2011
Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
Wisnewski AV, Xu L, Robinson E, Liu J, Redlich CA, Herrick CA. Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses. Journal Of Occupational Medicine And Toxicology 2011, 6: 6. PMID: 21414210, PMCID: PMC3068988, DOI: 10.1186/1745-6673-6-6.Peer-Reviewed Original ResearchRespiratory tract inflammationImmune sensitizationSkin exposureMDI conjugationBronchoalveolar lavageInflammatory responseRespiratory tract exposureAirway inflammatory responseAcetone/olive oilSubsequent immune responseSpecific antibody productionDisease prevention effortsAlbumin conjugatesOccupational asthmaSerum levelsMDI exposureAsthma pathogenesisSerum IgGIntranasal deliveryImmune responseImmune sensitivityMurine modelPathogenic mechanismsInflammationAntibody production
2010
Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?
Wisnewski AV, Jones M. Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease? Clinical & Experimental Allergy 2010, 40: 1155-1162. PMID: 20545707, PMCID: PMC3121887, DOI: 10.1111/j.1365-2222.2010.03550.x.Peer-Reviewed Original ResearchConceptsAllergen-specific IgEOccupational asthmaIsocyanate asthmaPro/Con DebateScreening/surveillanceCause of asthmaIgE-mediated diseasesHypersensitive individualsLow molecular weight chemicalsEnvironmental AsthmaAllergic asthmaBronchial hyperreactivityHypersensitivity disordersCommon causeAsthmaPathogenic mechanismsIgEChronic exposureCon debateImportant mediatorDiagnostic testsWeight chemicalsDiseaseHypersensitivityPrevention