Joshua Bilsborrow, MD, MHS
Cards
About
Research
Publications
2019
Chronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common
Amaral JK, Bilsborrow JB, Schoen RT. Chronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common. The American Journal Of Medicine 2019, 133: e91-e97. PMID: 31705850, PMCID: PMC7385732, DOI: 10.1016/j.amjmed.2019.10.005.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisRheumatoid arthritisChikungunya virusAcute febrile illnessAcute illnessFebrile illnessHigh feverInflammatory arthritisMaculopapular rashAcute infectionInfectious causesClinical manifestationsInflammatory processChikungunya feverArthritisFamily TogaviridaeGenus AlphavirusPatientsFeverBetter diagnosisIllnessSignificant proportionRNA virusesVirusMacrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus
Bilsborrow JB, Doherty E, Tilstam PV, Bucala R. Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus. Expert Opinion On Therapeutic Targets 2019, 23: 733-744. PMID: 31414920, PMCID: PMC6800059, DOI: 10.1080/14728222.2019.1656718.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorSystemic lupus erythematosusRheumatoid arthritisMigration inhibitory factorLupus erythematosusMIF inhibitorsMIF inhibitionAutoimmune diseasesRole of MIFInhibitory factorPathogenesis of RARefractory autoimmune diseasesHigh expressionPleiotropic inflammatory cytokineClinical trial dataPrecision medicine approachGlucocorticoid dependenceInflammatory cytokinesAdaptive immunityTherapeutic targetClinical developmentSmall molecule inhibitorsTrial dataTherapeutic potentialErythematosusTranscriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults
Park H, Shin M, Kim M, Bilsborrow J, Mohanty S, Montgomery R, Shaw A, Yoo S, Kang I. Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults. The Journal Of Immunology 2019, 202: 181.22-181.22. DOI: 10.4049/jimmunol.202.supp.181.22.Peer-Reviewed Original ResearchPeripheral blood cellsPeripheral blood mononuclear cellsInfluenza vaccine responsesT cellsEM CD8Memory CD8Vaccine responsesOlder adultsBlood cellsSignature genesEffector memory CD8Blood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Expression profilesSignificant associationTranscription factorsWhole bloodTranscriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profilesBrief report: the disability of chronic chikungunya arthritis
Amaral JK, Bilsborrow JB, Schoen RT. Brief report: the disability of chronic chikungunya arthritis. Clinical Rheumatology 2019, 38: 2011-2014. PMID: 30963336, PMCID: PMC7400963, DOI: 10.1007/s10067-019-04529-x.Peer-Reviewed Original ResearchConceptsChikungunya feverHealth Assessment Questionnaire Disability IndexPain visual analog scaleChronic chikungunya arthritisHAQ-DI scoresVisual analog scaleSpectrum of painChikungunya arthritisDisability IndexRheumatology clinicRheumatic diseasesAnalog scaleArthritic painDisability levelCCA patientsModerate disabilityPatientsPainEntire groupArthritisMean scoreDisabilityScoresUrgent needMorbidity
2018
- Do A, Bilsborrow J, and Lin S. An Acute Exacerbation of Chronic Obstructive Pulmonary Disease Presenting with Neurological Abnormalities. Conn Med. 2018; (82)7: 427-29.Peer-Reviewed Original Research
2009
Enhanced conversion of racemic alpha-arylalanines to (R)-beta-arylalanines by coupled racemase/aminomutase catalysis.
Cox BM, Bilsborrow JB, Walker KD. Enhanced conversion of racemic alpha-arylalanines to (R)-beta-arylalanines by coupled racemase/aminomutase catalysis. The Journal Of Organic Chemistry 2009, 74: 6953-9. PMID: 19711925, DOI: 10.1021/jo9009563.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
Links & Media
News
- June 25, 2024
Yale Rheumatology Program in Global and Community Health Promotes Collaboration and Addresses Disparities
- May 02, 2023
Yale Team Creates Rheumatology Curriculum in Rwanda
- March 08, 2023
Faculty Network Spotlight: NGN
- February 16, 2022
Discoveries & Impact (February 2022)