Ryland Mortlock
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Biography
Ryland is a 4th year MD-PhD student pursuing his PhD in Genetics in the lab of Keith Choate, MD, PhD. His research focuses on applying animal models, spatial transcriptomics, and three-dimensional cell culture systems to study genetic skin diseases, specifically exploring how barrier dysfunction and cellular interactions contribute to inflammation in epidermal differentiation disorders. Prior to coming to Yale, Ryland graduated in 2019 from the University of Southern California with a degree in Chemical Engineering and completed a two-year Postbaccalaureate Research Fellowship at the National Institutes of Health.
Last Updated on September 07, 2024.
Education & Training
- Postbaccalaureate Research Fellowship
- National Heart Lung Blood Institute, National Institutes of Health (2021)
- BS
- University of Southern California, Viterbi School of Engineering, Chemical Engineering (Biochemical Emphasis) (2019)
Research
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Overview
Medical Research Interests
Biomedical Engineering; Data Science; Dermatology; Genetics; Genomics; Hematology; Nanotechnology; Systems Biology
ORCID
0000-0001-9666-4394
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ryland Mortlock's published research.
Publications Timeline
A big-picture view of Ryland Mortlock's research output by year.
Research Interests
Research topics Ryland Mortlock is interested in exploring.
Keith Choate, MD, PhD
Xingyuan Jiang, MD, MBBS
Jeffrey Cohen, MD, MPH
Jing Zhou
Former YSMJonathan Leventhal, MD
Alexandra Piotrowski-Daspit
Former YSM
26Publications
231Citations
Dermatology
Publications
Featured Publications
Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling
Mortlock RD, Georgia SK, Finley SD. Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling. Cellular And Molecular Bioengineering 2020, 14: 15-30. PMID: 33633812, PMCID: PMC7878662, DOI: 10.1007/s12195-020-00647-8.Peer-Reviewed Original ResearchCitationsAltmetricThe spectrum of cutaneous immune-related adverse events in patients with skin of color
Belzer A, Mortlock R, Olamiju B, Olino K, Cohen J, Leventhal J. The spectrum of cutaneous immune-related adverse events in patients with skin of color. Journal Of The American Academy Of Dermatology 2022, 88: 1156-1158. PMID: 36470309, PMCID: PMC10838520, DOI: 10.1016/j.jaad.2022.11.051.Peer-Reviewed Original ResearchCitationsAssessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology
Mortlock R, C. E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricInterrogation of clonal tracking data using barcodetrackR
Espinoza D, Mortlock R, Koelle S, Wu C, Dunbar C. Interrogation of clonal tracking data using barcodetrackR. Nature Computational Science 2021, 1: 280-289. PMID: 37621673, PMCID: PMC10449013, DOI: 10.1038/s43588-021-00057-4.Peer-Reviewed Original ResearchCitationsAltmetricAutosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma
Jiang X, Mortlock R, Lomakin I, Zhou J, Hu R, Cossio M, Bunick C, Choate K. Autosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma. British Journal Of Dermatology 2025, 192: 896-906. PMID: 39913669, PMCID: PMC12036768, DOI: 10.1093/bjd/ljaf049.Peer-Reviewed Original ResearchCitationsImpact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Lee B, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, DeRavin S, Shin T, Hong S, Dunbar C. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell 2024, 31: 788. PMID: 38599215, PMCID: PMC11114628, DOI: 10.1016/j.stem.2024.04.005.Commentaries, Editorials and LettersCitationsAltmetricTissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining
Mortlock RD, Wu C, Potter EL, Abraham DM, Allan DSJ, Hong SG, Roederer M, Dunbar CE. Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining. Frontiers In Immunology 2022, 12: 772332. PMID: 35095846, PMCID: PMC8790741, DOI: 10.3389/fimmu.2021.772332.Peer-Reviewed Original ResearchCitationsAltmetric
2026
De Novo Germline L858R EGFR Variants and Generalized Acanthosis Nigricans
Jiang X, Jeng M, Yang Z, Ugwu N, Cheng Y, Echeandia-Francis C, Mortlock R, Mani M, Rekhtman N, Podolanczuk A, Fiorino E, Plodkowski A, Lekwuttikarn R, Teng J, Walsh M, Yu H, Lin Z, Choate K. De Novo Germline L858R EGFR Variants and Generalized Acanthosis Nigricans. JAMA Dermatology 2026, 162: 236-244. PMID: 41533385, PMCID: PMC12805494, DOI: 10.1001/jamadermatol.2025.5414.Peer-Reviewed Original ResearchCitationsAltmetricPrenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (Macaca mulatta)
Piotrowski-Daspit A, Lynn A, Eaton D, Bracaglia L, Markey A, Mortlock R, Stitelman D, Martinez M, Lee C, Kliman H, Glazer P, Tarantal A, Saltzman W. Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (Macaca mulatta). Human Gene Therapy 2026, 37: 189-198. PMID: 41645533, PMCID: PMC12978997, DOI: 10.1177/10430342251414881.Peer-Reviewed Original ResearchCitations
2025
The underlying dermal scaffold affects molecular differentiation markers in 3-dimensional human epidermal equivalents
Zhao M, Mortlock R, Sutton L, Choate K. The underlying dermal scaffold affects molecular differentiation markers in 3-dimensional human epidermal equivalents. Journal Of Investigative Dermatology 2025, 146: 1384-1388.e3. PMID: 41344539, DOI: 10.1016/j.jid.2025.10.621.Peer-Reviewed Original Research
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activity Yale Journal of Biology and Medicine
2019 - PresentJournal ServiceEditorial Board Member
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