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Jon Koff, MD

Associate Professor Term
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Additional Titles

Associate Director, Fellowship Research, Pulmonary, Critical Care & Sleep Medicine

Medical Director, Center for Phage Biology & Therapy, Yale University

Director, Adult Cystic Fibrosis Program

About

Titles

Associate Professor Term

Associate Director, Fellowship Research, Pulmonary, Critical Care & Sleep Medicine; Medical Director, Center for Phage Biology & Therapy, Yale University; Director, Adult Cystic Fibrosis Program

Biography

Dr. Koff received his undergraduate degree from Hamilton College and his medical degree from Case Western Reserve University. He completed residency training in Internal Medicine at Brown University. He then completed fellowship training in Pulmonary & Critical Care Medicine at the University of California, San Francisco (UCSF). This included research in the Cardiovascular Research Institute in the laboratory of his mentor, Jay A. Nadel, M.D., and dedicated fellowship training in adult cystic fibrosis and lung transplantation. In 2011, Dr. Koff joined the faculty at Yale University to Direct the Adult Cystic Fibrosis Program and to continue his research that focuses on pulmonary innate immunity. Dr. Koff is Medical Director of Yale's Center for Phage Biology & Therapy in which he focuses on bacteriophage therapy for multi-drug resistant infections.

Appointments

Other Departments & Organizations

Education & Training

Fellowship
University of California - San Francisco (2008)
Fellowship
University of California - San Francisco (2008)
MD
Case Western Reserve University School of Medicine (2000)
BA
Hamilton College, World Politics

Research

Overview

Medical Subject Headings (MeSH)

Asthma; Bacteriophages; Bronchiectasis; Cystic Fibrosis; Immunity, Innate; Immunity, Mucosal; Influenza, Human; Lung; Respiratory Mucosa; Viruses

Research at a Glance

Yale Co-Authors

Frequent collaborators of Jon Koff's published research.

Publications

2024

2023

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

  • activity

    American Journal of Respiratory Cell and Molecular Biology, American Journal of Physiology- Lung Cellular and Molecular Physiology, Cytokine, Drugs, Journal of Cystic Fibrosis, Thorax, European Respiratory Journal

  • activity

    American Thoracic Society

  • activity

    American Thoracic Society, Respiratory, Cell, and Molecular Biology Assembly Mentoring Program

  • activity

    Board of Directors, Connecticut Chapter of the Cystic Fibrosis Foundation

  • activity

    P30 CF Research and Translation External Advisory Board

Clinical Care

Overview

Jonathan Koff, MD, a pulmonary and critical care physician, is director of the Yale Medicine Adult Cystic Fibrosis Program. He chose pulmonary medicine in part because his grandfather had emphysema. “I wanted to better understand how the disease affected him,” he says.

Dr. Koff was drawn to cystic fibrosis, which is usually diagnosed in childhood, because he was intrigued by the complexity of this genetic disease, which causes recurrent lung infections, and digestive and nutritional problems, among other issues. He works with a multidisciplinary team that includes a nurse, a nutritionist, a physical therapist, a social worker, and respiratory therapists. “We continue to see our patients do better clinically with the multidisciplinary team-based care approach,” he says. He is optimistic about new treatments for cystic fibrosis, such as recently approved therapies that target specific genetic mutations.

An associate professor of medicine (pulmonary) at Yale School of Medicine, Dr. Koff also works in the medical intensive care unit at Yale New Haven Hospital, and conducts laboratory and translational research that focuses on viral infections in asthma and cystic fibrosis. He serves on the board of the Connecticut Chapter of the Cystic Fibrosis Foundation.

Clinical Specialties

Pulmonology & Sleep Medicine; Pulmonary Critical Care

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