Brent Vander Wyk, PhD
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Core Co-Leader, Geriatrics Staff
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Biostatistician
Core Co-Leader, Geriatrics StaffBiography
Dr. Vander Wyk is a biostatistician in the Yale OAIC Biostatistics Core. He provides expertise in study design, statistical analyses, and research programming. Since joining Yale’s Program on Aging in 2018, his work has focused on physical and cognitive changes related to aging and the development of methods and statistical analyses to address complex, multimodal datasets that arise in longitudinal studies, functional neuroimaging, administrative records, human immunology and animal models.
Education & Training
- PhD
- Carnegie Mellon Univ, Psychology (2006)
- BSc
- University of Connecticut, Psychology (2000)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Brent Vander Wyk's published research.
Publications Timeline
A big-picture view of Brent Vander Wyk's research output by year.
Heather Allore, PhD
Sandra Ann Springer, MD
Thomas M. Gill, MD
Albert C Shaw, MD, PhD
Mika Naganawa, PhD
Ming-Kai Chen, MD, PhD
71Publications
2,375Citations
Publications
2024
Missed Opportunities for Pre-Exposure Prophylaxis Initiation in Hospitalized Persons with Opioid Use Disorder and Infectious Diseases
Parchinski K, Neirinckx V, Frank C, Di Paola A, Tarfa A, Shenoi S, Vander WyK B, Roth P, Ghantous T, Wegman M, Strong M, Levin F, Brady K, Nunes E, Litwin A, Springer S. Missed Opportunities for Pre-Exposure Prophylaxis Initiation in Hospitalized Persons with Opioid Use Disorder and Infectious Diseases. Open Forum Infectious Diseases 2024, ofae366. DOI: 10.1093/ofid/ofae366.Peer-Reviewed Original ResearchNational Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort studyPrior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters
Di Pietro C, Haberman A, Lindenbach B, Smith P, Bruscia E, Allore H, Vander Wyk B, Tyagi A, Zeiss C. Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters. Viruses 2024, 16: 246. PMID: 38400021, PMCID: PMC10891789, DOI: 10.3390/v16020246.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransient gene expressionSARS-CoV-2Viral replication pathwayReplication pathwayAntiviral pathwaysEndemism patternsUpregulation of innateGene expressionQuantitative RT-PCRMitigated weight lossDual-infected animalsSARS-CoV-2 viral loadSARS-CoV-2 infectionSyrian hamstersSeasonal infection ratesSARS-CoV-2 inoculationLungs of animalsIndividual virusesSARS-CoV-2 diseaseUpper respiratory tractH1N1 infectionRT-PCRBronchoalveolar lavageViral loadCytokine levelsLongitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients
Liu R, Vander Wyk B, Quiñones A, Allore H. Longitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients. Research On Aging 2024, 46: 327-338. PMID: 38261524, DOI: 10.1177/01640275241229162.Peer-Reviewed Original ResearchAltmetricConceptsSkilled-nursing facilityCare recipientsNational Health and Aging Trends StudyGeneralized estimating equation modelsCenters for MedicareLikelihood of hospitalizationMedicaid Services dataCaregiver networkUnpaid caregiversHealthcare utilizationTrends StudyAssociated healthcare utilizationOlder adultsCaregiversRisk ratioSurvey wavesService dataCareHospitalAssociationAdmissionMedicareMedicaidAdultsEquation modeling
2023
PERSONALIZED AND TYPICAL CONCURRENT RISK: JOINT MODELS OF RECURRENT OUTCOMES AND MORTALITY BY RACE/ETHNICITY
Allore H, McAvay G, Vander Wyk B, Han L, Quiñones A. PERSONALIZED AND TYPICAL CONCURRENT RISK: JOINT MODELS OF RECURRENT OUTCOMES AND MORTALITY BY RACE/ETHNICITY. Innovation In Aging 2023, 7: 231-231. PMCID: PMC10736438, DOI: 10.1093/geroni/igad104.0759.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsChronic conditionsRisk factorsConcurrent riskSociodemographic risk factorsPoor health outcomesHuman Services initiativeHealthcare system policiesRace/ethnicityFunctional statusHigh riskHealth outcomesHealth statusHealth servicesAverage riskPatient trajectoriesPopulation subgroupsOutcomesRecurrent outcomesRiskCohort levelConcurrent outcomesRandom intercept termLongitudinal effectsMultiple outcomesCONTRIBUTION OF CHRONIC CONDITIONS TO MORTALITY: DIFFERENCES BY RACE AND ETHNICITY
Quiñones A, Elman M, McAvay G, Vander Wyk B, Nagel C, Allore H. CONTRIBUTION OF CHRONIC CONDITIONS TO MORTALITY: DIFFERENCES BY RACE AND ETHNICITY. Innovation In Aging 2023, 7: 763-764. PMCID: PMC10738322, DOI: 10.1093/geroni/igad104.2468.Peer-Reviewed Original ResearchConceptsNeurodegenerative conditionsLung diseasePreventative care servicesHealth care utilizationAverage attributable fractionNon-Hispanic whitesBlack older adultsRace/ethnicityCare utilizationChronic conditionsAttributable fractionCardiovascular diseaseCare servicesEthnic groupsSociodemographic characteristicsHealth disparitiesHispanic participantsMortalityOlder adultsDiseaseBlack participantsEthnic differencesDiabetesWhite participantsDementiaEarly cellular and molecular signatures correlate with severity of West Nile virus infection
Lee H, Zhao Y, Fleming I, Mehta S, Wang X, Vander Wyk B, Ronca S, Kang H, Chou C, Fatou B, Smolen K, Levy O, Clish C, Xavier R, Steen H, Hafler D, Love J, Shalek A, Guan L, Murray K, Kleinstein S, Montgomery R. Early cellular and molecular signatures correlate with severity of West Nile virus infection. IScience 2023, 26: 108387. PMID: 38047068, PMCID: PMC10692672, DOI: 10.1016/j.isci.2023.108387.Peer-Reviewed Original ResearchCitationsAltmetricConceptsWest Nile virusEffective anti-viral responseInnate immune cell typesWest Nile virus infectionPro-inflammatory markersAcute time pointsImmune cell typesAnti-viral responseMolecular signaturesHost cellular activitiesAcute infectionAsymptomatic donorsPeripheral bloodSevere infectionsVirus infectionImmune responseSevere casesCell activityIll individualsSerum proteomicsInfectionInfection severityHigh expressionTime pointsNile virusA Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries-Differences by Chronic Disease and Race/Ethnicity.
Quiñones A, McAvay G, Vander Wyk B, Han L, Nagel C, Allore H. A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries-Differences by Chronic Disease and Race/Ethnicity. Journal Of Aging And Health 2023, 8982643231210027. PMID: 37879084, DOI: 10.1177/08982643231210027.Peer-Reviewed Original ResearchAltmetricConceptsPoor self-rated healthSelf-rated healthHigher oddsADL disabilityHip fractureAging Trends Study dataOlder adultsConcurrent riskPatient-centered outcomesLongitudinal logistic regression modelsLogistic regression modelsRace/ethnicityKidney diseaseChronic diseasesNational HealthDaily livingMortalityHealth declineOddsDisabilityHispanic respondentsDementiaDiseaseRiskWide variabilityDectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIVAssociations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study
Monin J, McAvay G, Zang E, Vander Wyk B, Carrión C, Allore H. Associations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study. PLOS ONE 2023, 18: e0289311. PMID: 37585365, PMCID: PMC10431668, DOI: 10.1371/journal.pone.0289311.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAdjusted odds ratioAlzheimer's Disease Research CenterAgitation/aggressionDepression/dysphoriaCase-control studyElation/euphoriaNational Alzheimer's Coordinating CenterDisease Research CenterBehavioral symptomsDivorce/separationOlder adultsCoordinating CenterDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitOdds ratioIndividual symptomsNPI scoresStandardized clinical informationClinical informationMarried casesGreater oddsControl study
Clinical Trials
Current Trials
Comprehensive Therapy for Irritability in Teenagers with Autism Study
HIC ID0102012121RoleSub InvestigatorPrimary Completion Date12/31/2025Recruiting ParticipantsGenderBothAge11 years - 16 yearsEffects of circadian regulation and sleep on immune responses
HIC ID2000027037RoleSub InvestigatorPrimary Completion Date02/28/2025Recruiting ParticipantsGenderBothAge21+ yearsAn Intervention to Reduce Readmission Rates in Young Women with Acute Myocardial Infarction (AMI)
HIC ID2000026617RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsCBT for Anxiety in Children With Autism
HIC ID1211011144RoleSub InvestigatorPrimary Completion Date06/30/2020Recruiting ParticipantsGenderBothAge8 years - 14 years
Academic Achievements and Community Involvement
activity Member
Professional OrganizationsGerontological Society of AmericaDetails2018 - Presentactivity Member
Professional OrganizationsSociety for NeuroscienceDetails2011 - 2018activity Member
Professional OrganizationsCognitive Neuroscience SocietyDetails2010 - 2018activity Member
Professional OrganizationsInternational Society for Autism ResearchDetails2010 - 2018activity Editorial Board Member
Journal ServiceJournal of Autism and Developmental DisordersDetails2013 - 2018
Links & Media
News
- May 07, 2024
48 Internal Medicine Staff Members Celebrate Service Anniversaries
- February 28, 2024Source: YaleNews
Risk of Hospital Readmission After Surgery Is High for Older Americans
- March 24, 2023Source: Aging Cell
Platelet response to influenza vaccination reflects effects of aging
- March 16, 2023
Discoveries & Impact (March 2023)