Research
Research in Allergy & Immunology at Yale encompasses a wide range of basic, translational, and clinical research on allergic and immunologic diseases. It involves both pediatric and adult populations, as we provide integrated adult and pediatric care in all aspects of allergy and immunology. We have a particular interest in studying the functions of B and T cells in adult and pediatric immune deficiencies, autoimmunity, and allergy, as we have the ability to take blood samples from patients to the laboratory for phenotypic and functional analyses of immune cells. Some of our faculty have also been involved in clinical research, including clinical trials for pharmacotherapeutics.
Adult Allergy & Immunology Faculty
Ami Belmont, MD
Dr. Belmont's research interests include drug allergy epidemiology and the intersection between antibiotic allergy labels and antibiotic stewardship. She is interested in designing interventions to promote the application of evidence-based practices for patients with antibiotic allergy labels. Active projects include studying interventions to increase utilization of cephalosporins in patients with penicillin allergy labels, validating variables in the EMR for drug allergy, and mixed method research (employing implementation science) examining risks associated with antibiotic allergy labels in patients with stem cell transplants. She also serves as the Yale site PI for the United States Drug Allergy Registry (USDAR).
Insoo Kang, MD
The research interest of Dr. Kang’s laboratory is to understand the human immune system in health and disease including autoimmunity, inflammation, immunosenescence, primary immunodeficiency and atopic diseases using biological samples and clinical data. In particular, Dr. Kang’s lab has defined subsets of T cells with distinct cellular characteristics based on the expression of cytokine receptors on T cells in health and disease as well as the interactions of such cell subsets with monocytes and other immune cells.
John Kuster, MD
Dr. Kuster’s research interests include leveraging genetic testing in immunodeficiency to help identify specific disease associated variants. Identification of these particular pathways have the potential for furthering our understanding of immunodeficiency, and possible future targeted therapies.
Elise Liu, MD, PhD
Dr. Liu’s research focuses on understanding the production and role of gut immunoglobulin A in food allergy.
Christina Price, MD
Dr. Price's research goals are to understand the relationship between autoimmunity, immune deficiency and tumor immunology. She developed the clinical immunology-oncology program and is establishing databases and biorepositories of patients on immune modulators with the collaborative effort between the internal medicine subspecialists who are treating immune related adverse events from immune modulators.
Junghee Jenny Shin, MD, PhD
Dr. Shin joined Dr. Insoo Kang’s laboratory in 2018. Her research focuses on characterizing clinical phenotypes of patients with primary immune deficiencies and immune dysregulation using in-depth immune profiling techniques. Dr. Shin’s overall research goal is understanding how immune alterations occur and affect the pathogenesis of such disorders in relation to their genetic defects, clinical presentations and comorbidities.
Ryan Steele, DO
Dr. Steele cares for patients in the full range of allergic and immunologic diseases. Prior to entering full time academic practice, he conducted post-doctoral research focusing on small peptide therapeutics for auto-immune diseases, as well as work elucidating the mechanisms behind anti-IgE therapy in chronic urticaria. Most recently he started the Yale Allergy & Immunology Contact Dermatitis Program, where he serves as Program Director, and conducts clinical research into allergic skin diseases.
Florence Ida Hsu, MD
Dr. Hsu has participated over the years in a variety of clinical trials for pharmacotherapeutics in hereditary angioedema and chronic rhinosinusitis. She has published on the safety and efficacy of several rapid drug desensitization protocols and helps to identify patients for clinical studies within our section. Dr. Hsu also collaborates with researchers around the country on other observational clinical studies in hereditary angioedema.
Pediatric Allergy & Immunology Faculty:
Julie Flom, MD, MPH
Dr. Flom’s clinical and research interests include understanding early life risk factors and underlying mechanisms for development of pediatric allergic diseases including food allergy, asthma, eczema, and environmental allergies, and applications to prevention and treatment of allergic disease.
Kelsey Kaman, MD
The “Learn Early Project” aims to improve food allergy education and outcomes among Black, Hispanic or low socio-economic status children. We have partnered with Head Start centers across Connecticut in hopes of ensuring all children with food allergies can grow and develop in a safe and healthy environment.
Stephanie Leeds, MD
Dr. Leeds has a research interest in food allergy. She has created the first food allergy ECHO (Extension for Community Health Outcomes) model™, in which she facilitated food allergy education and case-based discussions with community pediatricians through teleECHO™ clinics. She has also worked with the iREACH (Intervention to Reduce Early Peanut Allergy in Children) team to develop an innovative, interactive national curriculum of peanut allergy prevention. Outside of food allergy education work, Dr. Leeds’ food allergy research is also clinical and translational, with studies looking at early oral immunotherapy, food allergen presentation within matrices, and potential food allergy prevention signals through maternal diet and comorbid disease states.
Gary Soffer, MD
Dr. Soffer’s research interests focus on integrative medicine and the intersection of allergies and immunity.
Katelyn Wong, MD
Dr. Wong’s research interests include improvement of patient care in allergic conditions through quality improvement and education.
Fellows in our A&I training program have also worked with faculty in other departments including:
-
Geoffrey Chupp, MD -
Yale Center of Asthma and Airway Disease (YCAAD) Research Program
- Carrie Lucas, Ph.D. - Lucas Lab
- Noah Palm, Ph.D. - Palm Lab
- Stephanie Eisenbarth, MD, PhD - Eisenbarth Lab
- Eric Meffre, PhD
Additional faculty with laboratory research related to Allergy & Immunology can be found in the Department of Immunobiology.
Research Faculty
Associate Professor Adjunct
Research Interests- Allergy and Immunology
- Asthma
- Blood Group Incompatibility
- Food Hypersensitivity
- Immune System Diseases
Professor; Director of Allergy & Immunology, Internal Medicine
Research Interests- Aging
- Inflammation
- Rheumatology
- T-Lymphocytes
- Autoimmunity
Assistant Professor (Rheumatology, Allergy & Immunology); Assistant Program Director A&I Fellowship, Allergy and Immunology
Assistant Professor of Pediatrics (Immunology)
Research Interests- Food Hypersensitivity
- Pediatrics
Associate Professor of Medicine (Allergy & Immunology); Clinical Chief of Allergy and Immunology, Rheumatology, Allergy, & Immunology; VA Medical Center Section Chief, Allergy and Clinical Immunology, VA Medical Center
Assistant Professor; Director, Primary Immunodeficiency Program
Assistant Professor; Director, Integrative Medicine Progam; Associate Program Director, Pediatric Residency Program
Associate Professor of Internal Medicine (Rheumatology)
Research Interests- Inflammation
- Metabolism
- Psychoneuroimmunology
- Neuroimmunomodulation