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Associate Research Scientist
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Research at a Glance
Yale Co-Authors
Frequent collaborators of James Brewer's published research.
Publications Timeline
A big-picture view of James Brewer's research output by year.
Howard Feldman, MD, FRCPC, FAAN (Neurology)
Christopher van Dyck, MD
Stephen Strittmatter, MD, PhD, AB
Godfrey Pearlson, MA, MBBS
Adam Mecca, MD, PhD
Carmen I. Carrión, PsyD, ABPP
23Publications
311Citations
Publications
2026
Relationships between fine memory discrimination and tau burden in two independent cohorts of older adults
Fenton L, Aslanyan V, Jacobs D, Salmon D, Brewer J, Rissman R, Shadyab A, Harrison T, Evans A, LaCroix A, Feldman H, Baker L, Pa J. Relationships between fine memory discrimination and tau burden in two independent cohorts of older adults. Neuropsychologia 2026, 224: 109393. PMID: 41672403, DOI: 10.1016/j.neuropsychologia.2026.109393.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMnemonic Similarity TaskMemory discriminationHippocampal volumeLogical memoryLower hippocampal volumeHigher tauOlder adultsMnemonic similarity task performanceAssociated with higher tauMedial temporal lobeTraditional memory testsHippocampal integrityMemory testBrain measuresDiscrimination taskAD prevention trialsTemporal lobeAmnestic MCICognitive AssessmentSimilarity taskHippocampalCohort of older adultsAmyloid burdenAmyloid PETMemory
2025
The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias
George G, Keller S, Abner E, Adar S, Alosco M, Apostolova L, Bakulski K, Barnes L, Bateman J, Batterman S, Beach T, Bendlin B, Bennett D, Betthauser T, Brewer J, Buckingham W, Carrión C, Chodosh J, Craft S, Croff R, Fabio A, Farias S, Feldman E, Goldstein F, Goutman S, Green‐Harris G, Henderson V, Karikari T, Kofler J, Kucharska‐Newton A, Lamar M, Lanata S, Lepping R, Lingler J, Lockhart S, Mahnken J, Marsh K, Mathew J, Mecca A, Meyer O, Miller B, Morris J, Neugroschl J, O'Connor M, Paulson H, Perrin R, Pettigrew C, Pierce A, Powell W, Pyarajan S, Raji C, Reiman E, Risacher S, Rissman R, Espinosa P, Sano M, Saykin A, Serrano G, Singh V, Soldan A, Sultzer D, van Dyck C, Whitmer R, Wisniewski T, Woltjer R, Yu M, Zhu C, Kind A. The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70810. PMID: 41230793, PMCID: PMC12613078, DOI: 10.1002/alz.70810.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAlzheimer's Disease Research CenterSocial exposomeArea Deprivation IndexNeighborhood studiesBrain healthNational Alzheimer's Coordinating CenterAdverse social exposuresDementia riskDeprivation indexADRDHealth measuresExposome factorsAlzheimer's diseaseDementiaStudy findingsExposomeSocial exposureCoordinating CenterCognitive functionHealthData collectionPreliminary findingsResearch CenterAlzheimerRiskUnveiling Early Signs of Preclinical Alzheimer’s Disease Through ERP Analysis with Weighted Visibility Graphs and Ensemble Learning
Liu Y, Xia J, Kan Z, Zhang J, Toprani S, Brewer J, Kutas M, Liu X, Olichney J. Unveiling Early Signs of Preclinical Alzheimer’s Disease Through ERP Analysis with Weighted Visibility Graphs and Ensemble Learning. Bioengineering 2025, 12: 814. PMID: 40868327, PMCID: PMC12383961, DOI: 10.3390/bioengineering12080814.Peer-Reviewed Original ResearchConceptsWeighted visibility graphEnsemble learningVisibility graphEEG signalsNon-linear classifiersMachine learning algorithmsAmount of dataMachine learning methodsLearning algorithmsInput featuresClassification accuracyEnsemble methodsEffective classificationLearning methodsPrincipal component analysisDetection of Alzheimer's diseaseEEG channelsWeighted edgesInput dataData pointsClassifierEarly detection of Alzheimer's diseaseGraphRepetitive tasksNatural visibility graphMulti-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee W, Haut J, Hamilton-Nelson K, Wheeler N, Zhao Y, Farrell J, Grunin M, Leung Y, Kuksa P, Li D, da Fonseca E, Mez J, Palmer E, Pillai J, Sherva R, Song Y, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma A, Abner E, Adams L, Adams P, Aguirre A, Albert M, Albin R, Allen M, Alvarez L, Apostolova L, Arnold S, Asthana S, Atwood C, Auerbach S, Ayres G, Baldwin C, Barber R, Barnes L, Barral S, Beach T, Becker J, Beecham G, Beekly D, Benitez B, Bennett D, Bertelson J, Bird T, Blacker D, Boeve B, Bowen J, Boxer A, Brewer J, Burke J, Burns J, Buxbaum J, Cairns N, Cantwell L, Cao C, Carlson C, Carlsson C, Carney R, Carrasquillo M, Chasse S, Chesselet M, Chin N, Chui H, Chung J, Craft S, Crane P, Cribbs D, Crocco E, Cruchaga C, Cuccaro M, Cullum M, Darby E, Davis B, De Jager P, DeCarli C, DeToledo J, Dick M, Dickson D, Dombroski B, Doody R, Duara R, Ertekin-Taner N, Evans D, Faber K, Fairchild T, Fallon K, Fardo D, Farlow M, Fernandez-Hernandez V, Ferris S, Friedland R, Foroud T, Frosch M, Fulton-Howard B, Galasko D, Gamboa A, Gearing M, Geschwind D, Ghetti B, Gilbert J, Go R, Goate A, Grabowski T, Graff-Radford N, Green R, Growdon J, Hakonarson H, Hall J, Hamilton R, Harari O, Hardy J, Harrell L, Head E, Henderson V, Hernandez M, Hohman T, Honig L, Huebinger R, Huentelman M, Hulette C, Hyman B, Hynan L, Ibanez L, Jarvik G, Jayadev S, Jin L, Johnson K, Johnson L, Kamboh M, Karydas A, Katz M, Kauwe J, Kaye J, Keene C, Khaleeq A, Kikuchi M, Kim R, Knebl J, Kowall N, Kramer J, Kukull W, LaFerla F, Lah J, Larson E, Lerner A, Leverenz J, Levey A, Lieberman A, Lipton R, Logue M, Lopez O, Lunetta K, Lyketsos C, Mains D, Margaret F, Marson D, Martin E, Martiniuk F, Mash D, Masliah E, Massman P, Masurkar A, McCormick W, McCurry S, McDavid A, McDonough S, McKee A, Mesulam M, Miller B, Miller C, Miller J, Montine T, Monuki E, Morris J, Mukherjee S, Myers A, Nguyen T, Obisesan T, O’Bryant S, Olichney J, Ory M, Palmer R, Parisi J, Paulson H, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen R, Petrovitch H, Pierce A, Polk M, Poon W, Potter H, Qu L, Quiceno M, Quinn J, Raj A, Raskind M, Reiman E, Reisberg B, Reisch J, Ringman J, Roberson E, Rodriguear M, Rogaeva E, Rosen H, Rosenberg R, Royall D, Sabbagh M, Sadovnick A, Sager M, Sano M, Saykin A, Schneider J, Schneider L, Seeley W, Slifer S, Small S, Smith A, Smith J, Sonnen J, Spina S, George-Hyslop P, Starks T, Stern R, Stevens A, Strittmatter S, Sultzer D, Swerdlow R, Tanzi R, Tilson J, Trojanowski J, Troncoso J, Tsolaki M, Tsuang D, Van Deerlin V, van Eldik L, Vance J, Vardarajan B, Vassar R, Vinters H, Vonsattel J, Weintraub S, Welsh-Bohmer K, Whitehead P, Wijsman E, Wilhelmsen K, Williams B, Williamson J, Wilms H, Wingo T, Wisniewski T, Woltjer R, Woon M, Wright C, Wu C, Younkin S, Yu C, Yu L, Zhu X, Kunkle B, Bush W, Miyashita A, Byrd G, Wang L, Farrer L, Haines J, Mayeux R, Pericak-Vance M, Schellenberg G, Jun G, Reitz C, Naj A. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease. Genome Biology 2025, 26: 210. PMID: 40676597, PMCID: PMC12273372, DOI: 10.1186/s13059-025-03564-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLate-onset Alzheimer's diseaseGenome-wide association studiesAlzheimer's Disease Genetics ConsortiumNon-Hispanic whitesAlzheimer's diseaseGenome-Wide Meta-AnalysisPopulation-specific lociGenome-wide significanceNeuronal developmentMeta-analysisReceptor activity regulationGWAS meta-analysesEast Asian individualsGWAS datasetFixed-effect meta-analysisGenetic architectureRisk lociCross-ancestryAssociation studiesRandom-effects meta-analysisSusceptibility lociDiverse ancestryGWAS studiesGenetics ConsortiumRisk variantsTranscriptome profiling of cerebrospinal fluid in Alzheimer's disease reveals molecular dysregulations associated with disease
De Sota R, Berghuis B, Khoury S, Zhuang J, Rissman R, Brewer J, Quake S, Sninsky J, Toden S. Transcriptome profiling of cerebrospinal fluid in Alzheimer's disease reveals molecular dysregulations associated with disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2025, 11: e70152. PMID: 40963533, PMCID: PMC12438960, DOI: 10.1002/trc2.70152.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell-free messenger RNACf-mRNAGene transcriptionTranscriptome profilingAlzheimer's diseaseMolecular characterizationMessenger RNAAssociated with ADTranscriptional profilesMolecular contentBiological processesDysregulated genesGenesTranscriptionHuman CSF samplesAD subjectsNeurodegenerative diseasesProfiling of cerebrospinal fluidTranscriptomeSynaptic signalingRNAPrevalence of neurodegenerative diseasesMolecular dysregulationAlzheimerHuman cerebrospinal fluidPrognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
Qiu Y, Jacobs D, Messer K, Salmon D, Wellington C, Stukas S, Revta C, Brewer J, Léger G, Askew B, Donahue L, Kaplita S, Coric V, Qureshi I, Feldman H. Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease. Alzheimer's Research & Therapy 2025, 17: 97. PMID: 40317057, PMCID: PMC12046789, DOI: 10.1186/s13195-025-01745-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMild to moderate ADADAS-cog11CDR-SBBaseline plasma NfLAlzheimer's diseasePlasma biomarkersMild-to-moderate Alzheimer's diseasePrognostic valueClinical trialsBaseline NfLPlasma NfLPlacebo-controlled trialCortical volumeConcentrations of plasma biomarkersMethodsPost hoc analysisDesign of clinical trialsClinical outcome dataIncreased ventricular volumeTrial participantsVolumetric MRIBaseline concentrationsEarly disease stagesClinical trial designTrial entry criteriaAD trialsEffects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
Baker L, Pa J, Katula J, Aslanyan V, Salmon D, Jacobs D, Chmelo E, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman R, Taylor C, Léger G, Messer K, Evans A, Okonkwo O, Shadyab A, Zou J, Jin S, Thomas R, Zhang J, La Croix A, Cotman C, Feldman H, Group F. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimer's & Dementia 2025, 21: e14586. PMID: 40271888, PMCID: PMC12019696, DOI: 10.1002/alz.14586.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSedentary older adultsAmnestic mild cognitive impairmentIntensity aerobic trainingMild cognitive impairmentEffects of exerciseRandomized Controlled TrialsIntervention deliveryAerobic trainingOlder adultsMonths of supervised exerciseCognitive impairmentMultisite Randomized Controlled TrialCognitive trajectoriesLower-intensity exerciseMeasure of global cognitive functionRandomized controlled trials of adultsTests of executive functionIntervention group differencesMeasures of brain healthAssess intervention efficacyGlobal cognitive functionGlobal cognitive compositeMild cognitive impairment groupSupervised exerciseMild memory problems
2024
Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy
Barisano G, Iv M, Choupan J, Hayden-Gephart M, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCarli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geld-macher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D’Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy. EBioMedicine 2024, 111: 105523. PMID: 39721217, PMCID: PMC11732520, DOI: 10.1016/j.ebiom.2024.105523.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRisk of dementiaDementia riskAccelerated brain atrophyLower risk of dementiaMeasures of cognitive functionLongitudinal studyUS National Institutes of HealthNational Institutes of HealthCombat dementiaInstitutes of HealthPerivascular spaces countAlzheimer's disease biomarkersUS National InstitutesClinical measures of cognitive functioningDementiaBrain healthMixed-effects modelsScreening toolClinical measuresConfounding factorsObservational studyCognitive declineLongitudinal trajectoriesParticipantsBrain atrophyX‐chromosome-wide association study for Alzheimer’s disease
Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi S, Bis J, Grenier-Boley B, Rodriguez O, Kleineidam L, Young J, Tripathi K, Wang L, Varma A, Campos-Martin R, van der Lee S, Damotte V, de Rojas I, Palmal S, Lipton R, Reiman E, McKee A, De Jager P, Bush W, Small S, Levey A, Saykin A, Foroud T, Albert M, Hyman B, Petersen R, Younkin S, Sano M, Wisniewski T, Vassar R, Schneider J, Henderson V, Roberson E, DeCarli C, LaFerla F, Brewer J, Swerdlow R, Van Eldik L, Hamilton-Nelson K, Paulson H, Naj A, Lopez O, Chui H, Crane P, Grabowski T, Kukull W, Asthana S, Craft S, Strittmatter S, Cruchaga C, Leverenz J, Goate A, Kamboh M, George-Hyslop P, Valladares O, Kuzma A, Cantwell L, Riemenschneider M, Morris J, Slifer S, Dalmasso C, Castillo A, Küçükali F, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Düzel E, Grimmer T, Wiltfang J, Heilmann-Heimbach S, Moebus S, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido M, Pastor P, Sánchez-Valle R, Álvarez V, Boada M, García-González P, Puerta R, Mir P, Real L, Piñol-Ripoll G, García-Alberca J, Royo J, Rodriguez-Rodriguez E, Soininen H, de Mendonça A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Thomassen J, Pijnenburg Y, Holstege H, van Swieten J, Ramakers I, Verhey F, Scheltens P, Graff C, Papenberg G, Giedraitis V, Boland A, Deleuze J, Nicolas G, Dufouil C, Pasquier F, Hanon O, Debette S, Grünblatt E, Popp J, Ghidoni R, Galimberti D, Arosio B, Mecocci P, Solfrizzi V, Parnetti L, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Spallazzi M, Seripa D, Rainero I, Daniele A, Bossù P, Masullo C, Rossi G, Jessen F, Fernandez V, Kehoe P, Frikke-Schmidt R, Tsolaki M, Sánchez-Juan P, Sleegers K, Ingelsson M, Haines J, Farrer L, Mayeux R, Wang L, Sims R, DeStefano A, Schellenberg G, Seshadri S, Amouyel P, Williams J, van der Flier W, Ramirez A, Pericak-Vance M, Andreassen O, Van Duijn C, Hiltunen M, Ruiz A, Dupuis J, Martin E, Lambert J, Kunkle B, Bellenguez C. X‐chromosome-wide association study for Alzheimer’s disease. Molecular Psychiatry 2024, 30: 2335-2346. PMID: 39633006, PMCID: PMC12092188, DOI: 10.1038/s41380-024-02838-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsX-chromosome inactivationX chromosomeAssociation studiesAlzheimer's diseaseGenome-wide significant signalsX chromosome-wide association studyGenome-wide association studiesAD casesEscape X chromosome inactivationNon-pseudoautosomal regionRandom X-chromosome inactivationSignificant lociGenetic risk factorsGenetic landscapeLociIndex variantsSignificant signalsAlzheimerRisk factorsXq25FRMPD4Dach2PJA1XWASSignalWMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study
DeCarli C, Rajan K, Jin L, Hinman J, Johnson D, Harvey D, Fornage M, Beiser A, Gonzalez H, Kukull W, Barnes L, Elahi F, Rajan K, Croff R, Kramer J, Weickenmeier J, Tudorascu D, Albert M, Craft S, Jicha G, Wolk D, Paulson H, Brewer J, Asthana S, Seshadri S, Brickman A, Chui H, Nelson A, Savitz S, Saykin A, Geldmacher D, Masurkar A, Rundek T, Maillard P, Knaack A. WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study. Stroke 2024, 56: 758-776. PMID: 39545328, PMCID: PMC11850211, DOI: 10.1161/strokeaha.124.045903.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDisproportionate burdenRisk factorsCognitive complaintsMeasures of genetic riskMagnetic resonance imaging measuresNon-Hispanic White backgroundsStroke-free populationCognitive impairmentEthnic minority populationsWhite matter hyperintensitiesAt-risk individualsIndividuals of diverse backgroundsRelevant assessment toolsVascular risk factorsDementia riskDementia increaseDiverse backgroundsGenetic riskMinority populationsBrain healthRisk scoreAssessment toolNo studyClinical assessmentCerebrovascular injury
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