2016
Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits
Liu Y, Wang S, Hwu H, Fann C, Yang U, Yang W, Hsu P, Chang C, Wen C, Tsai-Wu J, Hwang T, Hsieh M, Liu C, Chien Y, Fang C, Faraone S, Tsuang M, Chen W, Liu C. Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits. PLOS ONE 2016, 11: e0150435. PMID: 26986737, PMCID: PMC4795637, DOI: 10.1371/journal.pone.0150435.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with schizophreniaIntron 8Genomic regionsIntron 1Genetic variantsLarger patient samplesD-amino-acid oxidase geneNovel single‐nucleotide polymorphismsHaplotype association analysisSingle-locus analysisExecutive functionD-amino acid oxidaseFunctional genetic variantsSustained attentionNeurocognitive functionSchizophreniaEpstein-Barr virus-transformed lymphocytesMRNA expressionHaplotype blocksSingle-locusHaplotype distributionVirus-transformed lymphocytesHaplotype frequenciesAssociation analysis
2015
Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis
Liu C, Hua M, Hwang T, Chiu C, Liu C, Hsieh M, Chien Y, Lin Y, Hwu H. Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis. Schizophrenia Research 2015, 164: 40-46. PMID: 25802138, DOI: 10.1016/j.schres.2015.03.006.Peer-Reviewed Original ResearchConceptsUltra-high riskPre-psychotic stateNeurocognitive functionWechsler Adult Intelligence Scale-Third EditionWechsler Memory Scale-Third EditionRisk of transition to psychosisWisconsin Card Sorting TestCard Sorting TestDomains of neurocognitionNeurocognitive function of patientsTransition to psychosisContinuous Performance TestVerbal fluency testTrail Making TestLevels of clinical severityFollow-up assessmentStability of changesSorting TestNeuropsychological batteryOnset of illnessNeurocognitive profileEpisode psychosisFluency testNeurocognitive deficitsFunction of subjects