Carla Rothlin, PhD
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Cards
Appointments
Immunobiology
Primary
Pharmacology
Secondary
Titles
Co-Leader, Cancer Immunology, Yale Cancer Center
Contact Info
Appointments
Immunobiology
Primary
Pharmacology
Secondary
Titles
Co-Leader, Cancer Immunology, Yale Cancer Center
Contact Info
Appointments
Immunobiology
Primary
Pharmacology
Secondary
Titles
Co-Leader, Cancer Immunology, Yale Cancer Center
Contact Info
About
Titles
Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology
Co-Leader, Cancer Immunology, Yale Cancer CenterAppointments
Immunobiology
ProfessorPrimaryPharmacology
ProfessorSecondary
Other Departments & Organizations
- Cancer Immunology
- Immunobiology
- Immunology
- Interdepartmental Neuroscience Program
- K12 Calabresi Immuno-Oncology Training Program (IOTP)
- Microbiology
- Neuroscience Track
- Pharmacology
- Program for Neuroinflammation
- Rheumatic Diseases Research Core
- Rothlin Ghosh Lab
- Status of Women in Medicine Committee (SWIM)
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Fibrosis Program
- Yale Stem Cell Center
- Yale Ventures
- YCC Diversity, Equity, and Inclusion
Education & Training
- PhD
- University of Buenos Aires (2002)
Research
Overview
Immunobiology; Immune Homeostasis; TAM Receptor Tyrosine Kinases
Medical Subject Headings (MeSH)
Inflammation
ORCID
0000-0002-5693-5572
Research at a Glance
Yale Co-Authors
Frequent collaborators of Carla Rothlin's published research.
Publications Timeline
A big-picture view of Carla Rothlin's research output by year.
Research Interests
Research topics Carla Rothlin is interested in exploring.
Sourav Ghosh, PhD
Joseph Craft, MD
Eyiyemisi Damisah, MD
Jaime Grutzendler, MD
18Publications
2,097Citations
Inflammation
Publications
2024
In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK
Ghosh S, Finnemann S, Vollrath D, Rothlin C. In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK. International Journal Of Molecular Sciences 2024, 25: 5299. PMID: 38791338, PMCID: PMC11121519, DOI: 10.3390/ijms25105299.Peer-Reviewed Original ResearchConceptsReceptor tyrosine kinasesFamily of receptor tyrosine kinasesTAM family of receptor tyrosine kinasesEarly-onset photoreceptor degenerationKnockout mouse modelMolecular functionsNegative regulator of inflammationKnockout phenotypesNegative regulatorMouse geneticsRegulation of inflammationMolecular approachesEmbryonic stem cellsAnti-inflammatory functionsRetinal degenerationTyrosine kinasePhotoreceptor degenerationKnockout miceKnockout modelsMouse modelRodent modelsTAM familyMerTK functionStem cellsAllelesApoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, Wong M, Kylies D, Gräfe S, Edenhofer I, Aranda-Pardos I, Kriwet M, Haas H, Krause J, Hadjilaou A, Schromm A, Richardt U, Eggert P, Tappe D, Weidemann S, Ghosh S, Krebs C, A-Gonzalez N, Worthmann A, Lohse A, Huber S, Rothlin C, Puelles V, Jacobs T, Gagliani N, Bosurgi L. Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. Science 2024, 384: eabo7027. PMID: 38574142, DOI: 10.1126/science.abo7027.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApoptotic neutrophilsApoptotic cellsIL-4-induced gene expressionUptake of apoptotic neutrophilsApoptotic cell clearanceCell lineage identityResponse to IL-4Cell identityEfferocytic macrophagesPhagocytic receptorsGene expressionLineage identityCell clearanceApoptotic hepatocytesHeterogeneous cellsCellsMouse modelT cellsParasite-induced pathologyIL-4HepatocytesMacrophagesInterleukin-4EngulfmentPhenotypeTREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion?
Ghosh S, Rothlin C. TREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion? Neuro-Oncology 2024, 26: 840-842. PMID: 38290471, PMCID: PMC11066908, DOI: 10.1093/neuonc/noae019.Peer-Reviewed Original Research
2023
Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential
Hamley M, Leyk S, Casar C, Liebold I, Al Jawazneh A, Lanzloth C, Böttcher M, Haas H, Richardt U, Rothlin C, Jacobs T, Huber S, Adlung L, Pelczar P, Henao‐Mejia J, Bosurgi L. Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential. European Journal Of Immunology 2023, 54: e2350434. PMID: 37971166, DOI: 10.1002/eji.202350434.Peer-Reviewed Original ResearchAltmetricConceptsMucosal healingSchistosoma mansoni infectionCytokines IL-4Innovative therapeutic approachesDifferent intestinal diseasesWound-healing potentialIntestinal damageMucosal responsesMansoni infectionInflamed colonIL-4Intestinal disordersIntestinal diseaseNormal mucosaMurine modelTherapeutic approachesNovel regulatorType 2Advanced stageTherapy efficacyMacrophage responseCell therapyHealing potentialNew targetsIntestinal regeneration
2022
Regulation of bone homeostasis by MERTK and TYRO3
Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu T, Beitzen-Heineke A, Vargas-Delgado M, Pantel K, Bokemeyer C, Bhamidipati S, Darwish I, Masuda E, Burstyn-Cohen T, Alberto E, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Regulation of bone homeostasis by MERTK and TYRO3. Nature Communications 2022, 13: 7689. PMID: 36509738, PMCID: PMC9744875, DOI: 10.1038/s41467-022-33938-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCancer-induced bone lossBone homeostasisBone lossBone-resorbing osteoclastsBone metastasesProlong survivalOsteoanabolic therapyMultiple myelomaLung cancerBone-forming osteoblastsBone massHealthy micePreclinical modelsOsteoblast numberMerTKTyro3Bone formationMicePotent regulatorCell type-specific functionsFine equilibriumBlockadeCancerHomeostasisOsteoblast differentiationTissue-specific modifier alleles determine Mertk loss-of-function traits
Akalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Tissue-specific modifier alleles determine Mertk loss-of-function traits. ELife 2022, 11: e80530. PMID: 35969037, PMCID: PMC9433089, DOI: 10.7554/elife.80530.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-tumor immunityKO miceRetinal pigment epitheliumRetinal degenerationPigment epitheliumPro-inflammatory tumor microenvironmentSyngeneic mouse tumor modelsKO mice displayEarly-onset retinal degenerationSevere retinal degenerationMouse tumor modelsFailure of macrophagesKnockout mouse modelPhotoreceptor outer segmentsMouse modelMice displayTumor modelTumor microenvironmentMacrophage phagocytosisReceptor tyrosine kinasesMiceCritical roleDegenerationMerTKImmunity
2021
Decoding Cell Death: From a Veritable Library of Babel to Vade Mecum?
Hughes LD, Wang Y, Meli AP, Rothlin CV, Ghosh S. Decoding Cell Death: From a Veritable Library of Babel to Vade Mecum? Annual Review Of Immunology 2021, 39: 791-817. PMID: 33902311, DOI: 10.1146/annurev-immunol-102819-072601.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2020
Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
Damisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S, Grutzendler J. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo. Science Advances 2020, 6: eaba3239. PMID: 32637606, PMCID: PMC7319765, DOI: 10.1126/sciadv.aba3239.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCorpse removalPrecise spatiotemporal resolutionApoptotic cell removalReceptor tyrosine kinasesGlial cellsOrchestrated rolesTyrosine kinaseApoptotic bodiesCell deathSpecialized roleCoordinated interactionPhagocytic interactionSingle cellsBrain homeostasisCellsCell removalIntravital optical imagingSpatiotemporal resolutionRole of phagocytesSynchronized fashionKinaseMarked delayRoleHomeostasisAstrocytes
2019
Universal Principled Review: A Community-Driven Method to Improve Peer Review
Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel K, Chi H, O’Connell R, Wherry E, Pepper M, Consortium T, Brodsky I, Chang J, Arron J, Haining N, Bhattacharya D, Anderson M, Rothlin C, Schwab S, Belkaid Y, Molofsky A, Savage P, Mucida D, Iwasaki A, Victora G, Ansel K, Hamerman J, Masopust D, Barton G, Kaech S, Woodruff P, Stetson D, Scharschmidt T, Kedl R, Zúñiga E, Hoffmann A, Williams M, Mayer-Barber K, Shin S, Bensinger S, Lu L, Looney M, Round J, Amigorena S, Yewdell J, Sun J, Harty J. Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell 2019, 179: 1441-1445. PMID: 31835023, DOI: 10.1016/j.cell.2019.11.029.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science 2017, 356: 1072-1076. PMID: 28495875, PMCID: PMC5556699, DOI: 10.1126/science.aai8132.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApoptotic cellsTissue repair programChemotaxis genesTissue-resident macrophagesIL-4IL-13Tissue repairPattern recognition receptorsTissue repair genesCell adhesionRepair genesGenetic ablationCytokine-dependent inductionHelminth infectionsRecognition receptorsInduction of colitisGenesBroad repertoireSoluble cytokinesMacrophage functionCellsInductionHost responseEctopic activityInterleukin-4
Academic Achievements and Community Involvement
honor HHMI Faculty Scholar
National AwardHoward Hughes Medical InstituteDetails10/01/2016United Stateshonor Early Excellence Award
UnknownAmerican Asthma FoundationDetails07/01/2011United Stateshonor Novel Research Grant
UnknownLupus Research InstituteDetails02/01/2011United Stateshonor Senior Research Award
UnknownCrohn's and Colitis Foundation of AmericaDetails01/01/2010United Stateshonor Special Fellow (declined in favor of AHA award)
UnknownLeukemia and Lymphoma SocietyDetails05/02/2008United States
Links & Media
News
- January 01, 2024Source: Cytokine Society
ICIS Council Member Carla Rothlin Takes the Global ImmunoCourse to India
- February 28, 2021
MD-PhD Student Eric Song Receives Prestigious Harold M. Weintraub Graduate Student Award
- February 24, 2021
Releasing the Brakes on an Innate Immune System Response
- June 11, 2020
Global Immunospeaker Virtual Seminar Series Is Available Weekly
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The Anlyan Center
Academic Office
300 Cedar Street, Ste S625A
New Haven, CT 06519