2007
Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis
Kang HR, Lee CG, Homer RJ, Elias JA. Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis. Journal Of Experimental Medicine 2007, 204: 1083-1093. PMID: 17485510, PMCID: PMC2118575, DOI: 10.1084/jem.20061273.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntigens, CDApoptosisCollagenDNA DamageImmunoblottingImmunohistochemistryIn Situ HybridizationIn Situ Nick-End LabelingIntegrin beta1MiceMice, TransgenicNerve Tissue ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPulmonary AlveoliPulmonary FibrosisReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSemaphorinsTransforming Growth Factor beta1ConceptsProtein kinase BSEMA 7APKB/Akt inhibitionAkt-dependent pathwayCritical roleSemaphorin 7ACCN proteinsFibroblast growth factor-2Kinase BCritical regulatorApoptosis regulatorMatrix proteinsGrowth factor 2Akt inhibitionBeta1 integrinReceptor componentsTissue remodelingFactor 2Fibrotic stimuliSmad 2/3Myofibroblast hyperplasiaGrowth factorRegulatorCentral roleProtein
2003
Transgenic modeling of interleukin-13 in the lung.
Elias J, Zheng T, Lee C, Homer R, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic modeling of interleukin-13 in the lung. CHEST Journal 2003, 123: 339s-45s. PMID: 12628967, DOI: 10.1378/chest.123.3_suppl.339s-a.Peer-Reviewed Original ResearchConceptsIL-13Transforming growth factor-beta(1Vascular endothelial growth factorChemokine receptor 2Endothelial growth factorRegulation of inflammationOverexpressing transgenic miceMurine airwaysAdenosine accumulationAsthma pathogenesisReceptor 2Interleukin-13Transgenic miceIL-11Growth factorGenetic targetsTransgenic modelsLungPhenotypic alterationsRegulate aspectsAdenosine