Association Between Parity and Restless Legs Syndrome in a Population of US Women
November 27, 2021- 00:02This is like syndrome,
- 00:03often referred to as RLS,
- 00:05is a neurological sensory motor
- 00:06disorder that is characterized by an
- 00:08uncomfortable urge to move the legs.
- 00:10Women are twice as likely to
- 00:11be affected compared to men.
- 00:13Did Colonel Literature has suggested
- 00:14that pregnancy may explain
- 00:15some of the gender difference.
- 00:17So far multiple observational studies
- 00:19have found positive association
- 00:21between parity and wireless,
- 00:22but presently there is limited
- 00:23understanding about those response.
- 00:24Interaction to the best of our knowledge,
- 00:28there has only been one population based
- 00:30cross sectional study that has analyzed.
- 00:31It's just association by limitation
- 00:33of that study was their method,
- 00:35which failed to all other
- 00:37conditions that may mimic RLS.
- 00:38Since that study,
- 00:39the Cambridge Hopkins are less
- 00:41questionnaire was created for use
- 00:42in RLS research methodology and
- 00:44is designed to exclude mimics.
- 00:46The primary objective of our study
- 00:47is to determine whether there
- 00:49is a dose response relationship
- 00:51between greater parity and RLS.
- 00:52Furthermore,
- 00:53our secondary objectives are to
- 00:54assess the association between
- 00:56biological sex and rolls without the
- 00:58effect of parity and to identify any
- 01:00potential independent predictors.
- 01:01Associated with RLS in our model,
- 01:04our study is a cross sectional
- 01:06design on data collected in a prior
- 01:08study that looked at hypothyroidism.
- 01:09Prevalence in the large population
- 01:11of individuals with or without this
- 01:14data set was appropriate for current
- 01:16study because it also contains helpful
- 01:18information on past pregnancies.
- 01:20The female participants were asked
- 01:21to report their total number of
- 01:23pregnancy events in the accompanying
- 01:25gestational weeks and outcome,
- 01:26whether that is live birth still,
- 01:27birth, miscarriage, or planned abortion.
- 01:30To define priority,
- 01:31we use American College of Obstetricians.
- 01:33Gynecologist definition,
- 01:34which is any like pregnancy or
- 01:36still birth greater than or equal
- 01:38to 20 weeks to ascertain RL status,
- 01:40we asked participants who completed
- 01:42Cambridge Hopkins or less questionnaire
- 01:44and for analysis we share for women
- 01:46based on the total number of Paris
- 01:48events and no data that were excluded
- 01:50from the analysis will get a table one.
- 01:52We found that having no pair servant
- 01:54and having one Paris with it or
- 01:56more common in the negative women
- 01:57whereas having two pairs events in
- 01:59having through more Paris events were
- 02:01more common in the positive woman.
- 02:03In our most like their model,
- 02:05we found that women with one person
- 02:07had 1.44 times the odds of having our
- 02:09list compared to normal Paris woman.
- 02:11But this difference was not significant.
- 02:13However,
- 02:13women with two pairs event at 3.3 times,
- 02:16often women with three or more
- 02:18Paris events had 3.31 times odds
- 02:20of having our allies,
- 02:21and these differences were significant.
- 02:24When assessing her dose
- 02:25response relationship,
- 02:26we also noted a positive trend
- 02:28between the purity groups and
- 02:29all the findings I just mentioned
- 02:31are reflected in figure one,
- 02:33former vault type variant model.
- 02:35We identify Agent depression
- 02:37as independent predictors.
- 02:38We found that there is a 10% increase
- 02:40odds of having RLS with each year
- 02:42increasing age and women who reported
- 02:44depression had 2.5 times odds of
- 02:47having RLS compared to women who did
- 02:49not report depression to assess the
- 02:51association between biological sex
- 02:52and or less without the effect of.
- 02:55Apparently we applied a separate regression
- 02:57analysis that look that compare mental
- 02:59Nola Paris woman looking at table three.
- 03:02We found there is no association between
- 03:04sex and or less after adjusting for age
- 03:06in conjunction with their main finding,
- 03:09we can infer that it is not
- 03:10necessarily the biological sex,
- 03:11but rather the effect of
- 03:13the childbearing potential.
- 03:14There may be counted for the
- 03:16gender difference that is noted
- 03:17in the current literature.
- 03:19Some notable strength over study
- 03:20include the use of the Cambridge
- 03:22Hopkins on RLS Questionnaire,
- 03:23which is a validated questionnaire
- 03:25with high sensitivity.
- 03:26And specificity,
- 03:27and that is designed to exclude RLS mimics
- 03:30to define our main variable of interest,
- 03:32we utilize a professional body.
- 03:33The ACOG to provide a standard
- 03:36consensus on the definition of parity.
- 03:39Lastly,
- 03:39this study attempts to provide better
- 03:41understanding about possible dose response,
- 03:43interaction between parity and RLS,
- 03:45which is an area of limited research and
- 03:47understanding the current literature.
- 03:49There are also some several notable
- 03:51limitations with their study.
- 03:52First is with a cross sectional
- 03:53analysis on data from a prior study.
- 03:55They use a case control design
- 03:58which may introduce selection bias.
- 04:00Second,
- 04:00a large proportion of the symbols
- 04:02of Caucasian race.
- 04:02Therefore,
- 04:03this may not be generalizable
- 04:05to other ethnicities.
- 04:06Third,
- 04:06the participants were asked to provide
- 04:08retrospective data on their past pregnancies,
- 04:11which may have introduced recall bias
- 04:12as these events were several decades
- 04:14in the past for some of our participants,
- 04:164th depression was self reported and
- 04:18this was not confirmed with objectives.
- 04:20Sources such as medical records.
- 04:22So in conclusion,
- 04:23in line with Bergeron on their 2004 study,
- 04:25we also observed a dose response relationship
- 04:28between greater purity and analyst.
- 04:30We identify Asian depression as
- 04:32independent predictors in our group.
- 04:34However,
- 04:34the data around this is conflicting.
- 04:36Lastly, we found no association
- 04:38between biological sex and RLS,
- 04:39suggesting that parity in pregnancy or likely
- 04:42factors in explaining the gender difference,
- 04:44and so far,
- 04:45both iron deficiency anemia.
- 04:46Hormonal changes during pregnancy have
- 04:48been implicated as likely explanations.
- 04:50Are less pathophysiology,
- 04:51but more research is still needed to
- 04:54better understand these interactions
- 04:56in order to provide more optimal
- 04:58therapy for pregnant women with RLS.
- 05:00Given that most pharmacologic used
- 05:02to treat RLS or unsafe in pregnancy.
- 05:05Thank you for listening.