Anthony N. Brady Professor of Dermatology, Pathology and Immunobiology; Director, Yale SPORE in Skin Cancer; Director, Yale Center for Immuno-Oncology; Co-Leader, Cancer Immunology, Yale Cancer Center
The Human Immune System
The immune system has evolved to deal with many different challenges, some of which can vary widely among vertebrate species, and thus while many basic mechanisms may be shared between humans and various animal models, the human immune system has evolved to differ in important ways from that of commonly used experimental rodents. Furthermore, human diseases, especially chronic disorders, are also significantly more complex than commonly used disease models, and the approaches to studying human immunity, for ethical reasons, must be often fundamentally different from those used in experimental systems. New immunotherapies, especially those based on the use of biologicals, have created an opportunity to ethically investigate human immunology and improve the value of clinical trials. The Human and Translational Immunology (HTI) section of the Immunobiology department studies both the immune systems of healthy individuals, the roles that immunology plays in a variety of human disease and analyzes the alterations that therapies may have on the immune response. HTI investigators also develop new approaches for human investigation and create new experimental models that better replicate human immunity.
Faculty
United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)
Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Paul B. Beeson Professor of Medicine, Internal Medicine: Rheumatology; Program Director, Investigative Medicine, Internal Medicine: Rheumatology
Sterling Professor of Immunobiology; Investigator, Howard Hughes Medical Institute
William S. and Lois Stiles Edgerly Professor of Neurology and Professor of Immunobiology; Chair, Neurology; Neurologist-in-Chief, Yale New Haven Hospital
Sterling Professor of Immunobiology and Professor of Dermatology and of Molecular, Cellular, and Developmental Biology and of Epidemiology (Microbial Diseases); Investigator, Howard Hughes Medical Institute, (HHMI)
Professor of Microbial Pathogenesis and of Immunobiology; Member, Yale Systems Biology Institute; Investigator, Howard Hughes Medical Institute
Bayer Professor of Translational Medicine and Professor of Immunobiology, Pathology and Dermatology; Director, Human and Translational Immunology Program; Vice-Chair, Dept. of Immunobiology for the Section of Human and Translational Immunology