2011
Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
Jiang C, Parrish N, Wilen C, Li H, Chen Y, Pavlicek J, Berg A, Lu X, Song H, Tilton J, Pfaff J, Henning E, Decker J, Moody M, Drinker M, Schutte R, Freel S, Tomaras G, Nedellec R, Mosier D, Haynes B, Shaw G, Hahn B, Doms R, Gao F. Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism. Journal Of Virology 2011, 85: 10669-10681. PMID: 21835785, PMCID: PMC3187499, DOI: 10.1128/jvi.05249-11.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SubstitutionApelin ReceptorsCD4-Positive T-LymphocytesCells, CulturedEnv Gene Products, Human Immunodeficiency VirusGene ExpressionHIV-1HumansMacrophagesReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, HIVReceptors, LipoxinReceptors, PeptideViral TropismConceptsF virusesHuman immunodeficiency virus type 1Immunodeficiency virus type 1Alternative coreceptor GPR15Sequential plasma samplesHuman immunodeficiency virusClade B virusesVirus type 1Cell linesPrimary human CD4Third variable loopEarly time pointsCoreceptor tropismFounder virusesMultiple CD4Immunodeficiency virusAlternative coreceptorsCCR5 coreceptorPrimary infectionB virusCXCR4 coreceptorFPRL-1T cellsHuman CD4Homozygous donors
2010
HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4+ T Cells
Pfaff JM, Wilen CB, Harrison JE, Demarest JF, Lee B, Doms RW, Tilton JC. HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4+ T Cells. Journal Of Virology 2010, 84: 6505-6514. PMID: 20410277, PMCID: PMC2903254, DOI: 10.1128/jvi.00374-10.Peer-Reviewed Original ResearchConceptsT cellsResistant virusesAntagonist aplavirocCCR5 antagonistsTropism shiftSmall-molecule CCR5 antagonistsEffector memory cellsT cell subsetsHIV-1 resistanceT cell homeostasisVirologic failureCell subsetsV3 loopPrimary CD4Virus infectionRelative sparingHost determinantsImmune functionCCR5Heterologous virusesViral resistanceViral tropismCentral memoryDrug resistanceAltered tropism