2024
Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms
Xia J, Kutas M, Salmon D, Stoermann A, Rigatuso S, Farias S, Edland S, Brewer J, Olichney J. Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms. Cerebral Cortex 2024, 34: bhae398. PMID: 39390709, DOI: 10.1093/cercor/bhae398.Peer-Reviewed Original ResearchConceptsEvent-related brain potentialsAmnestic mild cognitive impairmentHippocampal occupancyBrain potentialsMemory abilityNegative ERP effectExecutive function abilitiesVisual memory abilityImpaired episodic memoryVerbal memory abilitiesAlzheimer's diseaseInvestigate neural mechanismsObject recognition taskVisual object recognitionVisual object recognition taskCognitively unimpaired participantsMild cognitive impairmentERP effectsNeuropsychological measuresExecutive functionEpisodic memoryHippocampal functionCompensatory mechanismsVisual memoryNeural mechanismsWhole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer's disease
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls T, Andersen S, Zmuda J, Thyagarajan B, Yashin A, Wojczynski M, Krinsky‐McHale S, Handen B, Christian B, Head E, Mapstone M, Schupf N, Lee J, Barral S, Study T, Abner E, Adams P, Aguirre A, Albert M, Albin R, Allen M, Alvarez L, Andrews H, Apostolova L, Arnold S, Asthana S, Atwood C, Ayres G, Barber R, Barnes L, Barral S, Bartlett J, Beach T, Becker J, Beecham G, Benchek P, Bennett D, Bertelson J, Biber S, Bird T, Blacker D, Boeve B, Bowen J, Boxer A, Brewer J, Burke J, Burns J, Bush W, Buxbaum J, Byrd G, Cantwell L, Cao C, Carlsson C, Carrasquillo M, Chan K, Chasse S, Chen Y, Chesselet M, Chin N, Chui H, Chung J, Craft S, Crane P, Cranney M, Cruchaga C, Cuccaro M, Culhane J, Cullum C, Darby E, Davis B, De Jager P, DeCarli C, DeToledo J, Dickson D, Dobbins N, Duara R, Ertekin‐Taner N, Evans D, Faber K, Fairchild T, Fallin D, Fallon K, Fardo D, Farlow M, Farrell J, Farrer L, Fernandez‐Hernandez V, Foroud T, Frosch M, Galasko D, Gamboa A, Gauthreaux K, Gefen T, Geschwind D, Ghetti B, Gilbert J, Goate A, Grabowski T, Graff‐Radford N, Griswold A, Haines J, Hakonarson H, Hall K, Hall J, Hamilton R, Hamilton‐Nelson K, Han X, Harari O, Hardy J, Harrell L, Head E, Henderson V, Hernandez M, Honig L, Huebinger R, Huentelman M, Hulette C, Hyman B, Hynan L, Ibanez L, Jarvik G, Jayadev S, Jin L, Johnson K, Johnson L, Jones B, Jun G, Kamboh M, Kang M, Karydas A, Katz M, Kauwe J, Kaye J, Keene C, Keller B, Khaleeq A, Kim R, Knebl J, Kowall N, Kramer J, Kukull W, Kunkle B, Kuzma A, LaFerla F, Lah J, Larson E, Lerch M, Lerner A, Leung Y, Leverenz J, Levey A, Lieberman A, Lipton R, Lopez O, Lunetta K, Lyketsos C, Mains D, Manly J, Mark L, Marquez D, Marson D, Martin E, Masliah E, Massman P, Masurkar A, Mayeux R, McCormick W, McCurry S, McDonough S, McKee A, Mesulam M, Mez J, Miller B, Miller C, Mock C, Moghekar A, Montine T, Monuki E, Mooney S, Morris J, Mukherjee S, Myers A, Naj A, Nguyen T, Noble J, Nudelman K, O'Bryant S, Ormsby K, Ory M, Palmer R, Parisi J, Paulson H, Pavlik V, Paydarfar D, Perez V, Pericak‐Vance M, Petersen R, Polk M, Qu L, Quiceno M, Quinn J, Raj A, Rajabli F, Ramanan V, Reiman E, Reisch J, Reitz C, Ringman J, Roberson E, Rodriguear M, Rogaeva E, Rosen H, Rosenberg R, Royall D, Sano M, Saykin A, Schellenberg G, Schneider J, Schneider L, Seeley W, Sherva R, Shibata D, Small S, Smith A, Smith J, Song Y, Spina S, St George‐Hyslop P, Stern R, Stevens A, Strittmatter S, Sultzer D, Swerdlow R, Teich A, Tilson J, Tosto G, Trojanowski J, Troncoso J, Tsuang D, Valladares O, Van Deerlin V, Van Dyck C, Van Eldik L, Vance J, Vardarajan B, Vassar R, Vinters H, Wang L, Weintraub S, Welsh‐Bohmer K, Wheeler N, Wijsman E, Wilhelmsen K, Williams B, Williamson J, Wilms H, Wingo T, Wisniewski T, Woltjer R, Woon M, Younkin S, Yu L, Zhao Y, Zhou X, Zhu C, Aizenstein H, Ances B, Andrews H, Bell K, Birn R, Brickman A, Bulova P, Cheema A, Chen K, Christian B, Clare I, Cohen A, Constantino J, Doran E, Fagan A, Feingold E, Foroud T, Handen B, Harp J, Hartley S, Head E, Henson R, Hom C, Honig L, Ikonomovic M, Johnson S, Jordan C, Kamboh M, Keator D, Klunk W, Kofler J, Krinsky‐McHale S, Lai F, Lao P, Laymon C, Lee J, Lott I, Lupson V, Mapstone M, Mathis C, Minhas D, Nadkarni N, O'Bryant S, Parisi M, Pang D, Petersen M, Price J, Pulsifer M, Rafii M, Reiman E, Rizvi B, Rosas H, Ryan L, Schmitt F, Schupf N, Silverman W, Tudorascu D, Tumuluru R, Varadarajan B, White D, Yassa M, Zaman S, Zhang F. Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer's disease. Alzheimer's & Dementia 2024, 20: 2670-2679. PMID: 38380866, PMCID: PMC11032545, DOI: 10.1002/alz.13718.Peer-Reviewed Original ResearchConceptsLate-onset Alzheimer's diseaseGenes associated with late-onset Alzheimer's diseaseLate-onset Alzheimer's disease riskSeveral single nucleotide polymorphismsVariants associated with late-onset Alzheimer diseaseBeta-amyloidIdentified several single nucleotide polymorphismsWhole-genome sequence analysisGenome sequence analysisLevels of beta-amyloidAlzheimer's diseaseTight linkage disequilibriumMicrotubule associated proteinSingle nucleotide polymorphismsFamily studiesCandidate lociMTUS2Linkage disequilibriumSequence analysisAssociation analysisNucleotide polymorphismsGenetic associationAlzheimer's dementiaAssociated proteinGenetic component
2023
LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry.
Katsumata Y, Fardo D, Shade L, Bowen J, Crane P, Jarvik G, Keene C, Larson E, McCormick W, McCurry S, Mukherjee S, Kowall N, McKee A, Honig R, Lawrence S, Vonsattel J, Williamson J, Small S, Burke J, Hulette C, Welsh-Bohmer K, Gearing M, Lah J, Levey A, Wingo T, Apostolova L, Farlow M, Ghetti B, Saykin A, Spina S, Albert M, Lyketsos C, Troncoso J, Frosch M, Green R, Growdon J, Hyman B, Tanzi R, Potter H, Dickson D, Ertekin-Taner N, Graff-Radford N, Parisi J, Petersen R, Duara R, Buxbaum J, Goate A, Sano M, Masurkar A, Wisniewski T, Bigio E, Mesulam M, Weintraub S, Vassar R, Kaye J, Quinn J, Woltjer R, Barnes L, Bennett D, Schneider J, Yu L, Henderson V, Fallon K, Harrell L, Marson D, Roberson E, DeCarli C, Jin L, Olichney J, Kim R, LaFerla F, Monuki E, Head E, Sultzer D, Geschwind D, Vinters H, Chesselet M, Galasko D, Brewer J, Boxer A, Karydas A, Kramer J, Miller B, Rosen H, Seeley W, Burns J, Swerdlow R, Abner E, Fardo D, Van Eldik L, Albin R, Lieberman A, Paulson H, Arnold S, Trojanowski J, Van Deerlin V, Hamilton R, Kamboh M, Lopez O, Becker J, Cao C, Raj A, Smith A, Chui H, Miller C, Ringman J, Schneider L, Bird T, Sonnen J, Yu C, Grabowski T, Peskind E, Raskind M, Li G, Tsuang D, Asthana S, Atwood C, Carlsson C, Sager M, Chin N, Craft S, Cairns N, Morris J, Cruchaga C, Strittmatter S, Reiman E, Beach T, Huentelman M, Hardy J, Myers A, Kauwe J, Hakonarson H, Blacker D, Montine T, Baldwin C, Farrer L, Jun G, Lunetta K, Bush W, Haines J, Lerner A, Zhou X, Barral S, Reitz C, Vardarajan B, Mayeux R, Beecham G, Carney R, Cuccaro M, Gilbert J, Hamilton-Nelson K, Kunkle B, Martin E, Pericak-Vance M, Vance J, Cantwell L, Kuzma A, Malamon J, Naj A, Qu L, Schellenberg G, Valladares O, Wang L, Zhao Y, Leverenz J, De Jager P, Evans D, Katz M, Lipton R, Boeve B, Allen M, Carrasquillo M, Younkin S, Kukull W, Faber K, Foroud T, Pavlik V, Massman P, Darby E, Rodriguear M, Khaleeq A, Royall D, Stevens A, Ory M, DeToledo J, Wilms H, Johnson K, Perez V, Hernandez M, Wilhelmsen K, Tilson J, Chasse S, Barber R, Fairchild T, O’Bryant S, Knebl J, Hall J, Johnson L, Mains D, Alvarez L, Gamboa A, Paydarfar D, Bertelson J, Woon M, Ayres G, Aguirre A, Palmer R, Polk M, Adams P, Huebinger R, Reisch J, Rosenberg R, Cullum M, Williams B, Quiceno M, Hynan L, Smith J, Davis B, Nguyen T, Rogaeva E, George-Hyslop P, Nelson P. LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry. Journal Of Neuropathology & Experimental Neurology 2023, 82: 760-768. PMID: 37528055, PMCID: PMC10440720, DOI: 10.1093/jnen/nlad059.Peer-Reviewed Original ResearchConceptsSingle nucleotide variantsLimbic-predominant age-related TDP-43 encephalopathyAfrican ancestryRisk allelesIndividuals of African ancestryRisk-associated allelesTDP-43 proteinopathyGenetic risk factorsNucleotide variantsAllele frequenciesGenetic determinantsGenomics ConsortiumPersons of African ancestryTDP-43AllelesAncestryNational Alzheimer's Coordinating CenterDisease pathologyGenetic factorsNeuropathological featuresGRNAfrican American subjectsHippocampal sclerosisABCC9HS pathology
2012
Predicting missing biomarker data in a longitudinal study of Alzheimer disease
Lo R, Jagust W, Aisen P, Jack C, Toga A, Beckett L, Gamst A, Soares H, C. Green R, Montine T, Thomas R, Donohue M, Walter S, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Chen K, Morris J, Lee V, Korecka M, Crawford K, Neu S, Harvey D, Kornak J, Saykin A, Foroud T, Potkin S, Shen L, Buckholtz N, Kaye J, Dolen S, Quinn J, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Tang C, Marzloff G, Toledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Pedroso J, Toroney J, Rusinek H, de Leon M, De Santi S, Doraiswamy P, Petrella J, Aiello M, Clark C, Pham C, Nunez J, Smith C, Given C, Hardy P, Lopez O, Oakley M, Simpson D, Ismail M, Brand C, Richard J, Mulnard R, Thai G, Mc-Adams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Laubinger M, Bartzokis G, Silverman D, Lu P, Graff-Radford MBBCH N, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, MacAvoy M, Benincasa A, Chertkow H, Bergman H, Hosein C, Black S, Graham S, Caldwell C, Hsiung G, Feldman H, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Wu C, Johnson N, Mesulam M, Sadowsky C, Martinez W, Villena T, Turner S, Johnson K, Behan K, Sperling R, Rentz D, Johnson K, Rosen A, Tinklenberg J, Ashford W, Sabbagh M, Connor D, Jacobson S, Killiany R, Norbash A, Nair A, Obisesan T, Jayam-Trouth A, Wang P, Lerner A, Hudson L, Ogrocki P, DeCarli C, Fletcher E, Carmichael O, Kittur S, Mirje S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Hendin B, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Gandy S, Marenberg M, Rovner B, Pearlson G, Anderson K, Saykin A, Santulli R, Englert J, Williamson J, Sink K, Watkins F, Ott B, Wu C, Cohen R, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J. Predicting missing biomarker data in a longitudinal study of Alzheimer disease. Neurology 2012, 78: 1376-1382. PMID: 22491869, PMCID: PMC3345787, DOI: 10.1212/wnl.0b013e318253d5b3.Peer-Reviewed Original ResearchAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersCognitive DysfunctionCohort StudiesDementia, VascularFluorodeoxyglucose F18HomocysteineHumansLogistic ModelsLongitudinal StudiesMagnetic Resonance ImagingNeuropsychological TestsPatient DropoutsPeptide FragmentsPositron-Emission TomographyResearch DesignRisk FactorsTau Proteins