Tamrin Chowdhury
she/her/hers
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About
Titles
Postdoctoral Associate
Appointments
Education & Training
- PhD
- Seoul National University, Translational Medicine
- MSc
- Seoul National University, Neurosurgery
- MBBS
- University of Dhaka, Sher e Bangla Medical College
Research
Overview
Medical Subject Headings (MeSH)
Genomics; Glioblastoma
ORCID
0000-0002-6747-6316
Research at a Glance
Publications Timeline
A big-picture view of Tamrin Chowdhury's research output by year.
Research Interests
Research topics Tamrin Chowdhury is interested in exploring.
18Publications
424Citations
Glioblastoma
Genomics
Publications
Featured Publications
The telomere maintenance mechanism spectrum and its dynamics in gliomas
Kim S, Chowdhury T, Yu H, Kahng J, Lee C, Choi S, Kim K, Kang H, Lee J, Lee S, Won J, Kim K, Kim M, Lee J, Kim J, Kim Y, Kim T, Choi S, Phi J, Shin Y, Ku J, Lee S, Yun H, Lee H, Kim D, Kim K, Hur J, Park S, Kim S, Park C. The telomere maintenance mechanism spectrum and its dynamics in gliomas. Genome Medicine 2022, 14: 88. PMID: 35953846, PMCID: PMC9367055, DOI: 10.1186/s13073-022-01095-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTERT promoter mutationsTelomere maintenance mechanismTelomerase activityGlioma samplesTERT expressionPromoter mutationsCancer management strategiesSlow growth potentialCancer cell immortalityC-circle assayGlioma patientsSeparate cohortNegative groupGlioma progressionNanoString analysisTumor tissueTelomerase enzyme activityGliomasTumor cellsConclusionsThis studyALTATRX mutationsTelomerase activationATRX lossConsiderable proportionSubcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma
Kim S, Park S, Chowdhury T, Hong J, Ahn J, Jeong T, Yu H, Shin Y, Ku J, Park J, Hur J, Lee H, Kim K, Park C. Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma. Cellular And Molecular Life Sciences 2022, 79: 181. PMID: 35278143, PMCID: PMC8918182, DOI: 10.1007/s00018-022-04188-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMesenchymal transitionCell linesAvailable single-cell RNA-seq dataMesenchymal transition (EMT) processCancer cell linesSame tissue samplesTherapeutic implicationsTumor samplesRecurrent samplesDriver mutationsGlioblastomaTissue samplesDistinct cancer cell linesGBM samplesIntratumoral heterogeneityTranscriptomic characteristicsA glioneuronal tumor with CLIP2-MET fusion
Chowdhury T, Lee Y, Kim S, Yu H, Ji S, Bae J, Won J, Shin J, Weinberger D, Choi S, Park C, Kim J, Park S. A glioneuronal tumor with CLIP2-MET fusion. Npj Genomic Medicine 2020, 5: 24. PMID: 32550005, PMCID: PMC7270112, DOI: 10.1038/s41525-020-0131-6.Peer-Reviewed Original ResearchCitationsAltmetricGenomic analysis of synchronous intracranial meningiomas with different histological grades
Chowdhury T, Yoo Y, Seo Y, Dho Y, Kim S, Choi A, Choi M, Park S, Park C, Lee S, Lee J. Genomic analysis of synchronous intracranial meningiomas with different histological grades. Journal Of Neuro-Oncology 2018, 138: 41-48. PMID: 29423538, DOI: 10.1007/s11060-018-2772-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDifferent histological gradesWhole-exome sequencingHistological gradeDistinct gene expression profilesRNA-seq analysisRNA sequencing analysisSynchronous meningiomaGene expression profilesYear old female patientGenomic analysisCommon primary tumorExpression profilesGenomic eventsGenomic evaluationMechanisms of progressionSubsequent mutationsHigh gradeCentral nervous system
2024
Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
Lee Y, Chowdhury T, Kim S, Yu H, Kim K, Kang H, Kim M, Kim J, Kim Y, Ji S, Hwang K, Han J, Hwang J, Yoo S, Lee K, Choe G, Won J, Park S, Lee Y, Shin J, Park C, Kim C, Kim J. Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression. Experimental & Molecular Medicine 2024, 56: 975-986. PMID: 38609519, PMCID: PMC11059271, DOI: 10.1038/s12276-024-01204-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsWhole-exome sequencingNeuronal development pathwaysDrivers of tumorigenesisGlial cell differentiationMethylation sequencingGenomic eventsPI3K-Akt activationDownstream eventsGene markersMultiomics approachCell differentiationRadial glial cellsHypomethylationOverexpressionSequenceTumorigenesisFGFR3Cell signaturesGlial cellsPotential roleCellsTumor cellsCentral nervous systemMultiomicsOntogeny
2023
TMIC-20. A SPATIALLY RESOLVED HUMAN GLIOBLASTOMA ATLAS REVEALS DISTINCT CELLULAR AND MOLECULAR PATTERNS OF ANATOMICAL NICHES
Shah N, Park H, Sonpatki P, Han K, Yu H, Kim S, Chowdhury T, Byun Y, Kang H, Lee J, Lee S, Won J, Kim T, Choi S, Shin Y, Ku J, Lee S, Yun H, Park S, Park C, Park W. TMIC-20. A SPATIALLY RESOLVED HUMAN GLIOBLASTOMA ATLAS REVEALS DISTINCT CELLULAR AND MOLECULAR PATTERNS OF ANATOMICAL NICHES. Neuro-Oncology 2023, 25: v282-v282. PMCID: PMC10639919, DOI: 10.1093/neuonc/noad179.1086.Peer-Reviewed Original ResearchConceptsCellular componentsBulk RNA-seq dataAnatomical nichesSingle-cell atlasSingle-cell RNARNA-seq dataMulti-omics profilingDifferent cellular componentsInteraction networksSpatial transcriptomeCellular heterogeneitySpatial interaction networkDistinct cellularMolecular patternsCellular architectureNicheUnrecognized subtypesSpatial organizationAbstract GlioblastomaValuable resourceGlioma samplesStromal cellsEffective combinatorial therapiesComprehensive insightGlioblastomaPatient-derived glioblastoma cell lines with conserved genome profiles of the original tissue
Kim S, Cho Y, Shin Y, Yu H, Chowdhury T, Kim S, Yi K, Choi C, Cha S, Park C, Ku J. Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue. Scientific Data 2023, 10: 448. PMID: 37438387, PMCID: PMC10338444, DOI: 10.1038/s41597-023-02365-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCell linesPatient-derived glioblastoma cell linesPatient-derived cell linesWhole exome sequencing datasetsExome sequencing datasetsGBM cell linesGlioblastoma cell linesSequence dataGenomic featuresLethal intracranial tumorSequencing technologiesSequencing datasetsMolecular markersWES datasetsGenome profilesMutational signaturesDruggable targetsNumber alterationsBiological credibilityGenomic profilesBiological platformMolecular characteristicsOriginal tissueTumor tissueGlioblastoma
2022
Pyridine-NBD: A homocysteine-selective fluorescent probe for glioblastoma (GBM) diagnosis based on a blood test
Kim Y, An J, Kim J, Chowdhury T, Yu H, Kim K, Kang H, Park C, Joung J, Park S, Kim D. Pyridine-NBD: A homocysteine-selective fluorescent probe for glioblastoma (GBM) diagnosis based on a blood test. Analytica Chimica Acta 2022, 1202: 339678. PMID: 35341522, DOI: 10.1016/j.aca.2022.339678.Peer-Reviewed Original ResearchCitationsAltmetricGenome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas
Hwang T, Kim S, Chowdhury T, Yu H, Kim K, Kang H, Won J, Park S, Shin J, Park C. Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas. Communications Biology 2022, 5: 62. PMID: 35042936, PMCID: PMC8766575, DOI: 10.1038/s42003-022-03011-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCircular RNA levelsI editingGenome-wide perturbationsPost-transcriptional processesPost-transcriptional regulationRNA expressionRNA levelsAlu expressionHuman genomeRNA-seqRegulatory elementsRepeat elementsGenetic elementsAlu subfamiliesBiological processesGrade 2 oligodendrogliomaAluExpressionGliomagenesisEditingUnique patternTranscriptomeGenomeSubfamiliesNormal tissuesSpatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
Kim A, Choi S, Park J, Kwon M, Chowdhury T, Yu H, Kim S, Kang H, Kim K, Park S, Park C, Shin E. Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma. OncoImmunology 2022, 11: 2026019. PMID: 35036078, PMCID: PMC8757477, DOI: 10.1080/2162402x.2022.2026019.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHigh-grade gliomasTumor immune microenvironmentTumor-associated macrophagesM2 tumor-associated macrophagesT cellsExhausted CD8Immune cellsImmunosuppressive cellsCTLA-4Hypoxic conditionsImmunosuppressive tumor immune microenvironmentProgression-free survivalRegulatory T cellsSurvival of patientsImmunosuppressive profilePD-1Patient survivalImmune microenvironmentImmune heterogeneityHypoxia signatureCD8Different biological featuresPatientsFlow cytometrySurvival
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