2019
The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon
Grau KR, Zhu S, Peterson ST, Helm EW, Philip D, Phillips M, Hernandez A, Turula H, Frasse P, Graziano VR, Wilen CB, Wobus CE, Baldridge MT, Karst SM. The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. Nature Microbiology 2019, 5: 84-92. PMID: 31768030, PMCID: PMC6925324, DOI: 10.1038/s41564-019-0602-7.Peer-Reviewed Original ResearchConceptsNorovirus infectionType III interferonsMurine norovirus infectionCommensal bacteriaIII interferonsIntestinal microbiotaType III interferon responseBile acid receptorProximal small intestineRegional expression profilesProximal gutAntibiotic treatmentViral infectionSmall intestineIntestinal tractAcid receptorsInfectionInterferon responseMicrobiotaInterferonPathogenic enteric virusesEnteric virusesHost metabolitesGutExpression profiles
2016
Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome
Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe 2016, 19: 311-322. PMID: 26962942, PMCID: PMC4821831, DOI: 10.1016/j.chom.2016.02.011.Peer-Reviewed Original ResearchConceptsAnti-retroviral therapyEnteric viromePeripheral CD4 T-cell countLower CD4 T countsCD4 T-cell countHuman immunodeficiency virus (HIV) infectionProgressive HIV infectionT-cell countsImmunodeficiency virus infectionAcquired Immunodeficiency SyndromeHIV-uninfectedUgandan patientsHIV infectionImmunodeficiency syndromeIntestinal translocationDisease progressionVirus infectionART treatmentBacterial microbiomeCell countInfectionGut bacterial communitiesPatientsImmunodeficiencySpecific bacteria