The Yale Liver Center

The Yale Liver Center is one of 18 Digestive Diseases Research Core Centers (DDRCCs) supported by NIH/NIDDK. The Yale Liver Center has been funded continuously since 1984 and is one of only four that focus on the liver. The Yale Liver Center supports investigation of liver structure, function and disease. Research support is provided through the Center’s Four Core Facilities, as well as through Pilot Feasibility Projects that are offered annually.

The research base focuses on six major areas:

  • Basic Liver Biology and Pathobiology
  • Bile Secretion and Cholestasis
  • Fibrosis and Cirrhosis
  • Liver Cancer
  • Liver Infection, Inflammation, and Immunobiology
  • Metabolism and Steatosis

More than seventy-five independent principal investigators are members of the Center which involves over 20 departments at Yale including, but not limited to: Biomedical and Chemical Engineering; Cell Biology; Cellular and Molecular Physiology; Comparative Medicine; School of Public Health; Human Genetics; Immunobiology; Laboratory Medicine; Internal Medicine; Microbial Pathogenesis; Molecular, Cellular and Developmental Biology; Pathology; Pediatrics; Pharmacology; Radiology; Transplant and Surgery.

The Liver Center also supports weekly research seminars (on Tuesday afternoons) and clinical lectures (on Friday afternoons), in conjunction with the Section of Digestive Diseases, Department of Internal Medicine.


Michael H. Nathanson, M.D., Ph.D.
Michael H. Nathanson, M.D., Ph.D.
Director, Liver Center more...