Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profilesBrief report: the disability of chronic chikungunya arthritis
Amaral JK, Bilsborrow JB, Schoen RT. Brief report: the disability of chronic chikungunya arthritis. Clinical Rheumatology 2019, 38: 2011-2014. PMID: 30963336, PMCID: PMC7400963, DOI: 10.1007/s10067-019-04529-x.Peer-Reviewed Original ResearchConceptsChikungunya feverHealth Assessment Questionnaire Disability IndexPain visual analog scaleChronic chikungunya arthritisHAQ-DI scoresVisual analog scaleSpectrum of painChikungunya arthritisDisability IndexRheumatology clinicRheumatic diseasesAnalog scaleArthritic painDisability levelCCA patientsModerate disabilityPatientsPainEntire groupArthritisMean scoreDisabilityScoresUrgent needMorbidity