Henk De Feyter, PhD
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About
Titles
Associate Professor of Radiology and Biomedical Imaging
Appointments
Radiology & Biomedical Imaging
Associate Professor on TermPrimary
Other Departments & Organizations
- Bioimaging Sciences
- Deuterium Metabolic Imaging (DMI)
- Developmental Therapeutics
- Magnetic Resonance Research Center
- Magnetic Resonance Spectroscopy
- Radiology & Biomedical Imaging
- Yale Cancer Center
Education & Training
- Postdoctoral Associate
- Yale University (2010)
- PhD
- Eindhoven University of Technology, Department of Biomedical Engineering
- MSc
- Maastricht University, Department of Health, Medicine and Life Sciences
- MSc
- Ghent University, DEPARTMENT OF REHABILITATION SCIENCES
Research
Overview
Medical Subject Headings (MeSH)
Biomarkers, Tumor; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways
ORCID
0000-0001-6111-0316
Research at a Glance
Yale Co-Authors
Frequent collaborators of Henk De Feyter's published research.
Publications Timeline
A big-picture view of Henk De Feyter's research output by year.
Research Interests
Research topics Henk De Feyter is interested in exploring.
Robin de Graaf, PhD
Richard Carson, PhD
Anita Huttner, MD
Barbara Gulanski, MD, MPH
Gregory A Breuer, MD/PhD
Yiyun Huang, PhD
23Publications
1,366Citations
Magnetic Resonance Spectroscopy
Publications
2024
Lipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Lipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge. Magnetic Resonance 2024, 5: 21-31. DOI: 10.5194/mr-5-21-2024.Peer-Reviewed Original ResearchAltmetric
2023
Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma
Khang M, Lee J, Lee T, Suh H, Lee S, Cavaliere A, Rushing A, Geraldo L, Belitzky E, Rossano S, de Feyter H, Shin K, Huttner A, Roussel M, Thomas J, Carson R, Marquez-Nostra B, Bindra R, Saltzman W. Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma. Science Translational Medicine 2023, 15: eadi1617. PMID: 37910601, PMCID: PMC11078331, DOI: 10.1126/scitranslmed.adi1617.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebrospinal fluidDelivery of drugsEffective therapyTherapeutic indexPARP inhibitorsBlood-brain barrierSite of tumorRapid systemic clearanceXenograft mouse modelSolvent evaporation processAdministration of substancesLeptomeningeal spreadIntrathecal deliveryLeptomeningeal metastasesBrain penetrationSystemic clearanceTumor regressionPolymer nanoparticlesMetastatic medulloblastomaMouse modelPediatric medulloblastomaDrug accumulationCSF turnoverEncapsulated drugsPET imagingMapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)
Ip K, Thomas M, Behar K, de Graaf R, De Feyter H. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI). Frontiers In Cellular Neuroscience 2023, 17: 1130816. PMID: 37187610, PMCID: PMC10175635, DOI: 10.3389/fncel.2023.1130816.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBrain tumorsNormal brainHigh tumorCholine uptakeRG2 cellsCholine infusionMetabolic imagingExogenous cholineMetabolic imaging techniquesDeuterium metabolic imagingIntravenous infusionRG2 tumorsTumor lesionsAnimal modelsCholine metabolismTumorsInfusionRat glioblastomaIntracellular cholineFree cholineHigh uptakeLesionsCholineRatsDeuterated cholinePreclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
Chen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPositron emission tomographyHealthy nonhuman primatesVolume of distributionDistribution volume ratioBrain kineticsRat glioblastoma modelPreclinical evaluationBrain regionsGlioblastoma modelPET tracersNonhuman primatesTumor-bearing ratsEx vivo biodistributionPET imaging resultsActive clinical trialsTreatment of glioblastomaHigh specific uptakeDynamic PET scansNoninvasive quantificationBrain positron emission tomographyNondisplaceable volumeBrain penetrationLow nonspecific uptakePrognostic informationClinical trialsIn vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
2022
Deuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDeuterium Metabolic Imaging of the Human Brain in vivo at 7T
Roig E, De Feyter H, Nixon T, Ruhm L, Avdievich N, Henning A, de Graaf R. Deuterium Metabolic Imaging of the Human Brain in vivo at 7T. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/0635.Peer-Reviewed Original Research
2021
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Reports 2021, 36: 109475. PMID: 34320362, DOI: 10.1016/j.celrep.2021.109475.Peer-Reviewed Original ResearchCitationsAltmetricDeuterium metabolic imaging – Back to the future
De Feyter HM, de Graaf RA. Deuterium metabolic imaging – Back to the future. Journal Of Magnetic Resonance 2021, 326: 106932. PMID: 33902815, PMCID: PMC8083995, DOI: 10.1016/j.jmr.2021.106932.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricNMR visibility of deuterium‐labeled liver glycogen in vivo
De Feyter HM, Thomas MA, Behar KL, de Graaf R. NMR visibility of deuterium‐labeled liver glycogen in vivo. Magnetic Resonance In Medicine 2021, 86: 62-68. PMID: 33590529, PMCID: PMC8005460, DOI: 10.1002/mrm.28717.Peer-Reviewed Original ResearchCitationsAltmetric
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