Samir Gautam, MD/PhD
Cards
About
Research
Publications
Featured Publications
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.Peer-Reviewed Original ResearchDifferences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical featuresNonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19
Cohen A, Glick L, Lee S, Kunitomo Y, Tsang D, Pitafi S, Toro P, Ristic N, Zhang E, Carey G, Datta R, Dela Cruz C, Gautam S. Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19. European Clinical Respiratory Journal 2023, 10: 2174640. PMID: 36815942, PMCID: PMC9930745, DOI: 10.1080/20018525.2023.2174640.Peer-Reviewed Original ResearchSevere COVID-19Bacterial superinfectionBacterial pneumoniaCOVID-19Lower respiratory culturesSuperimposed bacterial pneumoniaUtility of procalcitoninProcalcitonin measurementImmune biomarkersClinical resemblanceRespiratory culturesImmunomodulatory agentsProcalcitoninPatientsBacterial infectionsSuperinfectionCurve analysisSignificant riskCharacteristic curvePneumoniaTime of cultureDiagnosisInfectionBiomarkersSevere respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia
Gautam S, Cohen AJ, Stahl Y, Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.Peer-Reviewed Original ResearchConceptsPure viral infectionBacterial coinfectionViral infectionInfluenza infectionSevere respiratory viral infectionsAbility of procalcitoninRetrospective cohort studyViral respiratory infectionsRespiratory viral infectionsMarker of severityRespiratory viral illnessSevere viral infectionsSpecificity of procalcitoninCharacteristic curve analysisCellular modelHigher procalcitoninProcalcitonin expressionElevated procalcitoninCohort studyViral illnessRespiratory infectionsAntibiotic administrationBacterial pneumoniaSevere diseaseProcalcitoninQuantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia
Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2020, 319: l661-l669. PMID: 32783617, PMCID: PMC7642899, DOI: 10.1152/ajplung.00316.2020.Peer-Reviewed Original ResearchConceptsNeutrophil extracellular trapsAcute respiratory distress syndromeChronic obstructive pulmonary diseaseNeutrophil responseExtracellular trapsDysregulation of neutrophilsObstructive pulmonary diseaseRespiratory distress syndromeNeutrophil effector functionsEx vivo assaysBronchoalveolar neutrophilsSevere asthmaDistress syndromeLung neutrophilsPulmonary diseaseMurine pneumoniaMurine modelEffector functionsNeutrophil researchMouse lungCystic fibrosisMethodologic issuesMurine researchLungArray of diseasesAn Activity‐Based Probe for Studying Crosslinking in Live Bacteria
Gautam S, Kim T, Shoda T, Sen S, Deep D, Luthra R, Ferreira M, Pinho M, Spiegel D. An Activity‐Based Probe for Studying Crosslinking in Live Bacteria. Angewandte Chemie 2015, 127: 10638-10642. DOI: 10.1002/ange.201503869.Peer-Reviewed Original ResearchWall teichoic acidActivity-based probesSingle PBPLive bacteriaAntibiotic targetsCell wallFluorescent mimicTeichoic acidNatural substrateLive cellsEssential processRelative quantitationNatural crosslinksPeptidoglycanBacterial growthSpatiotemporal aspectsBacteriaExperimental toolPBPPeptide mimicsMimicsChemical Probes Reveal an Extraseptal Mode of Cross-Linking in Staphylococcus aureus
Gautam S, Kim T, Spiegel DA. Chemical Probes Reveal an Extraseptal Mode of Cross-Linking in Staphylococcus aureus. Journal Of The American Chemical Society 2015, 137: 7441-7447. PMID: 26035224, DOI: 10.1021/jacs.5b02972.Peer-Reviewed Original ResearchConceptsCross-linking activityPenicillin-binding proteinsCell divisionPeptidoglycan synthesisCell wall biogenesisEnzyme cross-linking activityCell wall synthesisWall biogenesisModel organismsWall synthesisImportant human pathogenCell wallChemical probesEndogenous substratesHuman pathogensSpherical bacteriaPBP4Distinct modesPeripheral wallDivisionBiogenesisS. aureusOrganismsStaphylococcus aureusProteinWall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus
Gautam S, Kim T, Lester E, Deep D, Spiegel DA. Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus. ACS Chemical Biology 2015, 11: 25-30. PMID: 26502318, PMCID: PMC5592732, DOI: 10.1021/acschembio.5b00439.Peer-Reviewed Original ResearchFactor VIII levels and ISTH DIC scores do not distinguish DIC from the coagulopathy of liver disease.
Allen C, Heskel M, Butt A, Tormey C, Pine AB, Lee AI, Gautam S. Factor VIII levels and ISTH DIC scores do not distinguish DIC from the coagulopathy of liver disease. Acta Haematol 2024 PMID: 39004080, DOI: 10.1159/000540239.Peer-Reviewed Original Research
2023
Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome
Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, DOI: 10.1159/000530153.Peer-Reviewed Original ResearchConceptsAML/myelodysplastic syndromeAcute myeloid leukemiaInternational normalized ratioAntibacterial prophylaxisMyelodysplastic syndromeProphylactic antibacterialsCoagulation profileAcute myeloid leukemia/myelodysplastic syndromeDiagnosis of AMLHigher international normalized ratioLeukemia/myelodysplastic syndromePartial thromboplastin time prolongationYale-New Haven HospitalYale-New HavenRetrospective cohort studyAbnormal coagulation profileGroup of patientsTime of admissionHigh rateIndividual patient encountersInstitutional review boardAntibacterial exposureRelevant bleedingAdult patientsCohort study
Academic Achievements and Community Involvement
Teaching & Mentoring
Clinical Care
Overview
Clinical Specialties
Pulmonary Critical Care ; Asthma
Board Certifications
Pulmonary Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2022
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2020
Links & Media
News
- April 13, 2023
Discoveries & Impact (April 2023)
- June 23, 2021
Meet Yale-PCCSM's Fellows
- September 17, 2020
Discoveries & Impact (September 2020)