Featured Publications
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Hu W, Wang Z, Feng Y, Schizas M, Hoyos B, van der Veeken J, Verter J, Bou-Puerto R, Rudensky A. Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nature Immunology 2021, 22: 1163-1174. PMID: 34426690, PMCID: PMC9341271, DOI: 10.1038/s41590-021-01001-4.Peer-Reviewed Original ResearchConceptsRegulatory T cellsTreg cellsFatal autoimmune diseaseSystemic inflammationAutoimmune diseasesT cellsPro-inflammatory effector cellsFatal autoimmune inflammationFOXP3 protein expressionSevere tissue inflammationTranscription factor Foxp3Autoimmune inflammationFatal autoimmunityInflammatory mediatorsEffector cellsImmune activationImmunosuppressive functionTissue inflammationDiseased miceImmune homeostasisInflammatory responseFactor Foxp3Long-term protectionInflammationLoss of functionExpression of Foxp3 by T follicular helper cells in end-stage germinal centers
Jacobsen J, Hu W, R Castro T, Solem S, Galante A, Lin Z, Allon S, Mesin L, Bilate A, Schiepers A, Shalek A, Rudensky A, Victora G. Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science 2021, 373 PMID: 34437125, PMCID: PMC9007630, DOI: 10.1126/science.abe5146.Peer-Reviewed Original ResearchConceptsFollicular helper cellsGerminal centersHelper cellsFormation of GCsExpression of Foxp3Effective antibody responseTranscription factor Foxp3Acute surgeAntibody responseFactor Foxp3T cellsFoxp3Immunoglobulin somatic hypermutationGC sizeAffinity maturationPotential regulatorCellsEctopic expressionSomatic hypermutationExpressionAntibodies
2023
Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies
Glasner A, Rose S, Sharma R, Gudjonson H, Chu T, Green J, Rampersaud S, Valdez I, Andretta E, Dhillon B, Schizas M, Dikiy S, Mendoza A, Hu W, Wang Z, Chaudhary O, Xu T, Mazutis L, Rizzuto G, Quintanal-Villalonga A, Manoj P, de Stanchina E, Rudin C, Pe’er D, Rudensky A. Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nature Immunology 2023, 24: 1020-1035. PMID: 37127830, PMCID: PMC10232368, DOI: 10.1038/s41590-023-01504-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansMiceNeoplasmsT-Lymphocytes, RegulatoryTumor MicroenvironmentVascular Endothelial Growth Factor AConceptsTreg cell depletionRegulatory T cellsT cellsCell depletionEffector T cellsInjury-induced inflammationTreg cell functionSolid organ cancersAntigen presenting cellsExperimental lung cancerLung adenocarcinoma progressionAccessory cell typesT cell activationRational combination treatmentsTreg cellsCorresponding monotherapiesOrgan cancersLung cancerInjury settingPresenting cellsVEGF blockadeAdenocarcinoma progressionCombination treatmentMyeloid cellsCell activation
2022
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells
van der Veeken J, Campbell C, Pritykin Y, Schizas M, Verter J, Hu W, Wang Z, Matheis F, Mucida D, Charbonnier L, Chatila T, Rudensky A. Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity 2022, 55: 1173-1184.e7. PMID: 35700740, PMCID: PMC9885886, DOI: 10.1016/j.immuni.2022.05.010.Peer-Reviewed Original ResearchMeSH KeywordsForkhead Transcription FactorsImmune ToleranceTh17 CellsThymocytesT-Lymphocytes, RegulatoryConceptsPTreg cellsTranscription factor Foxp3Treg cellsFactor Foxp3Absence of Foxp3Foxp3-independent mannerPeripheral Treg cellsRegulatory T cellsRole of Foxp3Genetic tracingSuppress autoimmunityTolerogenic signalsEffector TT cellsFoxp3Mature CD4Commensal microbiotaCell lineagesCellsCell expansionCell programTTregsColitisCD4Autoimmunity
2020
The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries
van der Veeken J, Glasner A, Zhong Y, Hu W, Wang Z, Bou-Puerto R, Charbonnier L, Chatila T, Leslie C, Rudensky A. The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity 2020, 53: 971-984.e5. PMID: 33176163, PMCID: PMC8363055, DOI: 10.1016/j.immuni.2020.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBinding SitesChromatin Assembly and DisassemblyDisease Models, AnimalEpigenesis, GeneticFemaleForkhead Transcription FactorsGene Expression RegulationImmunohistochemistryMaleMiceNucleotide MotifsOrgan SpecificityProtein BindingT-Lymphocytes, RegulatoryTrans-ActivatorsConceptsRegulatory T Cell IdentityChromatin accessibilityCell identityT cell identityDNA sequence motifsGene expression patternsMajor chromatinChromatin regionsTF bindingSequence motifsTCF7 geneEpigenetic featuresGenetic variationNegative regulationNull allelesExpression patternsPresence of DNATreg cell identityFOXP3 functionTCF1MotifIndirect mannerCellsTranscription factor Foxp3Chromatin