Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes
Reese PP, Hall IE, Weng FL, Schröppel B, Doshi MD, Hasz RD, Thiessen-Philbrook H, Ficek J, Rao V, Murray P, Lin H, Parikh CR. Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes. Journal Of The American Society Of Nephrology 2015, 27: 1534-1543. PMID: 26374609, PMCID: PMC4849827, DOI: 10.1681/asn.2015040345.Peer-Reviewed Original ResearchConceptsDelayed graft functionRecipient delayed graft functionKidney injury molecule-1Graft functionInjury biomarkersDonor AKIDeceased donor organ qualityLiver-type fatty acidEarly allograft functionL-FABP concentrationRecipient renal functionUrinary NGAL concentrationsKidney transplant recipientsInjury molecule-1Kidney transplant outcomesAllograft functionUrinary NGALKidney injuryTransplant outcomesTransplant recipientsNGAL concentrationsRenal functionNeutrophil gelatinaseDeceased donorsIL-18Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery
Zhang WR, Garg AX, Coca SG, Devereaux PJ, Eikelboom J, Kavsak P, McArthur E, Thiessen-Philbrook H, Shortt C, Shlipak M, Whitlock R, Parikh CR. Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery. Journal Of The American Society Of Nephrology 2015, 26: 3123-3132. PMID: 25855775, PMCID: PMC4657830, DOI: 10.1681/asn.2014080764.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCanadaCardiac Surgical ProceduresCreatinineFemaleFollow-Up StudiesHumansInterleukin-10Interleukin-6Lipocalin-2LipocalinsMaleMiddle AgedPostoperative PeriodPreoperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsUnited StatesConceptsIL-10 concentrationsIL-6 concentrationsPlasma IL-6IL-6IL-10Cardiac surgeryHigh riskLower riskPeak IL-6 concentrationNeutrophil gelatinase-associated lipocalinPathophysiology of AKIPostoperative IL-6Long-term mortalityGelatinase-associated lipocalinBiomarkers of inflammationRisk of mortalityDose-dependent mannerHospital AKIAKI biomarkersCause mortalityPerioperative outcomesPreoperative concentrationsSerum creatinineDL increaseSecond tertile