Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsNatalia Kunst, PhD
Assistant Professor AdjunctAbout
Research
Publications
2026
Cost-Effectiveness Analysis of 177Lu-PSMA-617 Versus Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer from a U.S. Health Care Perspective.
Gogebakan K, Kunst N, Ghodsi A, Owens L, Iravani A, Etzioni R. Cost-Effectiveness Analysis of 177Lu-PSMA-617 Versus Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer from a U.S. Health Care Perspective. Journal Of Nuclear Medicine 2026, jnumed.125.271825. PMID: 41856667, DOI: 10.2967/jnumed.125.271825.Peer-Reviewed Original ResearchLu-PSMA-617Progression-free survivalOverall survivalWTP thresholdQuality-adjusted life yearsBase case analysisOS HRTheraP trialMetastatic castration-resistant prostate cancerPatients treated with cabazitaxelCastration-resistant prostate cancerHealth care perspectiveConclusion:Results:Severe adverse eventsCost-effectiveness analysisIncremental cost-effectiveness ratioLikelihood of cost-effectivenessWTPMonetary benefitsCost-effectiveness ratioLow likelihoodCost-effectiveness resultsHealth care utilization ratesPatient-reported outcomesTen Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group
Mandrik O, Thomas C, Bessey A, Brennan A, Carvalho A, Castilla-Rodríguez I, Doroshenko O, Hill H, Kunst N, Nagy B, Payne K, Pollard D, Ramsey S, Roitberg F, Shinkins B, Smitht R, Howard T, Whyte S. Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group. PharmacoEconomics 2026, 1-16. PMID: 41760865, DOI: 10.1007/s40273-026-01602-7.Peer-Reviewed Original ResearchHealth economic modelScreening interventionsCost-effectiveness of screening interventionsModel cost-effectivenessEffects of screening interventionsCost-effectiveness of screening programmesEffectiveness of screening programmesCost-effectiveness of screeningAbsence of screeningEffectiveness of screeningCost-effectiveFollow-up diagnosticsScreening programmeScreening recallStakeholder meetingsLack of knowledgeInternational expert groupInternal stakeholder groupsHealth economistsEconomic modelHealthDraft recommendationsHealth statesHealthy peopleInterventionA Taxonomy for Assessing Real-World Targeted Cancer Therapy Options in the Context of Broad Genomic Profiling.
Wang X, Long J, Rothen J, Huang S, Soulos P, Goldberg S, Robinson T, Ma S, Mamtani R, Presley C, Wang S, Kunst N, Gross C, Dinan M. A Taxonomy for Assessing Real-World Targeted Cancer Therapy Options in the Context of Broad Genomic Profiling. Journal Of The National Comprehensive Cancer Network 2026, 24 PMID: 41698347, DOI: 10.6004/jnccn.2025.7131.Peer-Reviewed Original ResearchThis study introduces Y-MATRIX, a taxonomy classifying genomic profiling results by clinical actionability, showing increased actionable findings in advanced lung cancer from 2017 to 2023.Adoption and Regional Variation of Prostate-Specific Membrane Antigen Positron Emission Tomography in the United States.
Leapman M, Long J, Westvold S, Rabil M, Sprenkle P, Kim I, Spilberg G, Saperstein L, Fallah J, Suzman D, Lerro C, Xu J, Rivera D, Kluetz P, Karnes R, Dinan M, Mitchell A, Kunst N, Wang S, Ma X, Gross C. Adoption and Regional Variation of Prostate-Specific Membrane Antigen Positron Emission Tomography in the United States. JCO Oncology Practice 2026, op2500617. PMID: 41632928, DOI: 10.1200/op-25-00617.Peer-Reviewed Original ResearchProstate-specific membrane antigen positron emission tomographyPSMA-PETProstate cancerPositron emission tomographyPET imagingNational utilization patternsIncident prostate cancer casesLong-term clinical benefitPSMA PET imagingEmission tomographyProstate cancer casesEvidence of diagnostic accuracyCross-sectional studyClinical benefitCancer casesEligible patientsDiagnostic accuracyProstateInsurance beneficiariesCancerClinical practiceHealth care characteristicsProportion of individualsAdministrative claimsTomographyEffectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes
Andersen L, Holmberg M, Krijkamp E, Stankovic N, Meilandt C, Vallentin M, Høybye M, Folke F, Kunst N, Dijk S, Granfeldt A, Caulley L. Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes. JAMA Internal Medicine 2026, 186: 37-43. PMID: 41137600, PMCID: PMC12554008, DOI: 10.1001/jamainternmed.2025.6123.Peer-Reviewed Original ResearchAutomated external defibrillator applicationAutomated external defibrillatorShockable rhythmCardiac arrestExternal defibrillatorsAutomated external defibrillator useEffect of automated external defibrillatorsPrivate homesHospital dischargeCardiac Arrest RegistryCardiac arrest incidenceDifference-in-differences analysisCost-effectiveIncremental cost-effectiveness ratioGeneral purchasersCost-effectiveness thresholdArrest incidenceMain OutcomesCost-effectiveness ratioNonshockable rhythmsCohort studyDecision-analytic modelDifference-in-differences approachHomeSaving lives
2025
Cost‐effectiveness of low‐dose CT lung cancer screening among individuals that have ever smoked in Norway: A model‐based analysis using NELSON trial criteria and outcomes
Wu Y, Kunst N, Győrbiró D, Kristiansen I, Strand T, Nguyen O, Fotopoulos I, Røe O, Ashraf H, Burger E. Cost‐effectiveness of low‐dose CT lung cancer screening among individuals that have ever smoked in Norway: A model‐based analysis using NELSON trial criteria and outcomes. International Journal Of Cancer 2025, 158: 2452-2465. PMID: 41414902, DOI: 10.1002/ijc.70270.Peer-Reviewed Original ResearchLow-dose computed tomographyQuality-adjusted life yearsLung cancer screeningIncremental cost-effectiveness ratioLDCT screeningCancer screeningCost-effectiveness of LDCT screeningLow-dose computed tomography lung cancer screeningHealth-related quality-of-life dataLung cancer screening programCancer screening programCT lung cancer screeningLung cancer mortalityLow-dose CT lung cancer screeningTrial outcomesHealth benefitsScreening-related outcomesQuality-of-life dataCost-effectiveNELSON trialScreening implementationCancer mortalityNo screeningSex-stratifiedEver-smokersProstate‐specific membrane antigen positron emission tomography/computed tomography imaging as a precision diagnostic at prostate cancer recurrence after radical prostatectomy: Modeling long‐term survival
Gogebakan K, Elsisi Z, Montano‐Campos F, Owens L, Zhao Y, Gulati R, Ferdinandus J, Fendler W, Calais J, Hope T, Carlsson S, Fainberg J, Laudone V, Kunst N, Berlin A, Schipper M, Barbour A, Iravani A, Etzioni R. Prostate‐specific membrane antigen positron emission tomography/computed tomography imaging as a precision diagnostic at prostate cancer recurrence after radical prostatectomy: Modeling long‐term survival. Cancer 2025, 131: e70131. PMID: 41108673, PMCID: PMC12632154, DOI: 10.1002/cncr.70131.Peer-Reviewed Original ResearchConceptsRadical prostatectomyBiochemical recurrenceIncremental life-yearsProstate-specific Membrane Antigen Positron Emission Tomography/Computed TomographyHazard ratioPositron Emission Tomography/Computed TomographyLife yearsPositron emission tomography/computed tomography imagingHealth-related qualityEmission Tomography/Computed TomographyLong-term treatment benefitsProstate cancer recurrenceDisease-specific deathManagement of patientsLong-term outcomesProgression to metastasisLong-term survivalPostmetastasis survivalPSMA PET/CTSalvage regimensSystemic regimensDecision-analytic modelSalvage treatmentTomography/Computed TomographySurvival benefitCost-Effectiveness and Evidence Gaps Surrounding PSMA-PET for Recurrent Prostate Cancer Evaluation
Kunst N, Long J, Sprenkle P, Kim I, Saperstein L, Rabil M, Ghaffar U, Karnes R, Ma X, Gross C, Wang S, Leapman M. Cost-Effectiveness and Evidence Gaps Surrounding PSMA-PET for Recurrent Prostate Cancer Evaluation. JAMA Network Open 2025, 8: e2539250. PMID: 41134573, PMCID: PMC12552925, DOI: 10.1001/jamanetworkopen.2025.39250.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioQuality-adjusted life yearsPSMA-PETBiochemical recurrenceProstate cancerProstate-specific membrane antigen positron emission tomographyLow prostate-specific antigen levelsBiochemically recurrent prostate cancerProstate-specific antigen levelMetastatic prostate cancerProstate cancer evaluationStudy of patientsUS academic centersLifetime quality-adjusted life yearsTreatment costsCost-effectiveness ratioPositron emission tomographyDecision-analytic modelDefinitive surgeryRadiation therapyMolecular imagingAntigen levelsBone scanPatient subsetsReflex testLong-Term Outcomes and Cost-Effectiveness of Artificial Intelligence for Breast Cancer Screening: A Modeling Study
Andersen M, Kunst N, Richman I. Long-Term Outcomes and Cost-Effectiveness of Artificial Intelligence for Breast Cancer Screening: A Modeling Study. Value In Health 2025, 29: 179-188. PMID: 40983310, DOI: 10.1016/j.jval.2025.09.005.Peer-Reviewed Original ResearchBreast cancer screeningQuality-adjusted life yearsBreast cancer deathsBreast cancer casesCancer screeningIncremental cost-effectiveness ratioDigital breast tomosynthesisBreast Cancer Surveillance ConsortiumCancer casesLong-term health outcomesBreast cancer mortalityCancer deathNegative screeningNationally representative dataCost-effectiveBiennial screeningAdvanced breast cancer casesHealth outcomesCancer mortalityCost-effectiveness ratioWomen ageStandardized screeningLife yearsRepresentative dataRoutine practiceModeling the Impact of Multicancer Early Detection Tests: A Review of Natural History of Disease Models
Mandrik O, Whyte S, Kunst N, Rayner A, Harden M, Dias S, Payne K, Palmer S, Soares M. Modeling the Impact of Multicancer Early Detection Tests: A Review of Natural History of Disease Models. Medical Decision Making 2025, 45: 1013-1024. PMID: 40753481, PMCID: PMC12511643, DOI: 10.1177/0272989x251351639.Peer-Reviewed Original ResearchMulticancer early detectionNatural history of diseaseHistory of diseaseTrial evidenceMulticancer early detection testsAbsence of trial evidenceScreening clinical trialsCancer screening modelStage shiftEarly detection testsEarly detectionCritical appraisalNatural historyMortality impactClinical study evidenceMortality effectsTest accuracyCost-effectiveEvaluation approachClinical studiesClinical trialsPublished estimatesMortalityAppraisalStudy evidence