Data Service
Data Sources
The Cardiovascular Medicine Analytics Center also serves as a data hub to support the Department of Cardiovascular Medicine and to establish a space for data curation and catalog for investigators to preserve or share research data. Whether you're in need of secure data storage solutions or seeking access to our extensive data collections, our data hub is equipped to meet all your research needs. We invite researchers and professionals within the cardiovascular field to take advantage of this invaluable resource. If you have data storage requirements or wish to request access to our data, please do not hesitate to reach out and request our services. Join us in advancing cardiovascular medicine through collaborative research and data sharing.
STICH [and STICHES]
Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease(STICH, 2002-2007; STICHES till 2015) is a multicenter, international, randomized trial that addresses two specific primary hypotheses in patients with clinical heart failure (HF) and left ventricular (LV) dysfunction who have coronary artery disease amenable to surgical revascularization.
The first hypothesis (N=1,212) is that restoration of blood flow by means of coronary revascularization recovers chronic LV dysfunction and improves survival, as compared to intensive medical therapy alone. The second hypothesis (N=1,000) is that surgical ventricular restoration (SVR) to a more normal LV size improves survival free of subsequent hospitalization for cardiac cause compared to CABG alone. Patients eligible for either medical therapy or CABG, but not eligible for the SVR procedure (Stratum A), were randomized in equal proportions to medical therapy alone versus CABG plus medical therapy. Patients eligible for all three therapies (Stratum B) were be randomized in equal proportions to medical therapy alone, CABG plus medical therapy, and CABG plus SVR plus medical therapy. Patients whose severity of angina or CAD makes them inappropriate for medical therapy alone (Stratum C) were randomized in equal proportions to CABG plus medical therapy versus CABG plus SVR plus medical therapy.
TRANSFORM-HF
ToRsemide compArisoN With furoSemide FORManagement of Heart Failure (TRANSFORM-HF, 2018-2022) is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. A total of N=2,859 hospitalized patients with heart failure were recruited at 60 hospitals in the United States. Heart failure need not be the reason for hospitalization. Patients were randomized 1:1 to either oral torsemide OR oral furosemide prior to hospital discharge. Oral dosing of torsemide compared to furosemide was 1mg:2mg. The specific loop diuretic dose was at the discretion of the treating physician with the above noted conversion.
The primary objective of the TRANSFORM-HF study is to compare the treatment strategy of torsemide versus furosemide on clinical outcomes over 12 months in patients with heart failure who were hospitalized. Patients had 30-day, 6-month and 12-month follow-up phone contacts for assessments of vital status, interval hospitalizations, adherence, and quality of life. Subsets of patients enrolled early in the study had additional phone contacts beyond 12 months, up to 30 months, at six-month intervals, to document vital status.
Other Resources
Computational Resources
The Cardiovascular Medicine Analytics Center offers computational solutions for research projects. We handle projects that involve large datasets or require sophisticated computational methods, such as Bayesian statistics, among other complex computational needs. Our center is equipped to consult and provide tailored solutions that will drive your research forward. Whether you're dealing with vast amounts of data or navigating the intricacies of advanced statistical models, our expertise is at your service. We encourage researchers facing computational challenges in their projects to leverage this unique opportunity. Please reach out to us for consultation for computationally intensive projects.
Other Resources
Fill out this intake form to schedule a consultation on grant proposals, research projects, and investigator-initiated studies with funding support.