2023
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.Peer-Reviewed Original ResearchDifferences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical featuresMortality Differences Among Patients With Airway Disease Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.Peer-Reviewed Original ResearchActivation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma
Chupp G, Liu Q, Adams T, Schupp J, Wilson G, Grant N, Gomez J, Cohn L, Kaminski N, Akuthota P, Weiss S, Glass K, Bleecker E, Meyers D, Tantisira K, Yan X. Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma. 2023, a5689-a5689. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5689.Peer-Reviewed Original Research
2022
The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma
Sher L, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Soler X, Khodzhayev A, Jacob-Nara J, Deniz Y, Rowe P, Nag A, Zhang Y. The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma. Annals Of Allergy Asthma & Immunology 2022, 130: 298-304. PMID: 36509407, DOI: 10.1016/j.anai.2022.12.002.Peer-Reviewed Original ResearchConceptsPlacebo-treated patientsSevere asthmaActivity limitationsDose reductionAQLQ scoresDupilumab groupWeek 24Open-label extensionProportion of patientsType 2 inflammationHuman monoclonal antibodyQuality of lifeOral corticosteroidsOCS useInterleukin-4Long-term effectsAsthmaPatientsSymptomsMonoclonal antibodiesSleepReceptor componentsDupilumabDyspneaWeeksEffect of dupilumab on improving physical activity in patients with severe asthma
Sher L, Passalacqua G, Cohn L, Daizadeh N, Pandit-Abid N, Ortiz B, Atenhan A, Thakur M, Khan A, Zhang Y. Effect of dupilumab on improving physical activity in patients with severe asthma. Pneumologie 2022, 76: s35-s35. DOI: 10.1055/s-0042-1747768.Peer-Reviewed Original ResearchPOSB359 Effect of Dupilumab on Physical and Work-Related Activity in Patients with Moderate-to-Severe Asthma: Liberty Asthma QUEST
Sher L, Taillé C, Cohn L, Quirce S, Daizadeh N, Pandit-Abid N, Ortiz B, Nag A, Zhang Y. POSB359 Effect of Dupilumab on Physical and Work-Related Activity in Patients with Moderate-to-Severe Asthma: Liberty Asthma QUEST. Value In Health 2022, 25: s230. DOI: 10.1016/j.jval.2021.11.1126.Peer-Reviewed Original Research
2021
REAL-WORLD EFFECTIVENESS OF DUPILUMAB ON PATIENT-REPORTED OUTCOMES AND SYMPTOMS IN ASTHMA: 3-MONTH FOLLOW-UP DATA FROM RESPIRE, AN OBSERVATIONAL STUDY WITH PATIENTS RECRUITED FROM A US DUPILUMAB PATIENT SUPPORT PROGRAM
Cohn L, Zhang Y, Wang J, Chen C, Ortiz B, Djandji M, Zhang S, Yang M, Zeiger R. REAL-WORLD EFFECTIVENESS OF DUPILUMAB ON PATIENT-REPORTED OUTCOMES AND SYMPTOMS IN ASTHMA: 3-MONTH FOLLOW-UP DATA FROM RESPIRE, AN OBSERVATIONAL STUDY WITH PATIENTS RECRUITED FROM A US DUPILUMAB PATIENT SUPPORT PROGRAM. CHEST Journal 2021, 160: a29-a30. DOI: 10.1016/j.chest.2021.07.075.Peer-Reviewed Original ResearchEffect of dupilumab on patient-reported sleep outcomes in patients with severe asthma
Sher L, Passalacqua G, Taillé C, Cohn L, Quirce S, Daizadeh N, Pandit-Abid N, Ortiz B, Khan A, Zhang Y. Effect of dupilumab on patient-reported sleep outcomes in patients with severe asthma. 2021, pa3733. DOI: 10.1183/13993003.congress-2021.pa3733.Peer-Reviewed Original ResearchEffect of dupilumab on improving physical activity in patients with severe asthma
Sher L, Quirce S, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Ortiz B, Khan A, Zhang Y. Effect of dupilumab on improving physical activity in patients with severe asthma. 2021, pa880. DOI: 10.1183/13993003.congress-2021.pa880.Peer-Reviewed Original Research
2020
DUPILUMAB IMPROVES PATIENT-REPORTED BREATHING IN ORAL CORTICOSTEROID-DEPENDENT SEVERE ASTHMA
Sher L, Wolfe R, Quirce S, Cohn L, Passalacqua G, Paggiaro P, Taillé C, Daizadeh N, Ortiz B, Pandit-Abid N, Khan A, Kamat S. DUPILUMAB IMPROVES PATIENT-REPORTED BREATHING IN ORAL CORTICOSTEROID-DEPENDENT SEVERE ASTHMA. CHEST Journal 2020, 158: a1752-a1754. DOI: 10.1016/j.chest.2020.08.1538.Peer-Reviewed Original Research
2019
MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma
Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.Peer-Reviewed Original ResearchCell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma
Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.Peer-Reviewed Original Research
2018
BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation
Khanal S, Niu N, Huleihel L, Herazo-Maya J, Kaminski N, Cohn L, Britto C. BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation. 2018, pa4254. DOI: 10.1183/13993003.congress-2018.pa4254.Peer-Reviewed Original Research
2016
MAPKAP kinase 2(MK2) expression is associated with severe asthma
Chupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma. 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.Peer-Reviewed Original ResearchProinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups
Gueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups. 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.Peer-Reviewed Original Research
2013
VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis
Takyar S, Vasavada H, Zhang J, Ahangari F, Niu N, Liu Q, Lee C, Cohn L, Elias J. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis. Journal Of Cell Biology 2013, 202: 2027oia101. DOI: 10.1083/jcb.2027oia101.Peer-Reviewed Original Research
2012
Characterization Of The Poor Emotional Function Phenotype In Asthma
Scatena R, Holm C, He S, Wright P, Sessa W, Cohn L, Gomez-Villalobos J, Mitchell A, Chupp G. Characterization Of The Poor Emotional Function Phenotype In Asthma. 2012, a3967-a3967. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3967.Peer-Reviewed Original ResearchSPLUNC1 Is Inhibited In Common Respiratory Infections By Toll-Like Receptor (TLR) Activation And Inflammatory Cytokines
Britto C, Liu Q, Dela Cruz C, Cohn L. SPLUNC1 Is Inhibited In Common Respiratory Infections By Toll-Like Receptor (TLR) Activation And Inflammatory Cytokines. 2012, a1065-a1065. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1065.Peer-Reviewed Original Research
2011
IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease
Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease. The Journal Of Immunology 2011, 187: 3815-3820. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.Peer-Reviewed Original ResearchConceptsAirway epitheliumAllergic airway inflammationAllergic airway diseaseTh2 cell activationGoal of therapyProduction of IFNAdministration of medicationsSystemic side effectsAirway mucosal surfaceAirway epithelial cellsSites of inflammationIFN-γ actionAirway inflammationAirway obstructionPersistent asthmaRefractory asthmaAirway diseaseIFN-γRTh1 cellsPathological responseSystemic pathologyEffector functionsSide effectsBone marrowAsthma