Immune Profiling

Individual variations in immune status determine responses to infection and contribute to disease severity and outcome. These variations contribute to susceptibility to autoimmune diseases and may contribute to clinical expression and response to therapy. To define immune signatures that are associated with specific clinical manifestations of diseases, we profile multiple aspects of cell functions, using primary cells of well-defined patient cohorts. We have developed reproducible methods for primary cells and small sample sizes to identify cell types, responses to treatment, and functional mechanisms. Our overall goal is to delineate predictive immune signatures important for understanding diverse states of disease such as mild vs severe disease, isolated organ involvement vs systemic disease, remission vs flare, young vs old.