2020
Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis
Choi H, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor M, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper J, Melenovský V, Čiháková D. Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Reports 2020, 30: 2989-3003.e6. PMID: 32130902, PMCID: PMC7332109, DOI: 10.1016/j.celrep.2020.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementChemokine CCL11Disease SusceptibilityEosinophilsFemaleFibroblastsGene Expression RegulationHeartHeart Function TestsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-5LymphocytesMaleMediastinumMice, Inbred BALB CPericarditisSignal TransductionUp-RegulationConceptsInnate lymphoid cellsEosinophilic pericarditisPathogenic roleMediastinal cavityLymphoid cellsGroup 2 innate lymphoid cellsCardiac fibroblastsDevelopment of pericarditisCardiac inflammationEotaxin-1Healthy controlsPericardial fluidCardiac diseasePericarditisB cellsSerous cavitiesILC2sEosinophilsPatientsMiceHeartCellsCritical roleFibroblastsInflammation
2019
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCell ProliferationC-Mer Tyrosine KinaseDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalae
2017
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran W, Čiháková D. Cardiac Autoimmunity: Myocarditis. Advances In Experimental Medicine And Biology 2017, 1003: 187-221. PMID: 28667560, PMCID: PMC5706653, DOI: 10.1007/978-3-319-57613-8_10.Peer-Reviewed Original ResearchConceptsAutoimmune processAdaptive T cell responsesGiant cell myocarditisT cell responsesVariable clinical presentationMonocytes/macrophagesImmunopathogenic featuresAcute complicationsAutoimmune myocarditisSystolic dysfunctionAcute myocarditisCryptic antigensHemodynamic complicationsHeart failureTreg inductionClinical presentationElectrophysiologic disturbancesHumoral responseClinical correlatesDifferent etiologiesInflammatory processImmune responseMyocarditisSpecific cytokinesChronic damage