Yuan Lu, ScD
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)DownloadHi-Res Photo
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Cardiovascular Medicine
Primary
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About
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Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)
Biography
Dr. Lu was trained in epidemiology and global health, with a particular focus on cardiovascular diseases. She obtained both of her ScD and MSc Degrees in Global Health and Population at the Harvard School of Public Health. She works in the intersection of cardiovascular disease prevention, health equity, and digital health, using implementation science methods to resolve real-world issues. Her long-term goal is to improve care, outcomes, and equity of cardiovascular diseases by designing and implementing technology-based interventions.
She successfully completed an NHLBI K12 career development award in implementation science. During this award, she harnessed electronic health records from the Yale New Haven Health System to identify patients with persistent hypertension and designing decision support systems to improve their care. Currently, Dr. Lu serves as the Principal Investigator for an NIH R01 grant, where she leverages real-world data from five electronic health record databases encompassing over 100 million US adults. The goal of this endeavor is to generate real-world evidence that informs decisions regarding hypertension treatment escalation.
In addition to her domestic contributions, Dr. Lu has engaged in groundbreaking collaborative projects between Yale University and the Chinese National Center for Cardiovascular Diseases in Beijing. These include the Millions Persons Project that assembles remarkable population health and biomedical resources from 5 million individuals across China. Moreover, she has collaborated with the NCD Risk Factor Collaboration (NCD-RisC) on global analyses examining the impact of risk factors on the worldwide burden of cardiovascular diseases.
She has authored over 100 peer-reviewed publications, including first author articles in leading journals such as The Lancet, JAMA, Circulation, and BMJ, and her work has been cited more than 40,000 times. Dr. Lu is the recipient of the 2022 John H. Laragh Research Award of the American Journal of Hypertension for her contribution to the field of hypertension.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Chronic Disease Epidemiology
- Internal Medicine
- Janeway Society
- Preventive Cardiovascular Health Program at Yale
- Yale UNRAVEL Study
Education & Training
- ScD
- Harvard School of Public Health, Global Health and Population (2015)
Research
Overview
Medical Subject Headings (MeSH)
Cardiovascular Diseases; Chronic Disease
ORCID
0000-0001-5264-2169- View Lab Website
Yale/YNHH Center for Outcomes Research and Evaluation (CORE)
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yuan Lu's published research.
Publications Timeline
A big-picture view of Yuan Lu's research output by year.
Research Interests
Research topics Yuan Lu is interested in exploring.
Harlan Krumholz, MD, SM
Erica Spatz, MD, MHS
Rohan Khera, MD, MS
Shiwani Mahajan, MBBS, MHS
Karthik Murugiah, MBBS, FACC, FSCAI
Cesar Caraballo-Cordovez, MD
83Publications
36,797Citations
Cardiovascular Diseases
Chronic Disease
Publications
2024
Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Faust J, Renton B, Bongiovanni T, Chen A, Sheares K, Du C, Essien U, Fuentes-Afflick E, Haywood T, Khera R, King T, Li S, Lin Z, Lu Y, Marshall A, Ndumele C, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor H, Watson K, Yancy C, Krumholz H. Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2438918. PMID: 39392630, DOI: 10.1001/jamanetworkopen.2024.38918.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCOVID-19 public health emergencyNon-HispanicPublic health emergencyOther Pacific IslanderExcess mortalityAlaska NativesUS populationExcess deathsRates of excess mortalityCross-sectional study analyzed dataYears of potential lifeMortality relative riskNon-Hispanic whitesCross-sectional studyPacific IslandersStudy analyzed dataAll-cause mortalityEthnic groupsMortality disparitiesMortality ratioTotal populationDeath certificatesEthnic disparitiesMain OutcomesDecedent ageLong-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2403960121. PMID: 39316057, PMCID: PMC11459178, DOI: 10.1073/pnas.2403960121.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsWildland firesContiguous United StatesNonaccidental mortalityExposure to ambient fine particlesSmoke PM<sWildland fire smokeMoving average concentrationsAmbient fine particlesLong-term exposureAverage concentrationSmoke PMHealth risksFine particlesFire smokeTemporal confoundingHealth effectsKidney disease mortalityChronic kidney disease mortalityPublic health actionFireMortality rateUnited StatesDisease mortalityHealth actionsMortality outcomesUse of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks
Lu Y, Keeley E, Barrette E, Cooper-DeHoff R, Dhruva S, Gaffney J, Gamble G, Handke B, Huang C, Krumholz H, McDonough C, Schulz W, Shaw K, Smith M, Woodard J, Young P, Ervin K, Ross J. Use of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks. BMC Cardiovascular Disorders 2024, 24: 497. PMID: 39289597, PMCID: PMC11409735, DOI: 10.1186/s12872-024-04161-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsElectronic health recordsHealth recordsHealth systemUncontrolled hypertensionUse of electronic health recordsHypertension managementElectronic health record systemsOneFlorida Clinical Research ConsortiumElectronic health record dataYale New Haven Health SystemBP measurementsICD-10-CM codesHealth system networkPublic health priorityICD-10-CMIncidence rate of deathElevated BP measurementsElevated blood pressure measurementsHealthcare visitsAmbulatory careHealth priorityRetrospective cohort studyEHR dataOneFloridaBlood pressure measurementsCause-Specific Mortality Rates Among the US Black Population
Arun A, Caraballo C, Sawano M, Lu Y, Khera R, Yancy C, Krumholz H. Cause-Specific Mortality Rates Among the US Black Population. JAMA Network Open 2024, 7: e2436402. PMID: 39348122, PMCID: PMC11443349, DOI: 10.1001/jamanetworkopen.2024.36402.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsFloods and cause-specific mortality in the United States during 2001-2020
Chu L, Warren J, Spatz E, Lowe S, Lu Y, Ma X, Ross J, Krumholz H, Chen K. Floods and cause-specific mortality in the United States during 2001-2020. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1705.Peer-Reviewed Original ResearchShort-term association between ambient ozone and onset of acute myocardial infarction of young patients: Results from the VIRGO study
Zhang S, Chu L, Lu Y, Krumholz H, Chen K. Short-term association between ambient ozone and onset of acute myocardial infarction of young patients: Results from the VIRGO study. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0539.Peer-Reviewed Original ResearchLong-term exposure to wildfire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildfire smoke PM2.5 and mortality in the contiguous United States. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1154.Peer-Reviewed Original ResearchEffect of the COVID-19 Pandemic on Monitoring and Control of Cardiovascular Risk Factors and Disparities
Lu Y, Brush J, Liu Y, Li S, Asher J, Krumholz H. Effect of the COVID-19 Pandemic on Monitoring and Control of Cardiovascular Risk Factors and Disparities. JACC Advances 2024, 3: 101177. PMID: 39220712, PMCID: PMC11364117, DOI: 10.1016/j.jacadv.2024.101177.Peer-Reviewed Original ResearchConceptsBarriers to Optimal Clinician Guideline Adherence in Management of Markedly Elevated Blood Pressure
Lu Y, Arowojolu O, Qiu X, Liu Y, Curry L, Krumholz H. Barriers to Optimal Clinician Guideline Adherence in Management of Markedly Elevated Blood Pressure. JAMA Network Open 2024, 7: e2426135. PMID: 39106065, PMCID: PMC11304113, DOI: 10.1001/jamanetworkopen.2024.26135.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBarriers to guideline adherenceElectronic health recordsGuideline adherenceClinician adherenceEHR dataElevated blood pressureHypertension managementAnalysis of EHR dataYale New Haven Health SystemSevere hypertensionClinical practice guidelinesAdherence scenariosQualitative content analysisPublic health challengeThematic saturationHealth recordsHealth systemBlood pressureThematic analysisTargeted interventionsManagement of severe hypertensionQualitative studyHealth challengesPractice guidelinesPatient outcomesInternal tremors and vibrations in long COVID: a cross-sectional study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal tremors and vibrations in long COVID: a cross-sectional study. The American Journal Of Medicine 2024 PMID: 39069199, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disorders
Academic Achievements & Community Involvement
activity National Institutes of Health (NIH)
Peer Review Groups and Grant Study SectionsReviewerDetails06/01/2023 - Presentactivity JACC
Journal ServiceAssociate EditorDetails02/01/2024 - Presentactivity American Heart Association
Professional OrganizationsFellowDetails07/01/2021 - Presentactivity Unraveling the Interplay between Age, Obesity, and Mortality across Adulthood: Insights from National Health and Nutrition Examination Survey 1999-2018
Poster PresentationAmerican Heart Association Scientific Sessions 2023Details11/11/2023 - 11/13/2023Philadelphia, PA, United Statesactivity Disparities in Low Cognitive Function Score and Mortality Risk Among Older Adults in the United States
Poster PresentationAmerican Heart Association Scientific Sessions 2023Details11/11/2023 - 11/13/2023Philadelphia, PA, United States
News
News
- September 24, 2024
Long-term exposure to wildfire smoke associated with higher risk of death
- August 08, 2024Source: MedCentral
Physicians Are Not Adhering to Severe Hypertension Care Guidelines
- July 02, 2024
Yale Faculty Members Named to JACC Editorial Board
- May 28, 2024
Next Generation Research Uses Real-World Data to Identify Most Effective Hypertension Drugs for Patients
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Yale Center for Outcomes Research and Evaluation
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New Haven, CT 06510