Anthony N. Brady Professor of Dermatology, Pathology and Immunobiology; Director, Yale SPORE in Skin Cancer; Director, Yale Center for Immuno-Oncology; Co-Leader, Cancer Immunology, Yale Cancer Center
Fundamental Mechanisms of Immunity
Research in the department examines the fundamentals of the immune system at multiple levels: development, activation, regulation, and evolution. Studies of lymphocyte and innate immune cell development examine the receptors and signals that control lineage commitment, cell maturation, and cell death; the establishment of the proper environments for cellular development; and the mechanisms by which antibody and T cell receptor genes are assembled and diversified. A critical first step in an effective immune response is the activation of cells of the innate immune system, including monocytes, macrophages, dendritic cells, and neutrophils.
Research examines the receptors and signaling molecules that control these processes, the mechanism by which cells process and present antigen, and the recognition of this antigen by T cell receptors on T lymphocytes. Upon activation, T and B cells differentiate and acquire critical effector functions including the production of cytotoxic anti-pathogen molecules and antibodies. Studies in the department examine the tissue spatial context and cellular interactions that influence effector lineage fate decisions, cytoplasmic signal transduction molecules, nuclear transcription factors, and mechanisms controlling gene expression during differentiation. Finally, resolution of the immune response (leading to scarring or healing) and the evolution of adaptive immunity are under study.
Faculty
United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)
Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Paul B. Beeson Professor of Medicine, Internal Medicine: Rheumatology; Program Director, Investigative Medicine, Internal Medicine: Rheumatology
Eugene Higgins Professor of Immunobiology and Professor of Cell Biology
Waldemar Von Zedtwitz Professor of Pathology and Professor of Immunobiology; Director, Yale Center for Research on Aging (Y-Age), Pathology
Sterling Professor of Immunobiology; Investigator, Howard Hughes Medical Institute
Associate Professor of Immunobiology; Director, In Vivo Imaging Facility, Yale School of Medicine; Scientific Director, Flow Cytometry Research Facility, YSM central core
William S. and Lois Stiles Edgerly Professor of Neurology and Professor of Immunobiology; Chair, Neurology; Neurologist-in-Chief, Yale New Haven Hospital
Sterling Professor of Immunobiology and Professor of Dermatology and of Molecular, Cellular, and Developmental Biology and of Epidemiology (Microbial Diseases); Investigator, Howard Hughes Medical Institute, (HHMI)
Professor of Laboratory Medicine, of Immunobiology and of Molecular, Cellular, and Developmental Biology; Vice Chair for Diversity, Equity and Inclusion, Laboratory Medicine; Vice Chair of Diversity, Immunobiology; Institutional Leader, CIRTL Network, CIRTL Network
Professor of Microbial Pathogenesis and of Immunobiology; Member, Yale Systems Biology Institute; Investigator, Howard Hughes Medical Institute
Sterling Professor of Immunobiology; Investigator, Howard Hughes Medical Institute
Bayer Professor of Translational Medicine and Professor of Immunobiology, Pathology and Dermatology; Director, Human and Translational Immunology Program; Vice-Chair, Dept. of Immunobiology for the Section of Human and Translational Immunology
Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology; Co-Leader, Cancer Immunology, Yale Cancer Center