Mancy Tong, PhD
Assistant Professor of Obstetrics, Gynecology & Reproductive SciencesDownloadHi-Res Photo
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Assistant Professor of Obstetrics, Gynecology & Reproductive Sciences
Biography
Dr. Mancy Tong obtained her Ph.D. in Obstetrics and Gynecology from The University of Auckland, New Zealand in 2017. She trained as a postdoctoral associate in reproductive immunology at Yale School of Medicine and in 2020, she was awarded an NIH K99/R00 Pathways to Independence Award from NICHD and joined the faculty in the Department of Obstetrics, Gynecology and Reproductive Sciences at the Yale School of Medicine.
Dr. Tong has published in leading journals in Reproductive Sciences and her current R01-funded research program focuses on determining the impact of viral infection and inflammation on endometrial differentiation and their downstream effects on placental development and pregnancy outcomes. Dr. Tong is a strong advocate for mentorship and she serves as Chair for the Career Development Committee in the Society for Reproductive Investigation. She is also an active member of the International Federation of Placenta Associations, and serves on the editorial board for Human Reproduction Update and Trophoblast Research.
Last Updated on September 22, 2025.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Associate research scientist
- Yale School of Medicine (2022)
- Postdoctoral Associate
- Yale University (2020)
- PhD
- The University of Auckland, Obstetrics and Gynaecology (2017)
- BS (Hon)
- The University of Auckland, Biomedical Sciences (2012)
Research
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Overview
Medical Research Interests
Abortion, Habitual; Abortion, Spontaneous; Decidua; Endometrium; Extracellular Vesicles; Fetal Growth Retardation; Hypertension, Pregnancy-Induced; Inflammation; Neutrophils; Placenta; Pregnancy; Pregnancy Complications; Toll-Like Receptors
ORCID
0000-0002-7378-8033
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mancy Tong's published research.
Publications Timeline
A big-picture view of Mancy Tong's research output by year.
Research Interests
Research topics Mancy Tong is interested in exploring.
Vikki M Abrahams, PhD
Seth Guller, PhD
Alyssa Ann Grimshaw, MBA, MLIS, MPH
Hanah Georges, PhD
Shannon Whirledge, PhD, MSc
17Publications
595Citations
Pregnancy
Placenta
Endometrium
Extracellular Vesicles
Inflammation
Pregnancy Complications
Publications
2024
TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
Georges H, Cassin C, Tong M, Abrahams V. TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. Immunology 2024, 172: 577-587. PMID: 38631842, PMCID: PMC11223956, DOI: 10.1111/imm.13794.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα
Tong M, Scott J, Whirledge S, Abrahams V. Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα. Journal Of Reproductive Immunology 2023, 159: 103988. PMID: 37451159, PMCID: PMC10530124, DOI: 10.1016/j.jri.2023.103988.Peer-Reviewed Original ResearchCitationsAltmetricEndometrial responses to bacterial and viral infection: a scoping review.
Lindsay C, Potter J, Grimshaw A, Abrahams V, Tong M. Endometrial responses to bacterial and viral infection: a scoping review. Human Reproduction Update 2023, 29: 675-693. PMID: 37290428, PMCID: PMC10477945, DOI: 10.1093/humupd/dmad013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2020
Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS
Potter JA, Tong M, Aldo P, Kwon JY, Pitruzzello M, Mor G, Abrahams VM. Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS. Journal Of Reproductive Immunology 2020, 140: 103126. PMID: 32289593, PMCID: PMC7299810, DOI: 10.1016/j.jri.2020.103126.Peer-Reviewed Original ResearchCitationsImmunology of the Placenta
Tong M, Abrahams VM. Immunology of the Placenta. Obstetrics And Gynecology Clinics Of North America 2020, 47: 49-63. PMID: 32008671, DOI: 10.1016/j.ogc.2019.10.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2019
LPS-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps
Tong M, Potter JA, Mor G, Abrahams VM. LPS-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps. The Journal Of Immunology 2019, 203: 500-510. PMID: 31167775, PMCID: PMC6616008, DOI: 10.4049/jimmunol.1900262.Peer-Reviewed Original ResearchCitationsAltmetric
2018
Immunological effects of placental extracellular vesicles
Tong M, Abrahams VM, Chamley LW. Immunological effects of placental extracellular vesicles. Immunology And Cell Biology 2018, 96: 714-722. PMID: 29604098, DOI: 10.1111/imcb.12049.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2017
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchCitationsAltmetricLow molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies
Quao ZC, Tong M, Bryce E, Guller S, Chamley LW, Abrahams VM. Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American Journal Of Reproductive Immunology 2017, 79 PMID: 29135051, PMCID: PMC5728699, DOI: 10.1111/aji.12785.Peer-Reviewed Original ResearchCitationsMeSH KeywordsAntibodies, AntiphospholipidAntiphospholipid SyndromeAspirinbeta 2-Glycoprotein ICells, CulturedChemokinesDisease ProgressionDrug Therapy, CombinationEndometriumEndothelial CellsFemaleHeparin, Low-Molecular-WeightHumansMembrane ProteinsNeovascularization, PhysiologicPregnancyPregnancy ComplicationsTrophoblastsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. The Journal Of Immunology 2017, 199: 2885-2895. PMID: 28916522, PMCID: PMC5659726, DOI: 10.4049/jimmunol.1700870.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsc-Mer Tyrosine KinaseCells, CulturedChorioamnionitisExtraembryonic MembranesFemaleGammaherpesvirinaeHerpesviridae InfectionsHerpesvirus 2, HumanHumansImmunizationInflammasomesIntercellular Signaling Peptides and ProteinsInterleukin-1betaLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutPregnancyPremature BirthProto-Oncogene ProteinsReceptor Protein-Tyrosine Kinases
Academic Achievements & Community Involvement
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Honors
honor Paul Titus Fellowship
09/01/2025Yale School of Medicine Awardhonor Longo/Power New Investigator Award in Maternal-fetal and Perinatal Biology
02/12/2025International AwardLoma Linda Universityhonor Rudolph J. Anderson Endowed Postdoctoral Fellowship
10/01/2024Yale School of Medicine AwardOffice of Physician and Physician Scientist Developmenthonor Pfizer President’s Presenter’s Award
03/11/2020International AwardSociety of Reproductive InvestigationDetailsCanadahonor Elsevier Trophoblast Research New Investigator Award
09/23/2018International AwardInternational Federation of Placenta AssociationDetailsJapan
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