The airways are continuously exposed to pathogens, allergens, toxins, and environmental contaminants. In addition to its role as a physical barrier, the airway epithelial surface represents a “battleground,” where the host intercepts signals from pathogens (e.g., viruses and bacteria) and activates epithelial defenses to prevent infection.

Current Projects

  1. Utilize the cellular mechanisms discovered by investigating airway epithelial viral infection to target molecules in cystic fibrosis airway epithelium and lung.
  2. Investigating novel viral mechanisms may provide targets for novel therapies.