2015
Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*
Ahasic AM, Tejera P, Wei Y, Su L, Mantzoros CS, Bajwa EK, Thompson BT, Christiani DC. Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*. Critical Care Medicine 2015, 43: 2651-2659. PMID: 26427594, PMCID: PMC4651824, DOI: 10.1097/ccm.0000000000001314.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAcute DiseaseAge FactorsAgedAged, 80 and overAPACHEBody Mass IndexChronic DiseaseCritical IllnessFemaleGenotypeHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IIntensive Care UnitsLinear ModelsMaleMiddle AgedPhenotypePolymorphism, GeneticProspective StudiesRisk FactorsSex FactorsConceptsInsulin-like growth factor-binding protein-3Insulin-like growth factor-1Acute respiratory distress syndromeGrowth factor-1Respiratory distress syndromeInsulin-like growth factor-binding protein-3 levelsProtein-3 levelsCritical illnessBody mass indexDistress syndromeProtein 3Acute PhysiologyMass indexFactor 1Chronic Health Evaluation III scoreInsulin-like growth factor-1 levelsChronic Health Evaluation IIISepsis/septic shockGrowth factor-1 levelsTotal insulin-like growth factor-1Insulin-like growth factorAcute critical illnessAcute hepatic dysfunctionReceipt of corticosteroidsLarge prospective studiesPersonalized Critical Care Medicine: How Far Away Are We?
Ahasic AM, Christiani DC. Personalized Critical Care Medicine: How Far Away Are We? Seminars In Respiratory And Critical Care Medicine 2015, 36: 809-822. PMID: 26595041, DOI: 10.1055/s-0035-1564852.Peer-Reviewed Original ResearchConceptsCritical illnessClinical trialsAcute respiratory distress syndromeRespiratory distress syndromeIntensive care unitCritical care arenaDirect patient careUnique risk factorsMulti-biomarker panelAccurate diagnostic classificationMajor clinical applicationsPrecise medical careDistress syndromeCare unitPoor outcomeRisk factorsTreatment decisionsIndividual patientsClinical careClinical utilitySuch biomarkersMedical carePatient careClinical useIllness
2014
Functional status after critical illness: agreement between patient and proxy assessments
Ahasic AM, Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Functional status after critical illness: agreement between patient and proxy assessments. Age And Ageing 2014, 44: 506-510. PMID: 25324334, PMCID: PMC4411220, DOI: 10.1093/ageing/afu163.Peer-Reviewed Original ResearchConceptsMonths post-ICU dischargePost-ICU dischargeFunctional statusCritical illnessInter-observer agreementICU admissionOlder patientsExact testIntensive care unit admissionProxy assessmentsPremorbid functional statusCare unit admissionBaseline functional statusCurrent functional statusMcNemar's exact testUnit admissionICU dischargeMedical ICUNeuropsychological morbidityInstrumental ADLCognitive dysfunctionDaily livingPatientsCognitive impairmentParent cohortAdiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality
Ahasic AM, Zhao Y, Su L, Sheu CC, Thompson BT, Christiani DC. Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality. PLOS ONE 2014, 9: e89170. PMID: 24586568, PMCID: PMC3929660, DOI: 10.1371/journal.pone.0089170.Peer-Reviewed Original ResearchConceptsARDS casesInsulin resistanceSingle nucleotide polymorphismsCase statusAcute respiratory distress syndrome (ARDS) riskFunctional polymorphismsAnti-inflammatory adipokineAcute respiratory failureDevelopment of ARDSAdiponectin gene polymorphismsMultiple comparisonsAdipokine levelsCause mortalityRespiratory failureAdiponectin levelsCritical illnessConsecutive patientsMultivariable analysisRisk factorsSyndrome riskCardiovascular diseaseAdipose tissueGene polymorphismsARDSMortality