John MacMicking, PhD
Biography
Research & Publications
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Appointments
Biography
John MacMicking is a Howard Hughes Medical Institute (HHMI) Investigator, Professor of Microbial Pathogenesis and Professor of Immunobiology. He trained in synthetic organic chemistry at the Australian National University (B.Sc, 1st Class Honors) where he conducted thesis work in the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the John Curtin School of Medical Research.
He then came to the U.S. to pursue Ph.D studies with Carl Nathan in the Immunology program at Cornell University-Sloan-Kettering Institute in New York City before being selected as an HHMI Life Science Research Foundation Fellow at The Rockefeller University to conduct studies with John McKinney.
His doctoral dissertation described the first knockout of an interferon (IFN)-induced defense protein in eukaryotes - inducible nitric oxide synthase (iNOS) - engineered between 1992-1995. It served as an early paradigm for cell-autonomous innate immunity to bacterial, viral and protozoan infections. At Rockefeller University he computationally identified, physically mapped and began functionally characterizing a complete IFN-inducible GTPase superfamily in humans and mice as a new defense network operating against all pathogen classes. For these discoveries he was named a Edward Mallinckrodt Jr Foundation Fellow (2004), Searle Scholar (2005), Cancer Research Institute Investigator (2006), Burroughs-Wellcome Fund Investigator (2008), CCFA Senior Research Awardee (2010), AAF Scholar (2014), and Kenneth Rainin Foundation Innovator (2014). In 2022, he received the Alumni Award of Distinction (Medical Sciences) from Cornell University.
Dr. MacMicking was promoted to Associate Professor in 2010 and tenured in 2014. He was chosen as an HHMI Investigator in 2015 before moving to the Yale Systems Biology Institute in 2017.
Education & Training
- Assistant Professor (Adjunct)The Rockefeller University (2007)
- Research AssociateThe Rockefeller University (2003)
- HHMI LSRF FellowThe Rockefeller University (2000)
- Revson Biomedical FellowThe Rockefeller University (1998)
- PhDCornell University (1997)
- BSc (Hon)Australian National University (1990)
Activities
- Austrian Science FundVienna, Vienna, Austria 2017International Reviewer
- The Wellcome TrustLondon, England, United Kingdom 2016International Reviewer, Public Health & Tropical Medicine
- The Wellcome Trust/DBT India AllianceNew Delhi, DL, India 2015International Reviewer
- Swiss National Research FoundationBern, BE, Switzerland 2014International Reviewer, Biology and Medicine (Division III)
- German Research Foundation (DFG)āØBonn, North Rhine-Westphalia, Germany 2013International Reviewer, Life Sciences 2 Programme
- French National Research Agency (ANR)Paris, Ile-de-France, France 2012International Reviewer, Programme Blanc International
- Health Research Board of Ireland (HRB)Dublin, Leinster, Ireland 2011International Reviewer, Translational Medicine Fellowships Programme
- European Research Council (ERC)Brussels, Brussels Capital Region, Belgium 2011International Reviewer, European Union 7th Research Framework Advanced Grants Programme (FP7)
- Medical Research Council (MRC)London, England, United Kingdom 2009International Reviewer, Strategic Grants Programme
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
Alumni Award of Distinction | Cornell University | 2022 |
Investigator | Howard Hughes Medical Institute (HHMI) | 2015 |
Innovator Award | Kenneth Rainin Foundation | 2014 |
Scholar Award | American Asthma Foundation (AAF) | 2014 |
Senior Investigator Award | Crohnās and Colitis Foundation of America (CCFA) | 2010 |
Investigator in the Pathogenesis of Infectious Disease Award | Burroughs Wellcome Fund (BWF) | 2008 |
Investigator Award | Cancer Research Institute (CRI) | 2006 |
Searle Scholar Award | Searle-Chicago Community Trust | 2005 |
Edward Mallinckrodt, Jr. Foundation Fellow | Yale University | 2004 |
Howard Hughes Medical Institute Life Science Research Foundation (LSRF) Fellow | The Rockefeller University | 1998 |
Charles H. Revson Fellow in Biomedical Research | The Rockefeller University | 1997 |
Distinguished Student Commencement Speaker Award | Cornell University, New York, NY | 1997 |
Professional Service
Organization | Role | Date |
---|---|---|
Advisory Council, Searle Scholars Program | Scientific board member | 2022 - Present |
Journal of Experimental Medicine | Editorial Advisory Board | 2022 - Present |
Cellular Microbiology | Editorial Advisory Board | 2017 - 2021 |
American Society of Microbiology (Immunology division) | Chair and Chair-Elect, Immunology Division | 2014 - 2016 |
NIAID, NIH | Standing member, Immunity and Host Defense (IHD) Study Section | 2013 - 2015 |
Proceedings National Academy of Sciences USA | Guest Editor | 2013 - Present |