2019
Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
Bracamonte-Baran W, Chen G, Hou X, Talor M, Choi H, Davogustto G, Taegtmeyer H, Sung J, Hackam D, Nauen D, Čiháková D. Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Frontiers In Immunology 2019, 10: 634. PMID: 30984196, PMCID: PMC6450181, DOI: 10.3389/fimmu.2019.00634.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsIL-33 productionProgenitor-like featuresLymphoid cellsType 2IL-25 receptorNatural killer cellsSubsets of leukocytesAntigen-specific receptorsILC2 expansionInflammatory ILC2sAdoptive transferCardiac inflammationIL-33Killer cellsInflammatory conditionsMouse modelHealthy humansIschemic conditionsCardiac fibroblastsGATA3 expressionILC2Pathologic environmentHealthy heartIschemia
2017
Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance
Bracamonte-Baran W, Florentin J, Zhou Y, Jankowska-Gan E, Haynes W, Zhong W, Brennan T, Dutta P, Claas F, van Rood J, Burlingham W. Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1099-1104. PMID: 28096390, PMCID: PMC5293109, DOI: 10.1073/pnas.1618364114.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsB7-2 AntigenB7-H1 AntigenCD4-Positive T-LymphocytesChimerismDendritic CellsExtracellular VesiclesFemaleFetomaternal TransfusionH-2 AntigensHistocompatibility Antigen H-2DHistocompatibility Antigens Class IIImmune ToleranceIsoantigensMaleMaternal-Fetal ExchangeMiceMice, Inbred C57BLMice, TransgenicModels, ImmunologicalPregnancyT-Cell Antigen Receptor SpecificityConceptsHost dendritic cellsCD4 T cellsDendritic cellsPD-L1Maternal microchimerismT cellsMyeloid DCsPlasmacytoid DCsMHC alloantigensTransgenic CD4 T cellsMyeloid dendritic cellsPlasmacytoid dendritic cellsExtracellular vesiclesAdoptive transferAntitumor immunityMaternal antigensTransplant toleranceTumor immunityMurine modelSerum EVsPhysiologic linkMHC complexesMiceSerum fractionsMode of action