Featured Publications
Development and validation of a prediction model for persistent functional impairment among older ICU survivors
Ferrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Vander Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.Peer-Reviewed Original ResearchConceptsPersistent functional impairmentICU hospitalizationFunctional impairmentValidation cohortICU admissionDevelopment cohortOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsOlder ICU survivorsMonths of dischargeHigh-risk survivorsCommunity-living participantsGood calibrationHospital lengthICU survivorsCritical illnessMedian agePrior hospitalizationFunctional recoveryNational HealthProbable dementiaHospitalizationHigh riskDepressive symptomsAssociation Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study.
Jain S, Murphy TE, O'Leary JR, Leo-Summers L, Ferrante LE. Association Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study. Annals Of Internal Medicine 2022, 175: 644-655. PMID: 35254879, PMCID: PMC9316386, DOI: 10.7326/m21-3086.Peer-Reviewed Original ResearchConceptsICU hospitalizationIntensive care unitMental healthCohort studyCritical illnessDual eligibilityOlder adultsProbable dementiaSocioeconomic disadvantageOlder personsGreater riskCommunity-dwelling older adultsLongitudinal cohort studySymptoms of depressionAging Trends StudyOutcome of functionMental health outcomesClinical characteristicsLow-income seniorsCare unitNational HealthRetrospective analysisHospitalizationOlder survivorsDaily livingAssociation of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness
Falvey JR, Cohen AB, O’Leary J, Leo-Summers L, Murphy TE, Ferrante LE. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Internal Medicine 2021, 181: 1433-1439. PMID: 34491282, PMCID: PMC8424527, DOI: 10.1001/jamainternmed.2021.5022.Peer-Reviewed Original ResearchConceptsCritical illnessICU hospitalizationSocial isolation scoresOlder adultsICU admissionCohort studyPrimary outcomeDisability burdenSocial isolationCommunity-dwelling older adultsGreater disability burdenIsolation scoresPost-ICU disabilityObservational cohort studyAging Trends StudyICU stayMortality cohortHospital dischargeSecondary outcomesHospital admissionMedian ageIllness severityAdverse outcomesNational HealthHospitalization dataNeighborhood Socioeconomic Disadvantage and Disability After Critical Illness*
Falvey JR, Murphy TE, Leo-Summers L, Gill TM, Ferrante LE. Neighborhood Socioeconomic Disadvantage and Disability After Critical Illness*. Critical Care Medicine 2021, 50: 733-741. PMID: 34636807, PMCID: PMC9001742, DOI: 10.1097/ccm.0000000000005364.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic disadvantageDisability burdenHigher disability burdenCritical illnessSocioeconomic disadvantageOlder adultsCritical illness survivorsLongitudinal cohort studyArea Deprivation IndexDisadvantaged neighborhoodsNon-Hispanic whitesDifferent functional tasksICU admissionICU dischargeICU survivorsCohort studyDischarge destinationHospital dischargeFunctional recoveryNeighborhood disadvantageAdjusted modelCare servicesSecondary analysisSecondary objectiveIllnessAGS Position Statement: Resource Allocation Strategies and Age‐Related Considerations in the COVID‐19 Era and Beyond
Farrell TW, Ferrante LE, Brown T, Francis L, Widera E, Rhodes R, Rosen T, Hwang U, Witt LJ, Thothala N, Liu SW, Vitale CA, Braun UK, Stephens C, Saliba D. AGS Position Statement: Resource Allocation Strategies and Age‐Related Considerations in the COVID‐19 Era and Beyond. Journal Of The American Geriatrics Society 2020, 68: 1136-1142. PMID: 32374440, PMCID: PMC7267615, DOI: 10.1111/jgs.16537.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Geriatrics SocietyOlder adultsAppropriate advance care planningShort-term outcomesRelevant clinical factorsCoronavirus disease 2019Advance care planningPotential short-term outcomeClinical factorsSevere illnessAdvanced ageDisease 2019Care planningMortality riskGeriatrics SocietySocial determinantsHealthcare professionalsHealth systemOlder peopleInterprofessional expertsEthics CommitteeCOVID-19 eraLife expectancyAgeCOVID-19Pre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults
Ferrante LE, Murphy TE, Gahbauer EA, Leo-Summers LS, Pisani MA, Gill TM. Pre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults. Annals Of The American Thoracic Society 2018, 15: 622-629. PMID: 29446993, PMCID: PMC5949607, DOI: 10.1513/annalsats.201709-702oc.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionNew nursing home admissionsNursing home admissionCare unit admissionHome admissionCritical illnessUnit admissionModerate impairmentCognitive statusCognitive impairmentOlder adultsMinimal impairmentMultivariable analysisIntensive care unit stayMini-Mental State ExaminationProspective cohort studyIll Older AdultsModerate cognitive impairmentUnit stayCohort studySecondary outcomesSubsequent disabilityPrimary outcomeMean agePrognostic informationFactors Associated with Functional Recovery among Older Intensive Care Unit Survivors
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.Peer-Reviewed Original ResearchConceptsHigher body mass indexOlder ICU survivorsIntensive care unitBody mass indexFunctional recoveryICU survivorsICU admissionMass indexOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsPoor functional recoveryCritical illnessIndependent predictorsCare unitMultivariable analysisFunctional outcomePremorbid functionPotential predictorsVision impairmentAdmissionSurvivorsAnalytic sampleFunctional activityMonthsIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stayFeasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illness
2024
Association Between Restricting Symptoms and Disability After Critical Illness Among Older Adults.
Jain S, Han L, Gahbauer E, Leo-Summers L, Feder S, Ferrante L, Gill T. Association Between Restricting Symptoms and Disability After Critical Illness Among Older Adults. Critical Care Medicine 2024, 52: 1816-1827. PMID: 39298623, DOI: 10.1097/ccm.0000000000006427.Peer-Reviewed Original ResearchActivities of daily livingAssociated with increased disabilityDaily livingOlder adultsRestricting symptomsInstrumental activities of daily livingCommunity-living older adultsICU hospitalizationMultivariable Poisson regression modelsCommunity-living adultsOlder ICU survivorsAge of participantsPoisson regression modelsSurvive critical illnessCritical illnessQuality of lifeInstrumental activitiesICU survivorsProspective longitudinal studyLength of stayPost-ICUIncreased disabilityMonthly interviewsICU length of stayPre-ICUExploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials
Perrella A, Geen O, Ahuja M, Scott S, Kaushik R, Ferrante L, Brummel N, Muscedere J, Rochwerg B. Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Critical Care Medicine 2024, 52: e463-e472. PMID: 38661459, DOI: 10.1097/ccm.0000000000006315.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCritical care interventionsRandomized controlled trialsCare interventionsOlder adultsCluster randomized controlled trialStatistically significant effect modificationSubgroup effectsIll older adultsControlled trialsCritically ill older adultsSystematic review of randomized controlled trialsSignificant effect modificationReview of randomized controlled trialsCritical care randomized controlled trialsCritical care journalsStatistically significant subgroup effectsIndividual patient preferencesSubgroups of ageIntervention effectsMultimorbidityEffect modificationFrailty subgroupsICU interventionsStudy characteristicsGeneral medicine
2023
Changes in Restricting Symptoms after Critical Illness among Community-Living Older Adults.
Jain S, Han L, Gahbauer E, Leo-Summers L, Feder S, Ferrante L, Gill T. Changes in Restricting Symptoms after Critical Illness among Community-Living Older Adults. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 1206-1215. PMID: 37769149, PMCID: PMC10868351, DOI: 10.1164/rccm.202304-0693oc.Peer-Reviewed Original ResearchConceptsNeighborhood-level socioeconomic disadvantageCritical illnessIntensive care unitHospital dischargeCommunity-living older adultsOlder adultsOlder ICU survivorsPost-ICU careSocioeconomic disadvantageProspective longitudinal studyQuality of lifeICU admissionICU survivorsCare unitFunctional recoverySymptom managementMultiple symptomsThird monthThree monthsSymptomsIllnessRestricted activityVulnerable subgroupsFirst monthMonths
2022
Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort
Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Ferrante L. Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort. Journal Of The American Geriatrics Society 2022, 71: 832-844. PMID: 36544250, PMCID: PMC9877652, DOI: 10.1111/jgs.18146.Peer-Reviewed Original ResearchConceptsPatient-centered outcomesCOVID-19 hospitalizationCognitive impairmentPhysical functionOlder COVID-19 survivorsCOVID-19-related symptomsCOVID-19Older adultsIntensive care unitCOVID-19 survivorsPersistent cognitive impairmentSix-month followMost older adultsThird of participantsElectronic health recordsStepdown unitAcute illnessBurdensome symptomsCare unitSupplemental oxygenMedian lengthProspective studyMean ageBlack raceBaseline interviewClin‐STAR corner: Recent practice‐changing studies at the interface of pulmonary and critical care medicine and geriatrics
Jain S, Witt L, Ferrante L. Clin‐STAR corner: Recent practice‐changing studies at the interface of pulmonary and critical care medicine and geriatrics. Journal Of The American Geriatrics Society 2022, 71: 705-710. PMID: 36536494, PMCID: PMC10023292, DOI: 10.1111/jgs.18196.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCritical care medicineCritical illnessPulmonary diseaseLung diseaseCare medicineRecent practice-changing clinical trialsChronic obstructive pulmonary diseaseOlder adultsAcute respiratory failurePractice-changing clinical trialsChronic lung diseaseChronic pulmonary diseaseObstructive pulmonary diseaseInterstitial lung diseasePractice-changing studiesGreater side effectsRespiratory failureAdverse outcomesClinical trialsObservational studySide effectsDiseaseIllnessAdultsMedicineLong-term recovery after critical illness in older adults
Kaushik R, Ferrante LE. Long-term recovery after critical illness in older adults. Current Opinion In Critical Care 2022, 28: 572-580. PMID: 35950731, PMCID: PMC9458622, DOI: 10.1097/mcc.0000000000000981.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOlder ICU patientsPost-ICU recoveryCritical illnessGeriatric syndromesLong-term recoveryOlder adultsICU patientsRisk factorsIncidence of frailtyOlder ICU survivorsTransitional care programLong-term outcomesContinuum of careSocial isolationRecent epidemiologic workSocial risk factorsICU survivorsRecent literature pertainingUnique needsRecent longitudinal studiesNew disabilityWorse outcomesFunctional declineCare programSyndromeTrends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015
Cobert J, Jeon SY, Boscardin J, Chapman AC, Ferrante LE, Lee S, Smith AK. Trends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015. CHEST Journal 2022, 161: 1555-1565. PMID: 35026299, PMCID: PMC9248079, DOI: 10.1016/j.chest.2021.12.658.Peer-Reviewed Original ResearchConceptsICU admissionPre-existing disabilityGeriatric conditionsOlder adultsSelf-reported chronic diseasesPatients 65 yearsRate of dementiaICU patientsAdverse outcomesICU settingChronic diseasesAdjusted proportionDaily livingMultimorbidityICUAdmissionGeriatric principlesFrailtyDementiaUS ICUsFunctional measuresStudy designDisabilityAdultsTime trends
2020
Embedding and Sustaining a Focus on Function in Specialty Research and Care
Callahan KE, Boustani M, Ferrante L, Forman DE, Gurwitz J, High KP, McFarland F, Robinson T, Studenski S, Yang M, Schmader KE. Embedding and Sustaining a Focus on Function in Specialty Research and Care. Journal Of The American Geriatrics Society 2020, 69: 225-233. PMID: 33064303, PMCID: PMC7871732, DOI: 10.1111/jgs.16860.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFunctional assessmentOlder adultsComprehensive geriatric assessmentGeriatric assessmentSpecialty researchJohn A. Hartford FoundationSurgical careFunctional gainsFunctional limitationsClinical practiceSurgical therapeuticsHealth systemCareNational InstituteTeam science approachDaily activitiesHartford FoundationFrontline staffAdultsAssessmentGeriatriciansClinicians
2019
Care of the Critically Ill Older Adult
Gao C, Ferrante L. Care of the Critically Ill Older Adult. Annual Update In Intensive Care And Emergency Medicine 2019, 611-623. DOI: 10.1007/978-3-030-06067-1_47.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsICU admissionIntensive care unit populationOlder adultsIll Older AdultsYears of ageICU complicationsOlder patientsAdmission ratesUnit populationGreater riskPopulation agesPatientsDay careVulnerable populationsUnique populationAdmissionHigh rateCareFuture studiesAdultsAgePopulationComorbiditiesDeliriumComplications
2015
Understanding and Reducing Disability in Older Adults Following Critical Illness*
Brummel NE, Balas MC, Morandi A, Ferrante LE, Gill TM, Ely EW. Understanding and Reducing Disability in Older Adults Following Critical Illness*. Critical Care Medicine 2015, 43: 1265-1275. PMID: 25756418, PMCID: PMC4640688, DOI: 10.1097/ccm.0000000000000924.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCritical illnessOlder adultsDisability outcomesDaily livingAcute critical illnessCognitive outcomesModifiable risk factorsGeriatric care modelsLong-term disabilitySevere cognitive impairmentWeb of ScienceIll patientsGeriatric conditionsPoor outcomeHeavy sedationIncident dementiaICU practiceRisk factorsEpidemiologic dataInstrumental activitiesCare modelCognitive declineCognitive impairmentIllnessAdditional citations