2024
The protective role of GATA6+ pericardial macrophages in pericardial inflammation
Hughes D, Won T, Talor M, Kalinoski H, Jurčová I, Szárszoi O, Stříž I, Čurnová L, Bracamonte-Baran W, Melenovský V, Čiháková D. The protective role of GATA6+ pericardial macrophages in pericardial inflammation. IScience 2024, 27: 110244. PMID: 39040070, PMCID: PMC11260870, DOI: 10.1016/j.isci.2024.110244.Peer-Reviewed Original ResearchMyocardial infarctionMyocardial inflammationPericardial inflammationTrafficking of inflammatory monocytesCoxsackievirus B3-induced myocarditisUpregulation of inflammatory markersPreventing interstitial fibrosisCardiac function post-MIStimulated in vitroFunction post-MIInduced pericarditisInflammatory monocytesInflammatory markersBone marrowInterstitial fibrosisCardiac fibrosisAttenuated traffickingPost-MIInflammationInduced upregulationFibrosisMacrophagesGATA6Pericardial cavityCoxsackievirus B3
2019
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCell ProliferationC-Mer Tyrosine KinaseDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalae