yeh M. Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection. Journal Of Virology 2010, 84: 8308-8315. PMID: 20519397, PMCID: PMC2916518, DOI: 10.1128/jvi.00833-10.Peer-Reviewed Original ResearchMeSH KeywordsCell Transformation, ViralDNA, ViralHepatitis B virusHepatitis B, ChronicHepatocytesHumansMaleSelection, GeneticVirus IntegrationConceptsChronic hepatitis B virus infectionHepatitis B virus infectionB virus infectionExtensive clonal expansionClonal expansionHBV DNAInfected hepatocytesNoncirrhotic liverVirus infectionHepatocellular carcinomaImmune killingHuman HBV carriersNormal-appearing hepatocytesHuman hepatocytesWoodchuck hepatitis virusIntegrated HBV DNAHBV carriersSurgical resectionChronic infectionHepatitis virusNoncancerous liverInfectionLiverTissue sectionsHepatocytes
2000
Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections
Guo J, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker T, Barrasa M, Mason W, Seeger C. Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections. Journal Of Virology 2000, 74: 1495-1505. PMID: 10627561, PMCID: PMC111485, DOI: 10.1128/jvi.74.3.1495-1505.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDNA, ViralHepatitis BHepatitis B Virus, WoodchuckHepatitis B, ChronicInterferon-gammaLiverLiver RegenerationMarmotaMolecular Sequence DataReverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor-alphaViremiaConceptsRegeneration of hepatocytesHepadnavirus infectionTransient infectionHepatitis B virus infectionTumor necrosis factor alphaTransient hepadnavirus infectionsB virus infectionT cell accumulationNecrosis factor alphaCytokine expressionInfected hepatocytesFactor alphaT cellsVirus infectionInterferon gammaInfected liverHistologic analysisLiver tissueInfectionRecovery periodSignificant increaseHepatocytesInitial influxUnknown mechanismApoptosis