Yoshitaka Kimura
Associate Research ScientistCards
Contact Info
Immunobiology
300 Cedar Street, TAC S640
New Haven, Connecticut 06520-8011
United States
About
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Titles
Associate Research Scientist
Education & Training
- Associate Research Scientist
- Yale University School of Medicine
- Postdoctoral Fellow
- Yale University School of Medicine (2022)
- Project Researcher
- The University of Tokyo (2018)
- PhD
- The University of Tokyo, Pharmaceutical Sciences (2016)
- MS
- The University of Tokyo, Pharmaceutical Sciences (2013)
- BS
- The University of Tokyo, Pharmaceutical Sciences (2011)
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Yoshitaka Kimura's published research.
Publications Timeline
A big-picture view of Yoshitaka Kimura's research output by year.
Anjelica Gonzalez, PhD
Ruslan Medzhitov, PhD
10Publications
54Citations
Publications
2024
Mechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2021
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.
Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. Nat Immunol 2021, 22: 947-957. PMID: 34239121, DOI: 10.1038/s41590-021-00967-5.Peer-Reviewed Original ResearchSignal-transducing innate receptors in tumor immunity.
Hangai S, Kimura Y, Taniguchi T, Yanai H. Signal-transducing innate receptors in tumor immunity. Cancer Sci 2021, 112: 2578-2591. PMID: 33570784, DOI: 10.1111/cas.14848.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.
Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H. Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways. Cancer Sci 2018, 109: 2687-2696. PMID: 29981256, DOI: 10.1111/cas.13726.Peer-Reviewed Original ResearchRevisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.
Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T. Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proc Natl Acad Sci U S A 2018, 115: 5253-5258. PMID: 29712834, DOI: 10.1073/pnas.1803936115.Peer-Reviewed Original Research
2017
Innate immune receptors in the regulation of tumor immunity
Hangai S, Kimura Y, Taniguchi T, Yanai H. Innate immune receptors in the regulation of tumor immunity. Oncoimmunology: A Practical Guide for Cancer Immunotherapy 2017; 407-427.Chapters
2016
The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.
Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. Proc Natl Acad Sci U S A 2016, 113: 14097-14102. PMID: 27872290, DOI: 10.1073/pnas.1617903113.Peer-Reviewed Original ResearchIL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.
Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y. IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. Cancer Sci 2016, 107: 1206-14. PMID: 27384869, DOI: 10.1111/cas.13005.Peer-Reviewed Original ResearchPGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H. PGE2 induced in and released by dying cells functions as an inhibitory DAMP. Proc Natl Acad Sci U S A 2016, 113: 3844-9. PMID: 27001836, DOI: 10.1073/pnas.1602023113.Peer-Reviewed Original Research
2014
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. Elife 2014, 3: e04177. PMID: 25149452, DOI: 10.7554/eLife.04177.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity Proteostasis maintenance by macrophage trogocytosis
06/01/2025 - 07/06/2025Oral PresentationGordon Research Conference "Phagocytes"DetailsWaterville Valley, NH, United StatesCollaborators- Yoshitaka Kimura
- Arun Chavan
- Kazuki Sato, PhD
- Scott PopeYale University School of Medicine
- Naomi PhilipYale University School of Medicine
- Gang-Qing Yao, MD
- Karl Insogna, MD, FACP
- Xiaolei Su, PhD
- Ruslan Medzhitov, PhD
activity JSI Newsletter, Japanese Society for Immunology
02/03/2025 - 03/21/2025Public ServiceAuthoractivity Proteostasis maintenance by macrophage trogocytosis
05/03/2024 - 05/07/2024Oral PresentationThe Annual Meeting of The American Association of Immunologists, IMMUNOLOGY 2024DetailsChicago, IL, United StatesCollaborators- Yoshitaka Kimura
- Arun Chavan
- Naomi Philip
- Ruslan Medzhitov, PhD
activity Proteostasis maintenance by macrophage trogocytosis
04/24/2024 - 04/28/2024Oral PresentationCSHL Meeting, Protein Homeostasis in Health and Disease 2024DetailsCold Spring Harbor, NY, United StatesCollaborators- Yoshitaka Kimura
- Arun Chavan
- Naomi Philip
- Ruslan Medzhitov, PhD
activity Proteostasis maintenance by macrophage trogocytosis
12/02/2023 - 12/03/2023Oral PresentationThe New England Immunology Conference 2023DetailsFalmouth, MA, United StatesCollaborators- Yoshitaka Kimura
- Arun Chavan
- Naomi Philip
- Ruslan Medzhitov, PhD
Honors
honor Encouragement Award
04/25/2025Other AwardUnited Japanese researchers Around the worldhonor Trainee Abstract Award
03/07/2024Other AwardThe American Association of ImmunologistsDetailsUnited Stateshonor Poster award
12/03/2023Other AwardNew England Immunology ConferenceDetailsUnited Stateshonor JSPS Overseas Research Fellowships
05/14/2020National AwardJapan Society for the Promotion of ScienceDetailsJapanhonor Postdoctoral Fellowship
05/14/2018Other AwardThe Uehara Memorial FoundationDetailsJapan
Teaching & Mentoring
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Mentoring
Sofía Vieto Fonseca
Graduate student2022 - 2023
Get In Touch
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Contacts
Mailing Address
Immunobiology
300 Cedar Street, TAC S640
New Haven, Connecticut 06520-8011
United States