Jiang Yu
Postdoctoral AssociateAbout
Research
Publications
2024
Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation
Zhao S, Guo H, Qiu L, Zhong C, Xue J, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation. Scientific Reports 2024, 14: 12917. PMID: 38839811, PMCID: PMC11153636, DOI: 10.1038/s41598-024-61209-w.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesMarrow-derived macrophagesFoam cell formationMacrophage foam cell formationLipid-loweringCell formationApolipoprotein E-deficientHigh-fat diet feedingInhibit macrophage foam cell formationClinical management of atherosclerosisAtherosclerosis plaque formationAnti-atherosclerotic effectsAnti-inflammatory propertiesManagement of atherosclerosisClinical managementAttenuate inflammationLPS-induced inflammatory responseAllii Macrostemonis BulbusCD36 expressionTherapeutic strategiesIn vitro experimentsInflammatory responseAnti-coagulationE deficiencyHigh-fatAnemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation
Chu S, Shan D, He L, Yang S, Feng Y, Zhang Y, Yu J. Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation. Frontiers In Immunology 2024, 15: 1412022. PMID: 38881898, PMCID: PMC11176519, DOI: 10.3389/fimmu.2024.1412022.Peer-Reviewed Original ResearchVascular smooth muscle cellsAbdominal aortic aneurysmVascular smooth muscle cell dedifferentiationAbdominal aortic aneurysm formationAortic aneurysmMatrix metalloproteinasesVascular smooth muscle cell transdifferentiationAbdominal aortic aneurysms ManagementExpression of matrix metalloproteinasesIncreased expression of matrix metalloproteinasesSmooth muscle cellsDecreasing vascular inflammationInflammation in vitroModel in vivoAnemoside B4Macrophage-like cellsModel in vitroAAA developmentAbnormal dilatationChronic inflammationAAA pathogenesisVascular inflammationMuscle cellsEffects of anemoside B4MMP expressionEndothelial Mitochondria-Associated Membranes (MAMs) Isolation by Percoll Step Gradients
Baldini M, Zhang C, Yu J. Endothelial Mitochondria-Associated Membranes (MAMs) Isolation by Percoll Step Gradients. Methods In Molecular Biology 2024, 2782: 113-122. PMID: 38622396, DOI: 10.1007/978-1-0716-3754-8_8.Peer-Reviewed Original ResearchConceptsMitochondria-associated membranesEndoplasmic reticulumIntercellular adhesion molecule-1Vascular cell adhesion molecule-1Adhesion molecule-1Toll-like receptorsEndothelial cellsPercoll step gradientMolecule-1Pattern recognition receptorsLipid traffickingER stressCell adhesion molecule-1Innate immune cellsLevels of pattern recognition receptorsStep gradientSubcellular fractionsExpressing adhesion moleculesExpression levels of pattern recognition receptorsRecognition receptorsImmune cellsCalcium signalingExpression levelsEndothelial functionE-selectinSaponins from Allium macrostemon Bulbs Attenuate Endothelial Inflammation and Acute Lung Injury via the NF-κB/VCAM-1 Pathway
Liu L, Qiu L, Xue J, Zhong C, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allium macrostemon Bulbs Attenuate Endothelial Inflammation and Acute Lung Injury via the NF-κB/VCAM-1 Pathway. Molecules 2024, 29: 1239. PMID: 38542876, PMCID: PMC10976117, DOI: 10.3390/molecules29061239.Peer-Reviewed Original ResearchConceptsVascular cell adhesion molecule-1Acute lung injuryEndothelial inflammationLung injuryNF-kBAugmented expression of adhesion moleculesLung injury in vivoAcute lung infectionAcute lung injury in vivoExpression of adhesion moleculesSecretion of pro-inflammatory cytokinesVascular cell adhesion molecule-1 expressionTumor necrosis factor-aCell adhesion molecule-1Septic acute lung injuryNF-kB p65 phosphorylationAdhesion molecule-1Coronary artery diseaseInjury in vivoPro-inflammatory cytokinesHuman umbilical vein endothelial cellsInflammatory mediators lipopolysaccharideExpression of pro-inflammatory factorsUmbilical vein endothelial cellsPro-inflammatory factorsEdgeworthia gardneri (Wall.) Meisn. Ethanolic Extract Attenuates Endothelial Activation and Alleviates Cardiac Ischemia-Reperfusion Injury
Lang X, Zhong C, Su L, Qin M, Xie Y, Shan D, Cui Y, Shi M, Li M, Quan H, Qiu L, Zhong G, Yu J. Edgeworthia gardneri (Wall.) Meisn. Ethanolic Extract Attenuates Endothelial Activation and Alleviates Cardiac Ischemia-Reperfusion Injury. Molecules 2024, 29: 1068. PMID: 38474581, PMCID: PMC10935089, DOI: 10.3390/molecules29051068.Peer-Reviewed Original ResearchConceptsExtracellular regulated protein kinasesEndothelium activationMitogen-activated protein kinaseI/R injuryEndothelial cellsCardiac ischemia-reperfusion injuryIschemia-reperfusion (I/RAdhesion to endothelial cellsIschemia-reperfusion injuryExpression of pro-inflammatory mediatorsNuclear factor kappa BCardiac I/R injuryPro-inflammatory mediatorsIn vivo findingsP38 mitogen-activated protein kinaseFactor kappa BPro-inflammatory activityI/R-induced inflammationMyocardial I/R injuryEndothelial activationCardiac injuryC-Jun <i>N</i>-terminal kinase (JTherapeutic efficacyFirm adhesion to endothelial cellsProtein kinase
2023
Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice
Zhong C, Yang J, Deng K, Lang X, Zhang J, Li M, Qiu L, Zhong G, Yu J. Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice. Molecules 2023, 28: 7527. PMID: 38005247, PMCID: PMC10673355, DOI: 10.3390/molecules28227527.Peer-Reviewed Original ResearchConceptsAMP-activated protein kinaseNLRP3 inflammasome activationInflammasome activationReduction of mitochondrial reactive oxygen speciesMitochondrial reactive oxygen speciesMultiprotein signaling complexesMitochondrial membrane potentialImprovement of mitochondrial membrane potentialNLRP3-related diseasesAmeliorating mitochondrial damageSignaling complexProtein kinaseReactive oxygen speciesRegulating NLRP3 inflammasome activationNLRP3 inflammasomeMitochondrial damageInnate immunityDysregulated NLRP3 inflammasome activationAttenuated NLRP3 inflammasome activationNOD-like receptor family pyrin domainMembrane potentialOxygen speciesPyrin domainFamily pyrin domainDietary plantsTiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice
Yi X, Xu C, Yang J, Zhong C, Yang H, Tang L, Song S, Yu J. Tiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice. International Journal Of Molecular Sciences 2023, 24: 15556. PMID: 37958538, PMCID: PMC10648967, DOI: 10.3390/ijms242115556.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLPS-induced acute kidney injuryIntrarenal renin-angiotensin systemRenin-angiotensin systemTubular cell apoptosisAng IIKidney injuryPlasma Ang IIKidney injury markersAmeliorated renal dysfunctionCell apoptosisMale C57BL/6 miceSeveral inflammatory diseasesLPS-injected miceOxidative stressLPS-induced AKI miceLipopolysaccharide (LPS)-induced acute kidney injuryInhibiting oxidative stressRenal dysfunctionRenal expressionRenoprotective actionC57BL/6 miceRenoprotective effectsFibrosis markersInjury markersDifferential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice
Xu C, Yi X, Tang L, Wang H, Chu S, Yu J. Differential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice. American Journal Of Physiology. Renal Physiology 2023, 325: f503-f518. PMID: 37589054, DOI: 10.1152/ajprenal.00018.2023.Peer-Reviewed Original ResearchConceptsUrine-concentrating capabilityAquaporin-2Renal cortexAngiotensin-converting enzymeAng IIDownregulation of aquaporin-2Mechanism of autophagyEffect of autophagyRenal pathophysiologyWater deprivationRenal AQP2 expressionRenal aquaporin-2Function of autophagyRegulation of autophagyUrine-concentrating abilityRenin-angiotensin systemKidneys of miceAQP2 expressionAldosterone levelsWD miceAngiotensin IICapability of miceRapa administrationRenal medullaMiceEffects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny
Li Y, Johnson J, Yang Y, Yu D, Kubo H, Berretta R, Wang T, Zhang X, Foster M, Yu J, Tilley D, Houser S, Chen X. Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny. AJP Heart And Circulatory Physiology 2023, 325: h702-h719. PMID: 37539452, PMCID: PMC10659327, DOI: 10.1152/ajpheart.00320.2023.Peer-Reviewed Original ResearchConceptsTransverse aortic constrictionMaternal hypothyroidismCM proliferationIn vitro studiesPressure overloadAdult heartDisease responseEffects of maternal hypothyroidismPathological remodelingHeart weightCM numbersBone morphogenetic protein 10Postnatal cardiomyocyte proliferationIn vivoBody weightProgeny of mothersCardiac pathological remodelingCardiac myocytesMyocyte proliferationPostnatal dayAortic constrictionPostnatal cardiomyocytesProtein 10Synthetic thyroxinePostnatal developmentPulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization
Yang X, Wu M, Yan X, Zhang C, Luo Y, Yu J. Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization. Molecules 2023, 28: 3682. PMID: 37175092, PMCID: PMC10179893, DOI: 10.3390/molecules28093682.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesAnti-tumor effectsM2 macrophage polarizationAnti-tumor activityB16-F0 cellsPolarization of M2 macrophagesTumor progressionMacrophage polarizationExpression of M2 marker genesIn vivoM2 macrophagesConditioned mediumLung metastasis of melanomaIn vitroPhosphorylated STAT6Bone marrow suppressionMRNA levelsMetastasis of melanomaSuppress tumor progressionDown-regulationMarrow-derived macrophagesMetastasis of tumorsSTAT6 signaling pathwayMarrow suppressionM2 marker genes