Christine Bakhoum, MD, MAS
Assistant ProfessorCards
About
Research
Publications
2025
From Rare to Recognized
Bakhoum C. From Rare to Recognized. Kidney360 2025, 6: 1058-1059. PMCID: PMC12338346, DOI: 10.34067/kid.0000000803.Peer-Reviewed Original ResearchThe Retinal Fundus Verdict on Intensive Blood-Pressure Therapy Lower Is Better
Bakhoum M, Wong M, Jayaraj C, Goldbaum M, Bakhoum C. The Retinal Fundus Verdict on Intensive Blood-Pressure Therapy Lower Is Better. Journal Of The American College Of Cardiology 2025, 86: 1389-1391. PMID: 41105074, DOI: 10.1016/j.jacc.2025.06.009.Peer-Reviewed Original ResearchA Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing
Dibbs M, Matesva M, Theotoka D, Jayaraj C, Metiku B, Demkowicz P, Heng J, Wang Y, Bakhoum C, Chow J, Bakhoum M. A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing. Translational Vision Science & Technology 2025, 14: 19. PMID: 40244576, PMCID: PMC12013674, DOI: 10.1167/tvst.14.4.19.Peer-Reviewed Original ResearchConceptsCorneal ulcersTear samplesPolymerase chain reactionNanopore sequencingCorneal scrapingsBacterial pathogensTargeted antimicrobial therapyDetection of causative organismsIdentification of bacterial pathogensPolymerase chain reaction amplification of 16S rRNAAmplification of 16S rRNABacterial growthBacterial species identificationContralateral eyeAntimicrobial therapyImprove patient outcomesNext-generation sequencingCausative bacteriaCornealSchirmer stripsCausative organismDetect bacterial pathogensPolymerase chain reaction amplificationTraditional culture methodsCommensal bacteriaAssociations between Blood DNA Methylation and Histopathologic Features in Lupus Nephritis
Demkowicz P, Kavaliauskaite I, Faulkner S, Kent C, Shaw M, Kumar D, Ix J, Wilson F, Moledina D, Bakhoum M, Bakhoum C. Associations between Blood DNA Methylation and Histopathologic Features in Lupus Nephritis. Kidney360 2025, 6: 1404-1408. PMID: 40048255, PMCID: PMC12407129, DOI: 10.34067/kid.0000000758.Peer-Reviewed Original Research
2024
Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation
Bakhoum C, Au A, Bousquet E, Matesva M, Singer M, Jayaraj C, Romero‐Morales V, Somisetty S, Santina A, Bajar B, DeMaria A, Goldbaum M, Meadows J, Spatz E, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2024, 13: e035079. PMID: 39190603, PMCID: PMC11646541, DOI: 10.1161/jaha.123.035079.Peer-Reviewed Original ResearchThe Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods
South A, Giammattei V, Bagley K, Bakhoum C, Beasley W, Bily M, Biswas S, Bridges A, Byfield R, Campbell J, Chanchlani R, Chen A, McGowan L, Downs S, Fergeson G, Greenberg J, Hill-Horowitz T, Jensen E, Kallash M, Kamel M, Kiessling S, Kline D, Laisure J, Liu G, Londeree J, Lucas C, Mannemuddhu S, Mao K, Misurac J, Murphy M, Nugent J, Onugha E, Pudupakkam A, Redmond K, Riar S, Sethna C, Siddiqui S, Thumann A, Uss S, Vincent C, Viviano I, Walsh M, White B, Woroniecki R, Wu M, Yamaguchi I, Yun E, Weaver D. The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods. American Journal Of Epidemiology 2024, 193: 1650-1661. PMID: 38881045, PMCID: PMC11637526, DOI: 10.1093/aje/kwae116.Peer-Reviewed Original ResearchManual record reviewHypertensive disordersRecord reviewElectronic health record dataICD-10Health record dataInternational Classification of Diseases diagnostic codesReduce CVD burdenPrevalence of hypertensionIncreased prevalence of hypertensionCardiovascular mortality ratesCVD burdenBlood pressureInternational ClassificationDiagnostic codesClinical careRecord dataInclusion criteriaLife courseIncreased prevalencePediatric hypertensionLong-term consequencesMortality rateEpidemiologyBiomedical informatics
2023
Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation
Bakhoum C, Faulkner S, Ix J, Moledina D, Bakhoum M. Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation. Journal Of The American Society Of Nephrology 2023, 34: 243-243. DOI: 10.1681/asn.20233411s1243b.Peer-Reviewed Original ResearchRetinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation
Bakhoum C, Madala S, Lando L, Yarmohammadi A, Long C, Miguez S, Chan A, Singer M, Jin A, Steren B, Adabifirouzjaei F, Goldbaum M, DeMaria A, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2023, 12: e028853. PMID: 37577936, PMCID: PMC10492933, DOI: 10.1161/jaha.122.028853.Peer-Reviewed Original ResearchConceptsOptical coherence tomography scansAtrial fibrillationPerivascular lesionsTomography scanSpectral domain optical coherence tomography scansMacular spectral-domain optical coherence tomographySpectral-domain optical coherence tomographyMultivariable logistic regression modelCardiovascular risk factorsDomain optical coherence tomographyAtrial fibrillation groupCoronary artery diseaseIschemic heart diseaseSex-matched individualsCase-control studyPercentage of subjectsIschemic cardiovascular diseaseOptical coherence tomographyLogistic regression modelsCardiovascular workupCardiac emboliFibrillation groupSmoking historyArtery diseaseCarotid stenosisThe Role of Water in Uromodulin Regulation
Bakhoum C, Garimella P. The Role of Water in Uromodulin Regulation. Clinical Journal Of The American Society Of Nephrology 2023, 18: 985-987. PMID: 37418253, PMCID: PMC10564335, DOI: 10.2215/cjn.0000000000000233.Peer-Reviewed Original ResearchHypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox model
Academic Achievements & Community Involvement
Clinical Care
Overview
Christine Bakhoum, MD, is a pediatric nephrologist who says she was drawn to specializing in kidney disease because of its complexity.
“Nephrology is a lot of complex physiology and continuity of care with patients. I love being able to see a child with kidney disease through dialysis to transplant and watching them grow and flourish,” she says. “I enjoy walking parents through things step by step, as a lot of what I do is chronic disease and it can be overwhelming.”
Chronic kidney disease in children is progressive, and children are at high risk for cardiovascular diseases, Dr. Bakhoum says. “They will eventually need dialysis and a transplant, and to lessen their risk for cardiovascular disease and other problems, we try to modify the progression of the disease,” she says. “Because blood pressure causes more rapid progression, we make sure our children can accurately measure and control it. We want to optimize how that is done at home and in the clinic.”
When she’s talking with families. Dr. Bakhoum says she makes a point to explain things as best as she can and to lay out various options. “A lot of these situations are challenging and I like to show families what the journey ahead looks like, letting them know that our entire team, from doctors to social workers to nurses to dietitians will be with them the whole way,” she says.
“I love the moment when things get better for a child, when we’ve all been working together on the big picture and things click suddenly and things are going well.”
Dr. Bakhoum’s research focuses on optimizing blood pressure measurement and management in children with kidney disease.
Clinical Specialties
Yale Medicine News
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News
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
- May 02, 2024
56 Yale Pediatricians Recognized by Connecticut Magazine's 2024 “Top Doctors” List
- April 06, 2023
See Yale Pediatrics at PAS 2023
- January 10, 2023
SPR Announces Five New Members From Yale Pediatrics
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Events
Organization Only Gauthami Soma, MD, MHSIn-person Trask 3108 or zoom option See details below
Organization Only Laura Marie Nally, MDIn-person Trask 3108 or zoom option See details below
Organization Only Nadir Ijaz, MD, MHS, FAAPThe fourth Tuesdays of the month will be reserved for research intensive presentations and will take place in person only in Trask Conference Room, LMP 3108.
Organization Only Christine Bakhoum, MD, MAS