2014
Systemic Manifestations and Comorbidities of Chronic Obstructive Pulmonary Disease
Most J, Possick J, Rochester C. Systemic Manifestations and Comorbidities of Chronic Obstructive Pulmonary Disease. Clinical Pulmonary Medicine 2014, 21: 155-166. DOI: 10.1097/cpm.0000000000000044.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSystemic inflammationPulmonary diseaseMore health care resourcesGastroesophageal reflux diseaseObstructive sleep apneaSkeletal muscle dysfunctionHealth care resourcesQuality of lifeCOPD patientsReflux diseaseRenal insufficiencyCommon comorbiditiesSystemic manifestationsMuscle dysfunctionSleep apneaFunctional statusLung cancerChronic infectionChronic diseasesCardiovascular diseaseComorbiditiesHigh riskCare resources
2008
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAdolescentAdultAgedAged, 80 and overAsthmaBiomarkersBronchial HyperreactivityCase-Control StudiesChildChitinase-3-Like Protein 1FemaleFounder EffectGenetic Predisposition to DiseaseGenotypeGlycoproteinsHumansLectinsMaleMiddle AgedPhenotypePolymorphism, Single NucleotidePulmonary VentilationConceptsSerum YKL-40 levelsYKL-40 levelsLung functionYears of ageBronchial hyperresponsivenessPulmonary functionSingle nucleotide polymorphismsYKL-40Elevated serum YKL-40 levelsBirth cohortChitinase-like protein YKL-40Presence of asthmaProtein YKL-40Risk of asthmaPromoter single nucleotide polymorphismsEuropean descentSubepithelial basement membraneCase-control populationCase patientsAsthma statusAsthmaHigh riskChitinase 3Same single nucleotide polymorphismCHI3L1