Maor Sauler, MD
Associate Professor of Medicine (Pulmonary)DownloadHi-Res Photo
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About
Titles
Associate Professor of Medicine (Pulmonary)
Biography
Maor Sauler has been a member of the Pulmonary & Critical Care faculty since 2014. Dr. Sauler specializes in adult critical care including acute lung injury and sepsis. He also sees patients in the outpatient setting with pulmonary diseases such as Chronic Obstructive Pulmonary Disease (COPD). Dr. Sauler is board-certified in internal medicine, pulmonary medicine, and critical care medicine.
Dr. Sauler earned his undergraduate degree from Princeton University and received his MD from Rutgers-New Jersey Medical School. Dr. Sauler then completed both an internship and residency in internal medicine at Yale-New Haven Hospital. He went on to complete fellowship training in pulmonary and critical care medicine at Yale-School of Medicine.
Dr. Sauler investigates mechanisms of lung injury and cytoprotection by integrating findings from high-throughput sequencing technologies with murine and in vitro models of chronic lung disease. Specifically, he is focused on identifying cellular stress responses that change with age or with COPD, and understanding how these mechanisms contribute to disease susceptibility or maintain lung "resilience". By studying the impact of aberrant cellular stress responses on lung injury, inflammation, and repair, Dr. Sauler hopes to identify novel therapeutic targets for patients with COPD.
Appointments
Pulmonary, Critical Care & Sleep Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Yale School of Medicine (2014)
- Resident
- Yale-New Haven Hospital (2009)
- Intern
- Yale-New Haven Hospital (2007)
- MD
- Rutgers New Jersey Medical School (2006)
- BA
- Princeton University (2001)
Research
Overview
Medical Research Interests
Aging; Emphysema; Frail Elderly; Lung Diseases; Lung Injury; Respiratory Distress Syndrome
ORCID
0000-0001-5240-7978
Research at a Glance
Yale Co-Authors
Frequent collaborators of Maor Sauler's published research.
Publications Timeline
A big-picture view of Maor Sauler's research output by year.
Research Interests
Research topics Maor Sauler is interested in exploring.
Naftali Kaminski, MD
Jose Gomez Villalobos, MD, MS
Clemente Britto-Leon, MD
Buqu Hu
Taylor Adams
Xiting Yan, PhD
81Publications
1,732Citations
Aging
Emphysema
Lung Diseases
Respiratory Distress Syndrome
Lung Injury
Publications
Featured Publications
Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease
Sauler M, Leng L, Trentalange M, Haslip M, Shan P, Piecychna M, Zhang Y, Andrews N, Mannam P, Allore H, Fried T, Bucala R, Lee PJ. Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 306: l487-l496. PMID: 24441872, PMCID: PMC3949087, DOI: 10.1152/ajplung.00284.2013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAnimalsApoptosisCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21EmphysemaFemaleHumansIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedPulmonary Disease, Chronic ObstructiveReceptors, ImmunologicSmokeSmokingTobaccoTumor Suppressor Protein p53Young AdultConceptsChronic obstructive pulmonary diseaseMacrophage migration inhibitory factorPathogenesis of COPDDevelopment of COPDMIF receptor CD74Obstructive pulmonary diseasePulmonary diseaseWT miceReceptor CD74Role of MIFMacrophage migration inhibitory factor deficiencyMigration inhibitory factorNormal alveolar structureMo of ageWild-type controlsMIF concentrationsFormer smokersLung volumePlasma concentrationsSpontaneous emphysemaFactor deficiencyCigarette smokePleiotropic cytokineInhibitory factorAlveolar structuresEndothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury
Sauler M, Zhang Y, Min J, Leng L, Shan P, Roberts S, Jorgensen WL, Bucala R, Lee PJ. Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. The FASEB Journal 2015, 29: 1940-1949. PMID: 25609432, PMCID: PMC4415022, DOI: 10.1096/fj.14-260299.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMacrophage migration inhibitory factorLung endothelial cellsMurine lung endothelial cellsLung injuryEndothelial cellsProtective effectExogenous MIFCD74 deficient miceCD74-dependent mannerHours of hyperoxiaMIF receptor CD74Acute lung injuryHyperoxic lung injuryBronchoalveolar lavage proteinMigration inhibitory factorBronchoalveolar proteinMIF deficiencyMedian survivalEndothelial injuryWT miceAcute oxidative stressReceptor CD74Lavage proteinReceptor antagonistReceptor inhibitorsThe DNA repair transcriptome in severe COPD
Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. The DNA repair transcriptome in severe COPD. European Respiratory Journal 2018, 52: 1701994. PMID: 30190272, PMCID: PMC6422831, DOI: 10.1183/13993003.01994-2017.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDNA damage toleranceDNA repairInadequate DNA repairSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseRepair pathwaysGene correlation network analysisIntegrative genomics approachNucleotide excision repair pathwayDNA repair pathwaysGene Set Enrichment AnalysisExcision repair pathwayGlobal transcriptomic profilesDNA repair genesDNA repair responseCorrelation network analysisCOPD severityGenomic approachesLung tissue transcriptomeTranscriptomic differencesTranscriptomic changesTranscriptomic patternsRNA sequencingTissue transcriptomesTranscriptomic profilesMicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease
Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld C, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6: e134218. PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCellular stress responseStress responseHomology-directed DNA repairDNA damage responseProtein BRCA1Damage responseCellular stressDNA repairProtein BimCOPD lung tissueLung epithelial cellsCellular responsesExpression arraysEpithelial cell apoptosisDNA damageChronic obstructive pulmonary diseaseBRCA1 expressionCell apoptosisApoptosisEpithelial cellsCritical mechanismMicroRNAsRegulatorObstructive pulmonary diseaseIncreases SusceptibilityCharacterization of the COPD alveolar niche using single-cell RNA sequencing
Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSingle-cell RNA sequencingRNA sequencingCell-specific mechanismsChronic obstructive pulmonary diseaseAdvanced chronic obstructive pulmonary diseaseTranscriptomic network analysisSingle-cell RNA sequencing profilesCellular stress toleranceAberrant cellular metabolismStress toleranceRNA sequencing profilesTranscriptional evidenceCellular metabolismAlveolar nicheSequencing profilesHuman alveolar epithelial cellsChemokine signalingAlveolar epithelial type II cellsObstructive pulmonary diseaseSitu hybridizationType II cellsEpithelial type II cellsSequencingCOPD pathobiologyHuman lung tissue samplesCell Death in the Lung: The Apoptosis–Necroptosis Axis
Sauler M, Bazan IS, Lee PJ. Cell Death in the Lung: The Apoptosis–Necroptosis Axis. Annual Review Of Physiology 2018, 81: 1-28. PMID: 30485762, PMCID: PMC6598441, DOI: 10.1146/annurev-physiol-020518-114320.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsRegulated cell deathCell deathAutophagic cell deathCell death mechanismsSuperfluous cellsAcute respiratory distress syndromeChronic obstructive pulmonary diseasePulmonary arterial hypertensionIdiopathic pulmonary fibrosisObstructive pulmonary diseaseRespiratory distress syndromeDeath mechanismsCellular mechanismsArterial hypertensionDistress syndromePulmonary diseasePulmonary fibrosisPulmonary disordersMajor mechanismDeathNew modalityPathogenesisNecroptosisMechanismApoptosisA functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity
Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K, Song Y, Michael H, McCormack M, Allore H, Morris A, Crothers K, Bucala R, Lee P, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 316: l400-l405. PMID: 30520689, PMCID: PMC6397351, DOI: 10.1152/ajplung.00439.2018.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMacrophage migration inhibitory factorChronic obstructive pulmonary diseaseMIF -794 CATTAbnormal diffusion capacityCigarette smoke exposureSmoke exposureAssociation of MIFDiffusion capacityMacrophage migration inhibitory factor (MIF) promoter polymorphismsPathogenesis of COPDChronic cigarette smoke exposureMultivariable logistic regression modelModifiable risk factorsObstructive pulmonary diseaseMigration inhibitory factorCross-sectional analysisLogistic regression modelsCommon genetic polymorphismsInnate immune genesAirflow obstructionMIF expressionCOPD severityPulmonary diseaseMIF allelesRisk factors
2024
Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma
Ingram J, McQuade V, Weiss J, Womble J, Ihrie M, Zhao K, Francisco D, Theriot B, May K, Kim H, McCravy M, Sauler M, Lugogo N, Sunday M, Everitt J, Walker J, Tighe R, Kraft M, Que L. Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma. Journal Of Allergy And Clinical Immunology 2024 PMID: 39581293, DOI: 10.1016/j.jaci.2024.10.039.Peer-Reviewed Original ResearchConceptsAirway tissue eosinophiliaBronchoalveolar lavage fluidEotaxin productionHuman airway fibroblastsT2 asthmaAirway fibroblastsIL-13Ra2Tissue eosinophiliaMouse model of chronic allergic airways diseaseEotaxin-1Interleukin-13 receptor alpha 2Chronic allergic airway diseaseNeutralizing antibodies in vitroObesity-associated asthmaLung tissue eosinophiliaConcentration of exhaled nitric oxideFractional concentration of exhaled nitric oxideAllergic airway diseaseEotaxin-1 levelsExhaled nitric oxideBody mass indexAntibodies in vitroHouse dust mite allergen exposureCombined leptinIL13RA2 expressionIdentification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records.
Li H, Huston J, Zielonka J, Kay S, Sauler M, Gomez J. Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2024 PMID: 39423339, DOI: 10.15326/jcopdf.2024.0556.Peer-Reviewed Original ResearchConceptsElectronic health recordsMachine learningAcute exacerbation of COPDAdoption of electronic health recordsHealth recordsMachine learning implementationElectronic health record dataImplementation of MLEHR-derived dataML implementationChronic obstructive pulmonary disease subgroupCOVID-19 cohortSevere acute exacerbation of COPDClinical careExacerbation of COPDAcute exacerbationRetrospective cohort of patientsLearning implementationSeverity of acute exacerbations of COPDMachineRelevant subgroupsRetrospective cohortImplementationCohortCohort of patientsANTAGONISM OF CGAS ABROGATES INFLAMMATORY FIBROTIC RESPONSES IN TRANSLATIONAL MODELS OF SCLERODERMA-ASSOCIATED INTERSTITIAL LUNG DISEASE
YU S, LEE C, HU B, SUN Y, SHAO S, SUN H, GHINCEA A, WOO S, MCGOVERN J, SABER T, GUNES B, KUJAWSKI S, PEREZ S, ODELL W, HINCHCLIFF M, VARGA J, SAULER M, GOMEZ J, RYU C, HERZOG E. ANTAGONISM OF CGAS ABROGATES INFLAMMATORY FIBROTIC RESPONSES IN TRANSLATIONAL MODELS OF SCLERODERMA-ASSOCIATED INTERSTITIAL LUNG DISEASE. CHEST Journal 2024, 166: a3380-a3381. DOI: 10.1016/j.chest.2024.06.2018.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Rising Star
National AwardAmerican Thoracic SocietyDetails05/15/2019United Stateshonor Pepper Center Scholar Award
Yale School of Medicine AwardYale Pepper CenterDetails04/01/2019United Stateshonor K08 Career Development Award
National AwardNational Institute of Health, NHLBIDetails01/01/2017United Stateshonor Young Clinical Scientist Award
National AwardFlight Attendant Medical Research InstituteDetails07/01/2015United Stateshonor Abstract Scholarship Award
National AwardAmerican Thoracic SocietyDetails05/15/2015United States
Clinical Care
Overview
Maor Sauler, MD, specializes in adult pulmonary medicine and critical care, including chronic obstructive pulmonary disease (COPD), sepsis, respiratory distress syndrome and other related diseases. He also sees patients with pulmonary disease in the outpatient setting.
An assistant professor of medicine (pulmonary) at Yale School of Medicine, Dr. Sauler is also interested in understanding the mechanisms of lung disease and integrating “cutting-edge research and technology to bring better diagnostic tests and new therapies to patients,” he says. His research focuses on understanding how aging affects the lungs, and determining how those changes predispose people to lung disease.
Clinical Specialties
Critical Care Medicine; Pulmonology & Sleep Medicine
Fact Sheets
Chronic Obstructive Pulmonary Disease (COPD)
Learn More on Yale Medicine
Board Certifications
Pulmonary Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2013
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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News
- July 09, 2024Source: Everyday Health
Can COPD Be Reversed With Exercise?
- July 01, 2024
Dr. Carolyn L. Rochester received the American Thoracic Society (ATS) Assembly on Pulmonary Rehabilitation Lifetime Achievement Award
- July 24, 2023
Lin Leng, Senior Research Scientist in Medicine (Rheumatology), Retires
- June 08, 2023Source: Yahoo News
Bad Air: Military Across East Coast Deals with Smoke Pollution from Canada
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Locations
The Anlyan Center
Academic Office
300 Cedar Street
New Haven, CT 06519
The Anlyan Center
Lab
300 Cedar Street
New Haven, CT 06519
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.