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Completed Pilot Projects


Recipient Project Title
Jane-Wit, Daniel, MD, PhD (Cardiovascular Medicine) Role of Cholangiocyte Derived Wnts During Cholestatic Injury
Mezzacappa, Catherine, MD, MPH (Digestive Diseases) Changes in DNA methylation as markers of fatty liver disease progression


Recipient Project Title
Bini, Jason, PhD (Radiology & Biomedical Imaging) Positron Emission Tomography imaging of 11β-hydroxysteroid dehydrogenase type 1 in NAFLD
Gupta, Vikas, MD, PhD (Digestive Diseases) Role of Cholangiocyte Derived Wnts During Cholestatic Injury
Huh, Won Jae, MD, PhD (Pathology) Sex-Hormone-Induced Differential Expression of EGF Receptor (EGFR) in Hepatocytes and Its Implication for Hepatic Steatosis
Yang, Xiaoyong, PhD (Comparative Medicine) Characterizing novel paracrine factors in chronic liver disease


Recipient Project Title
BiniAssis, David, MD (Digestive Diseases) A pilot study of a novel bacteriophage approach to target pathogenic gut-derived bacteria in patients with Primary Sclerosing Cholangitis
Mak, Michael, PhD (Biomedical Imaging) Mechanobiology-Driven Heterogeneity and Therapeutic Resistance in Liver Cancer
McConnell, Matthew, MD (Digestive Diseases) The Role of Platelets in the Pathogenesis of Alcohol-Related Hepatitis
Vilarinho, Silvia, MD (Digestive Diseases) mRNA-based therapeutics for liver disease: a pilot study


Recipient Project Title
BiniCai, Shi-Ying, PhD (Digestive Diseases) Role of Ca2+/NFAT signaling pathway in cholestatic liver injury
Onofrey, John, PhD (Radiology & Biomedical Imaging) Automated Hepatic Lesion Detection and LI-RADS Prediction using Deep Learning for Clinical Decision Support
Weerachayaphorn, Jittima PhD (Digestive Diseases) Role of inositol 1,4,5-trisphosphate receptors in alcoholic hepatitis


Recipient Project Title
Amenduni, Mariangela, PhD (Digestive Diseases) Use of hiPSCs to study the function of CFTR mutations in cholangiocyte innate immunity
Boddupalli, Venkata, PhD (Digestive Diseases) Delineating the role tissue resident T cells in mediating immunopathology of PSC-IBD
Ouyang, Xinshou, PhD (Digestive Diseases) RNA methylation landscaping of gene regulation in macrophage-mediated inflammation in NASH
Tietjen, Gregory, PhD (Surgery: Transplant) Personalized diagnostic profiling of donor livers during ex vivo perfusion
Wang, Steven (Siyuan), PhD (Genetics and Cell Biology) Imaging-based 3D genomics and transcriptomics in aging liver


Recipient Project Title
Bhat, Neha, PhD (Cardiovascular Research Center) Characterizing the pathophysiology of metabolic syndrome upon genetic manipulation of Dyrk1b in the liver
Iwakiri, Yasuko, PhD (Digestive Diseases) Lymphangiogenesis in the liver
Joshi, Nikhil, PhD (Immunobiology) Understanding mechanisms of hepatocyte-induced T cell immunologic tolerance
Kulkarni, Supriya, PhD (Digestive Diseases) Identification and characterization of OSTα/β inhibitors for drug therapy in cholestasis
Soroka, Carol, PhD (Digestive Diseases) Isolation of Organoids from Bile of Patients with Primary Sclerosing Cholangitis Provides a Unique Opportunity to Study Extrahepatic Biliary Cells Throughout the Progression of the Disease


Recipient Project Title
Soroka, Carol, PhD (Digestive Diseases) Use of Human Organoids in the Study of Liver Disease: A Model for Maintaining PSC Patient Progenitor Cells in Long-term Culture with the Potential Ability to Screen for the Efficacy of Drug Therapies
Mani, Arya, MD (Cardiovascular Genetics) Investigation of liver disease in mice with impaired TCF7L2 function
Arterbery, Adam, PhD (Pediatrics) The role of Inflammasome activity and the induction of the Unfolded Protein Response in the immune pathogenesis of T cells in de novo autoimmune hepatitis (DAIH) following liver transplantation”
Peters, Dana, PhD (Radiology and Biomedical Imaging) Magnetic Resonance biomarkers of Acidosis in Liver Tumor Microenvironment”
Fiorotto, Romina, PhD (Digestive Diseases) CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease


Recipient Project Title
Chen, Ying, PhD (Public Health) Redox-based regulatory role of glutathione in the pathogenesis of fatty liver disease
Vilarinho, Silvia, MD (Digestive Diseases) Genomic Architecture of Biliary Atresia
Fiorotto, Romina, PhD (Digestive Diseases) CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease
Ben Mamoun, Choukri, PhD (Infectious Diseases) Elucidating the role of the solute transporter OSTα/SCL51A In malaria infection


Recipient Project Title
Koff, Jonathan, MD (Pulmonary, Critical Care, and Sleep Medicine) Hepatitis C virus activates EGFR to suppress antiviral immunity
Lomakin, Ivan, PhD (Molecular Biophysics and Biochemistry) The structural characterization of the HCV IRES with the ribosome
Ruan, Hai-Bin, PhD (Biology and Physiology) CaMKII signaling regulates liver autophagy through Ulk1 O-G1cNAcylation
Kibbey, Richard, MD, PhD (Endocrionology, Cellular and Molecular Physiology) Direct measurement of hepatic PEPCK-M-Dependent Transmitochondrial Fluxes
Finberg, Karin, MD (Pathology) Effect of Vitamin D on Hepatic Regulation of Systemic Iron Balance


Recipient Project Title
Ouyang, Xinshou, PhD (Digestive Diseases) Downregulation of HIF-1α to limit inflammasome mediated acute liver injury
Robek, Michael, PhD (Pathology) A new humanized mouse model of chronic hepatitis B
Lee, Hochang, MD (Psychiatry) Flumazenil treatment of HE and Changes in cortical GABA levels
Ekong, Udeme, MD, PhD (Pediatrics) The role of pathogenic Th17 cells in de novo autoimmune hepatitis

Publication Acknowledgment

To cite the Liver Center in your publications please use the following statement:

”This project was supported in part by the Yale Liver Center award NIH P30 DK034989 ________ core.”
(insert name of core(s) that you used-Morphology, Cellular Molecular, Clinical-Translational)