Josh Saskin
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Featured Publications
OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
Yang L, Renauer PA, Tang K, Saskin J, Zhou L, Zou C, Lee SH, Fox M, Johnson-Noya S, Weiss B, Deng S, Fang P, Chen B, Sferruzza G, Fooladi S, Zhao K, Park D, Zhang F, Tu J, Chen J, Moliterno J, Gunel M, Peng L, Chen S. OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours. Nature 2026 DOI: 10.1038/s41586-026-10149-8.Peer-Reviewed Original ResearchThis study investigates OR7A10-engineered CAR-NK cells, showing they enhance tumor-killing ability, persistence, and survival in solid tumor models, offering a scalable cancer therapy.
2025
Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption
. Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2403891122. PMID: 39951488, PMCID: PMC11874419, DOI: 10.1073/pnas.2403891122.Peer-Reviewed Original Research
2024
Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Feng Y, Xie N, Inoue F, Fan S, Saskin J, Zhang C, Zhang F, Hansen MEB, Nyambo T, Mpoloka SW, Mokone GG, Fokunang C, Belay G, Njamnshi AK, Marks MS, Oancea E, Ahituv N, Tishkoff SA. Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Nat Genet 2024, 56: 258-272. PMID: 38200130, DOI: 10.1038/s41588-023-01626-1.Peer-Reviewed Original ResearchIntegrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Feng Y, Xie N, Inoue F, Fan S, Saskin J, Zhang C, Zhang F, Hansen M, Nyambo T, Mpoloka S, Mokone G, Fokunang C, Belay G, Njamnshi A, Marks M, Oancea E, Ahituv N, Tishkoff S. Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Nature Genetics 2024, 56: 258-272. PMID: 38200130, PMCID: PMC11005318, DOI: 10.1038/s41588-023-01626-1.Peer-Reviewed Original ResearchConceptsSkin color diversitySignals of local adaptationMassively parallel reporter assaysColor diversityFunctional genomic analysisIntegrative functional genomic analysisSingle-nucleotide polymorphismsHi-CAdaptive evolutionGenomic analysisRegulatory elementsLocal adaptationPigment regulationGenetic variantsOxidative phosphorylationGenome editingMolecular mechanismsMelanin assayRegulatory activityLevels in vitroOCA2Skin pigmentationReporter assayTRPS1MITF
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