Wei Hu, PhD
she/her/hers
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Research
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Featured Publications
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Hu W, Wang Z, Feng Y, Schizas M, Hoyos B, van der Veeken J, Verter J, Bou-Puerto R, Rudensky A. Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nature Immunology 2021, 22: 1163-1174. PMID: 34426690, PMCID: PMC9341271, DOI: 10.1038/s41590-021-01001-4.Peer-Reviewed Original ResearchExpression of Foxp3 by T follicular helper cells in end-stage germinal centers
Jacobsen J, Hu W, R Castro T, Solem S, Galante A, Lin Z, Allon S, Mesin L, Bilate A, Schiepers A, Shalek A, Rudensky A, Victora G. Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science 2021, 373: eabe5146. PMID: 34437125, PMCID: PMC9007630, DOI: 10.1126/science.abe5146.Peer-Reviewed Original ResearchDifferential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
Hu W, Jain A, Gao Y, Dozmorov I, Mandraju R, Wakeland E, Pasare C. Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 13994-13999. PMID: 26508631, PMCID: PMC4653191, DOI: 10.1073/pnas.1510760112.Peer-Reviewed Original ResearchAdaptor Proteins, Vesicular TransportAnimalsBase SequenceBlotting, WesternCD4-Positive T-LymphocytesCell ProliferationDendritic CellsFlow CytometryGene Expression RegulationLipopolysaccharidesMiceMice, KnockoutMolecular Sequence DataSequence Analysis, RNASignal TransductionToll-Like Receptor 3Toll-Like Receptor 4IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
Lin K, Hu W, Troutman T, Jennings M, Brewer T, Li X, Nanda S, Cohen P, Thomas J, Pasare C. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 111: 775-780. PMID: 24379360, PMCID: PMC3896167, DOI: 10.1073/pnas.1320294111.Peer-Reviewed Original ResearchPriming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment
Hu W, Troutman T, Edukulla R, Pasare C. Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment. Immunity 2011, 35: 1010-1022. PMID: 22137454, PMCID: PMC3246047, DOI: 10.1016/j.immuni.2011.10.013.Peer-Reviewed Original Research
2025
Divergent proteome tolerance against gain and loss of chromosome arms
Di Y, Li W, Castellano J, Jin W, Modi J, Salovska B, Khosroabadi D, Hu W, Taylor A, Liu Y. Divergent proteome tolerance against gain and loss of chromosome arms. Molecular Cell 2025, 85: 4268-4278.e6. PMID: 41270725, PMCID: PMC12991381, DOI: 10.1016/j.molcel.2025.10.023.Peer-Reviewed Original ResearchThis study investigates how cells tolerate chromosome arm aneuploidy, showing distinct mechanisms where protein degradation compensates for gains, while synthesis upregulates proteins in losses to maintain balance.Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells
Hu W, Dolsten G, Wang E, Beroshvili G, Wang Z, Ghelani A, Uhl L, Bou-Puerto R, Huang X, Michaels A, Hoyos B, Jin W, Pritykin Y, Rudensky A. Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells. Nature Immunology 2025, 26: 2059-2073. PMID: 41062655, PMCID: PMC12571910, DOI: 10.1038/s41590-025-02295-4.Peer-Reviewed Original Research
2024
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey
Campbell C, Funk M, Hattori Y, Hu W, Jeschke J, Lau C, Ling G, Liu S, Lloréns-Rico V, Nemes E. Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey. Journal Of Experimental Medicine 2024, 221: e20240842. PMID: 38861021, PMCID: PMC11167372, DOI: 10.1084/jem.20240842.Peer-Reviewed Original ResearchGOSpel for tiny allies
Hu W, Yu X. GOSpel for tiny allies. Cell Host & Microbe 2024, 32: 450-452. PMID: 38604124, DOI: 10.1016/j.chom.2024.03.008.Peer-Reviewed Original Research
2023
Distinct metabolic requirements regulate B cell activation and germinal center responses
Sharma R, Smolkin R, Chowdhury P, Fernandez K, Kim Y, Cols M, Alread W, Yen W, Hu W, Wang Z, Violante S, Chaligné R, Li M, Cross J, Chaudhuri J. Distinct metabolic requirements regulate B cell activation and germinal center responses. Nature Immunology 2023, 24: 1358-1369. PMID: 37365386, PMCID: PMC11262065, DOI: 10.1038/s41590-023-01540-y.Peer-Reviewed Original Research
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